IL6ST Protein


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Official Full Name Interleukin 6 signal transducer (gp130, oncostatin M receptor)
Background Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
Synonyms IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer (gp130, oncostatin M receptor)
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • DDDDK
    • ENLYFQ
    • Fc
    • Fc Chimera
    • His
    • GST
    • hFc
    • S
    • T7
    • human
    • IgG1
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Il6st-173M Recombinant Mouse Il6st protein, His-tagged HEK293 His
    Human IL6ST-1622H Recombinant Human IL6ST, Fc-His Mammalian cells Fc/His
    Human IL6ST-1682H Recombinant Human IL6ST Sf21 Insect Cell N/A
    Human IL6ST-26366TH Recombinant Human IL6ST Wheat Germ N/A
    Human IL6ST-265H Recombinant Human IL6ST Protein, Fc-tagged HEK293 Fc
    Human IL6ST-271H Recombinant Human IL6ST, ENLYFQ tagged Human Cell His
    Human IL6ST-787H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-788H Recombinant Human IL6ST protein, His-tagged E.coli His
    Mouse Il6st-1743M Recombinant Mouse Interleukin 6 Signal Transducer, Fc-His Mammalian cells Fc
    Mouse Il6st-2208M Recombinant Mouse Il6st, Fc-His tagged CHO Fc/His
    Mouse Il6st-222M Recombinant Mouse Il6st protein, His/S-tagged E.coli His/S
    Mouse Il6st-356M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His
    Mouse Il6st-4011M Recombinant Mouse Il6st, His tagged Human Cell His
    Mouse Il6st-6964M Recombinant Mouse Il6st, Fc-His tagged Human Cell Fc/His
    Mouse Il6st-789M Recombinant Mouse Il6st protein, His & T7-tagged E.coli His/T7
    Rat Il6st-4091R Recombinant Rat Il6st, Fc-His tagged Human Cell Fc/His
    Rat Il6st-4092R Recombinant Rat Il6st, His tagged Human Cell His
    Rat Il6st-539R Recombinant Rat Il6st, Fc Chimera Mammalian cells Fc Chimera
    Rat Il6st-790R Recombinant Rat Il6st protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque IL6ST-2255R Recombinant Rhesus monkey IL6ST Protein, His-tagged Mammalian Cell His
    Chicken IL6ST-6434C Recombinant Chicken IL6ST Mammalian Cell His
    Zebrafish IL6ST-6303Z Recombinant Zebrafish IL6ST Mammalian Cell His
    Human IL6ST-935HCL Recombinant Human IL6ST cell lysate Human Cell N/A
    Mouse IL6ST-001MCL Recombinant Mouse IL6ST cell lysate CHO N/A
    Rat IL6ST-1882RCL Recombinant Rat IL6ST cell lysate Human Cell N/A
    Cynomolgus Monkey IL6ST-946CCL Recombinant Cynomolgus IL6ST cell lysate Human Cell N/A
    Human IL6ST-1055H Recombinant Human IL6ST Protein, His-tagged HEK293F N-His
    Rhesus IL6ST-162R Recombinant Rhesus IL6ST Protein, hFc-tagged HEK293 hFc
    Human IL6ST-182H Recombinant Human IL6ST Protein, ENLYFQ-tagged, Biotinylated HEK293 ENLYFQ
    Human IL6ST-263H Recombinant Human IL6ST Protein, ENLYFQ-tagged HEK293 ENLYFQ
    Human IL6ST-272H Recombinant Human IL6ST protein, DDDDK-tagged HEK293 DDDDK
    Human IL6ST-3170H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-5171H Recombinant Human IL6ST Protein, GST-tagged Wheat Germ GST
    Mouse IL6ST-353M Recombinant Mouse IL6ST protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Il6st-7247M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His

    IL6ST involved in several pathways and played different roles in them. We selected most pathways IL6ST participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6ST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL22RA2; IFNG1-2; VEGFAA; TGFB2; Ifna11; IL17RB; CRFB16; IL26; IL8L2; IL2RGA
    Signaling pathways regulating pluripotency of stem cells AXIN1; PIK3CA; FGF2; MAPK11; Fzd4; TBX3; AXIN2; IGF1; TCF3; APC
    Jak-STAT signaling pathway IFNA10; IFNE; IFNG1-2; AKT2L; IL22; PRP2; SOCS1; IFNB1; IL13; STAT5A
    Viral carcinogenesis CREB5; TTC6; TRAF2; HIST1H2BK; NRAS; CCNE1; CCNE2; HIST2H4; HIST1H2BH; KAT2B

    IL6ST has several biochemical functions, for example, ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6ST itself. We selected most functions IL6ST had, and list some proteins which have the same functions with IL6ST. You can find most of the proteins on our site.

    Function Related Protein
    ciliary neurotrophic factor receptor activity IL6ST
    ciliary neurotrophic factor receptor binding CLCF1; CNTF; IL6ST; LIFR; Ctf2
    growth factor binding OSMR; REG3B; GHR; NRP1; ACVR2A; BMPR2; IGFBP2A; HTRA1B; FLT4; RHBDF1
    contributes_to growth factor binding ACVR1B; IL6ST; ERBB2; TGFBR1
    interleukin-11 binding IL6ST
    interleukin-11 receptor activity IL6ST
    interleukin-27 receptor activity IL6ST; IL27RA
    contributes_to interleukin-6 binding IL6ST
    contributes_to interleukin-6 receptor activity IL6R; Il6ra; IL6ST
    contributes_to interleukin-6 receptor binding IL6; IL6R; IL6ST; Il6ra
    contributes_to leukemia inhibitory factor receptor activity LIFR; IL6ST
    contributes_to oncostatin-M receptor activity IL6ST; LIFR; OSMR
    protein binding TECPR1; PTPRA; PKM2; CD200R2; SNAP91; INHA; RNF111; ATG7; KLF3; JMJD6
    protein homodimerization activity STK25; AMBP; DMRT2A; DMRTC1B; PDK2; GYS2; HELT; LCN2; ABCG1; DPY30

    IL6ST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6ST here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6ST.

    Stat3; LIF; K2; STAT1; OSM; CNTF; vIL-6; ptpn11-cerae-protein; IL6


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