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Official Full Name Interleukin 6 signal transducer (gp130, oncostatin M receptor)
Background Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
Synonyms IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer (gp130, oncostatin M receptor)
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • GST
    • S
    • T7
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL6ST-1622H Recombinant Human IL6ST, Fc-His NSO Fc/His
    Human IL6ST-1682H Recombinant Human IL6ST Sf21 Insect Cell N/A
    Human IL6ST-26366TH Recombinant Human IL6ST Wheat Germ N/A
    Human IL6ST-265H Recombinant Human IL6ST Protein, Fc-tagged HEK293 Fc
    Human IL6ST-271H Recombinant Human IL6ST, ENLYFQ tagged Human Cell His
    Human IL6ST-5171H Recombinant Human IL6ST Protein, GST-tagged Wheat Germ GST
    Human IL6ST-787H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-788H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-935HCL Recombinant Human IL6ST cell lysate Human Cell N/A
    Mouse IL6ST-001MCL Recombinant Mouse IL6ST cell lysate CHO N/A
    Mouse Il6st-173M Recombinant Mouse Il6st protein, His-tagged HEK293 His
    Mouse Il6st-1743M Recombinant Mouse Interleukin 6 Signal Transducer, Fc-His NSO Fc
    Mouse Il6st-2208M Recombinant Mouse Il6st, Fc-His tagged CHO Fc/His
    Mouse Il6st-222M Recombinant Mouse Il6st protein, His/S-tagged E.coli His/S
    Mouse IL6ST-353M Recombinant Mouse IL6ST protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Il6st-356M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His
    Mouse Il6st-4011M Recombinant Mouse Il6st, His tagged Human Cell His
    Mouse Il6st-6964M Recombinant Mouse Il6st, Fc-His tagged Human Cell Fc/His
    Mouse Il6st-7247M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His
    Mouse Il6st-789M Recombinant Mouse Il6st protein, His & T7-tagged E.coli His/T7
    Rat IL6ST-1882RCL Recombinant Rat IL6ST cell lysate Human Cell N/A
    Rat Il6st-4091R Recombinant Rat Il6st, Fc-His tagged Human Cell Fc/His
    Rat Il6st-4092R Recombinant Rat Il6st, His tagged Human Cell His
    Rat Il6st-539R Recombinant Rat Il6st, Fc Chimera NS0 Fc Chimera
    Rat Il6st-790R Recombinant Rat Il6st protein, His & GST-tagged E.coli His/GST
    Cynomolgus Monkey IL6ST-946CCL Recombinant Cynomolgus IL6ST cell lysate Human Cell N/A
    Rhesus Macaque IL6ST-2255R Recombinant Rhesus monkey IL6ST Protein, His-tagged Mammalian Cell His
    Chicken IL6ST-6434C Recombinant Chicken IL6ST Mammalian Cell His
    Zebrafish IL6ST-6303Z Recombinant Zebrafish IL6ST Mammalian Cell His

    il6st involved in several pathways and played different roles in them. We selected most pathways il6st participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il6st were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL10RA; LEPA; IL6; IL28A; CSF1R; CCR8; Ifna15; HGF; KDRL; IFN-a
    Signaling pathways regulating pluripotency of stem cells IGF1R; PCGF5; KLF4; SKIL; FGFR3; ACVR1; SMAD4; SMAD1; BMPR1B; PCGF6
    Jak-STAT signaling pathway STAT6; STAT2; IL28RA; CRFB2; STAT1; FHL1B; SOCS7; IL2RA; CCND1; IL19
    Viral carcinogenesis CREB3L1; STAT5B; HDAC2; RHOA; IL6ST; MAPK1; BAK1; CREB5; HIST1H2BC; MRPS18B

    il6st has several biochemical functions, for example, ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by il6st itself. We selected most functions il6st had, and list some proteins which have the same functions with il6st. You can find most of the proteins on our site.

    Function Related Protein
    ciliary neurotrophic factor receptor activity IL6ST
    ciliary neurotrophic factor receptor binding LIFR; IL6ST; CNTF; CLCF1; Ctf2
    growth factor binding FGFBP2; NKD2; SDCBP; NRP1; IGFBP2B; HTRA1A; GHRHR; ACVR2B; RHBDF2; REG3B
    contributes_to growth factor binding ACVR1B; ERBB2; TGFBR1; IL6ST
    interleukin-11 binding IL6ST
    interleukin-11 receptor activity IL6ST
    interleukin-27 receptor activity IL27RA; IL6ST
    contributes_to interleukin-6 binding IL6ST
    contributes_to interleukin-6 receptor activity Il6ra; IL6ST; IL6R
    contributes_to interleukin-6 receptor binding IL6; IL6R; IL6ST; Il6ra
    contributes_to leukemia inhibitory factor receptor activity IL6ST; LIFR
    contributes_to oncostatin-M receptor activity OSMR; IL6ST; LIFR
    protein binding GPR37; ADRA2C; MOB4; PPP1R7; SGCA; GSTM4; NIPAL1; TNNI2; VARS; CORO1C
    protein homodimerization activity GPD1B; SMAD3; SEPT12; INHBB; LSM1; ZBTB4; Pdgfa&Pdgfb; DROSHA; CHEK2; PFKM

    il6st has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il6st here. Most of them are supplied by our site. Hope this information will be useful for your research of il6st.

    Stat3; LIF; K2; STAT1; OSM; CNTF; vIL-6; ptpn11-cerae-protein; IL6


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