IL6ST
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Official Full Name
Interleukin 6 signal transducer (gp130, oncostatin M receptor)
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Background
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion. -
Synonyms
IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer (gp130, oncostatin M receptor);
- Involved Pathway
- Protein Function
- Interacting Protein
- IL6ST Related Gene Family
- IL6ST Related Research Area
IL6ST involved in several pathways and played different roles in them. We selected most pathways IL6ST participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6ST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF4;IFNGR2;EDAR;IL28A;CXCL10;CXCR2;IL22;CCL27B;IL18RAP |
| Signaling pathways regulating pluripotency of stem cells | PAX6;FZD9;PIK3R3;TBX3;WNT8B;SMAD2;POU5F1;STAT3;MAPK3 |
| Jak-STAT signaling pathway | IL4R;GM-CSF;IL13RA2;CISH;CCND2A;CSF3R;PIM1;PTPN11B;GM13305 |
| Viral carcinogenesis | SCIN;HIST1H2BM;HIST1H2BE;ATF4;TRAF2;NFKB2;RB1;PMAIP1;MRPS18B |
IL6ST has several biochemical functions, for example, ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6ST itself. We selected most functions IL6ST had, and list some proteins which have the same functions with IL6ST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ciliary neurotrophic factor receptor activity | |
| ciliary neurotrophic factor receptor binding | IL6ST;Ctf2;LIFR;CNTF;CLCF1 |
| growth factor binding | LTBP4;NRP2;ACVR1C;RHBDF2;TEK;HTRA1A;KDR;NRP1;ACVR2B |
| contributes_to growth factor binding | IL6ST;ACVR1B;TGFBR1;ERBB2 |
| interleukin-11 binding | |
| interleukin-11 receptor activity | |
| interleukin-27 receptor activity | IL27RA;IL6ST |
| contributes_to interleukin-6 binding | |
| contributes_to interleukin-6 receptor activity | IL6ST;IL6R;Il6ra |
| contributes_to interleukin-6 receptor binding | IL6;IL6ST;Il6ra;IL6R |
| contributes_to leukemia inhibitory factor receptor activity | IL6ST;LIFR |
| contributes_to oncostatin-M receptor activity | OSMR;LIFR;IL6ST |
| protein binding | OLIG3;KIF21A;ERRFI1;ABCG2;UBE4A;KCNA4;C21orf56;RFX1;TGFBR1 |
| protein homodimerization activity | SNX6;RAG1;TESC;Bcl2a1b;ACTN1;CTBP2;SYNE1;NADKD1;GZMA |
IL6ST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6ST here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6ST.
Stat3; LIF; K2; STAT1; OSM; CNTF; vIL-6; ptpn11-cerae-protein; IL6
- Q&As
- Reviews
Q&As (6)
Ask a questionThe activity of IL6ST is usually detected by cell differentiation and proliferation assay.
IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.
IL6ST is involved in various inflammatory responses and cell differentiation processes.
The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.
The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.
The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.
Customer Reviews (3)
Write a reviewIL6ST can be customized through genetic engineering techniques, including selecting specific expression hosts, tagging proteins, and altering its structure. This enables IL6ST to meet specific research needs and to be tailored for use in the laboratory. -
The stability of IL6ST under different temperature, pH value and other conditions is tested by thermal stability experiment and other methods, and its stability in storage and use is evaluated. -
Secondary structure of IL6ST were studied by X-ray crystal diffraction, spectral analysis and other techniques to understand its function and interaction with other molecules. -
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