IL6ST

  • Official Full Name

    Interleukin 6 signal transducer (gp130, oncostatin M receptor)

  • Background

    Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
  • Synonyms

    IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer (gp130, oncostatin M receptor);
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • DDDDK
    • ENLYFQ
    • Fc
    • Fc Chimera
    • Fc|His
    • GST
    • hFc
    • His
    • His (Fc)
    • Avi
    • mFc
    • His|GST
    • His|S
    • His|T7
    • human|IgG1|Fc
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken IL6ST-6434C Recombinant Chicken IL6ST Mammalian Cell His
    Cynomolgus Monkey IL6ST-946CCL Recombinant Cynomolgus IL6ST cell lysate Human Cell N/A
    Human IL6ST-1682H Recombinant Human IL6ST Sf21 Insect Cell N/A
    Human IL6ST-1622H Recombinant Human IL6ST, Fc-His Mammalian cells Fc/His
    Human IL6ST-935HCL Recombinant Human IL6ST cell lysate Human Cell N/A
    Human IL6ST-787H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-26366TH Recombinant Human IL6ST Wheat Germ N/A
    Human IL6ST-788H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-271H Recombinant Human IL6ST, ENLYFQ tagged Human Cell His
    Human IL6ST-3170H Recombinant Human IL6ST protein, His-tagged E.coli His
    Human IL6ST-182H Recombinant Human IL6ST Protein, ENLYFQ-tagged, Biotinylated HEK293 ENLYFQ
    Human IL6ST-5171H Recombinant Human IL6ST Protein, GST-tagged Wheat Germ GST
    Human IL6ST-265H Recombinant Human IL6ST Protein, Fc-tagged HEK293 Fc
    Human IL6ST-272H Recombinant Human IL6ST protein, DDDDK-tagged HEK293 DDDDK
    Human IL6ST-1055H Recombinant Human IL6ST Protein, His-tagged HEK293F N-His
    Human IL6ST-225H Recombinant Human IL6ST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL6ST-263H Recombinant Human IL6ST Protein, ENLYFQ-tagged HEK293 ENLYFQ
    Human IL6ST-225H-B Recombinant Human IL6ST Protein Pre-coupled Magnetic Beads HEK293
    Human IL6ST-1300H Recombinant Human IL6ST protein, His-tagged HEK293 His
    Human IL6ST-0298H Recombinant Human IL6ST protein HEK293 N/A
    Mouse Il6st-78M Recombinant Mouse Il6st Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il6st-789M Recombinant Mouse Il6st protein, His & T7-tagged E.coli His/T7
    Mouse Il6st-7247M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His
    Mouse Il6st-78M-B Recombinant Mouse Il6st Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il6st-274M Recombinant Mouse Il6st Protein, His-tagged HEK293 His
    Mouse IL6ST-1531M Recombinant Mouse IL6ST protein, Fc-tagged HEK293 Fc
    Mouse Il6st-173M Recombinant Mouse Il6st protein, His-tagged HEK293 His
    Mouse IL6ST-353M Recombinant Mouse IL6ST protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Il6st-275M Recombinant Mouse Il6st Protein, Fc-tagged HEK293 Fc
    Mouse Il6st-2208M Recombinant Mouse Il6st, Fc-His tagged CHO Fc/His
    Mouse Il6st-1743M Recombinant Mouse Interleukin 6 Signal Transducer, Fc-His Mammalian cells Fc
    Mouse IL6ST-001MCL Recombinant Mouse IL6ST cell lysate CHO N/A
    Mouse Il6st-356M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His
    Mouse Il6st-6964M Recombinant Mouse Il6st, Fc-His tagged Human Cell Fc/His
    Mouse Il6st-222M Recombinant Mouse Il6st protein, His/S-tagged E.coli His/S
    Mouse Il6st-4011M Recombinant Mouse Il6st, His tagged Human Cell His
    Rat Il6st-26R Recombinant Rat Il6st Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat IL6ST-1882RCL Recombinant Rat IL6ST cell lysate Human Cell N/A
    Rat IL6ST-1964R Recombinant Rat IL6ST protein, His&mFc-tagged HEK293 His&mFc
    Rat Il6st-539R Active Recombinant Rat Il6st, Fc Chimera Mammalian cells Fc Chimera
    Rat Il6st-4091R Recombinant Rat Il6st, Fc-His tagged Human Cell Fc/His
    Rat Il6st-4092R Recombinant Rat Il6st, His tagged Human Cell His
    Rat Il6st-790R Recombinant Rat Il6st protein, His & GST-tagged E.coli His/GST
    Rat Il6st-26R-B Recombinant Rat Il6st Protein Pre-coupled Magnetic Beads HEK293
    Rhesus IL6ST-162R Recombinant Rhesus IL6ST Protein, hFc-tagged HEK293 hFc
    Rhesus IL6ST-225R Recombinant Rhesus IL6ST protein, His-tagged HEK293 His
    Rhesus Macaque IL6ST-2076R Recombinant Rhesus Macaque IL6ST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque IL6ST-2076R-B Recombinant Rhesus Macaque IL6ST Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL6ST-2255R Recombinant Rhesus monkey IL6ST Protein, His-tagged Mammalian Cell His
    Zebrafish IL6ST-6303Z Recombinant Zebrafish IL6ST Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL6ST Related Gene Family
    • IL6ST Related Research Area

    IL6ST involved in several pathways and played different roles in them. We selected most pathways IL6ST participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6ST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionTNFRSF4;IFNGR2;EDAR;IL28A;CXCL10;CXCR2;IL22;CCL27B;IL18RAP
    Signaling pathways regulating pluripotency of stem cellsPAX6;FZD9;PIK3R3;TBX3;WNT8B;SMAD2;POU5F1;STAT3;MAPK3
    Jak-STAT signaling pathwayIL4R;GM-CSF;IL13RA2;CISH;CCND2A;CSF3R;PIM1;PTPN11B;GM13305
    Viral carcinogenesisSCIN;HIST1H2BM;HIST1H2BE;ATF4;TRAF2;NFKB2;RB1;PMAIP1;MRPS18B

    IL6ST has several biochemical functions, for example, ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6ST itself. We selected most functions IL6ST had, and list some proteins which have the same functions with IL6ST. You can find most of the proteins on our site.

    Function Related Protein
    ciliary neurotrophic factor receptor activity
    ciliary neurotrophic factor receptor bindingIL6ST;Ctf2;LIFR;CNTF;CLCF1
    growth factor bindingLTBP4;NRP2;ACVR1C;RHBDF2;TEK;HTRA1A;KDR;NRP1;ACVR2B
    contributes_to growth factor bindingIL6ST;ACVR1B;TGFBR1;ERBB2
    interleukin-11 binding
    interleukin-11 receptor activity
    interleukin-27 receptor activityIL27RA;IL6ST
    contributes_to interleukin-6 binding
    contributes_to interleukin-6 receptor activityIL6ST;IL6R;Il6ra
    contributes_to interleukin-6 receptor bindingIL6;IL6ST;Il6ra;IL6R
    contributes_to leukemia inhibitory factor receptor activityIL6ST;LIFR
    contributes_to oncostatin-M receptor activityOSMR;LIFR;IL6ST
    protein bindingOLIG3;KIF21A;ERRFI1;ABCG2;UBE4A;KCNA4;C21orf56;RFX1;TGFBR1
    protein homodimerization activitySNX6;RAG1;TESC;Bcl2a1b;ACTN1;CTBP2;SYNE1;NADKD1;GZMA

    IL6ST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6ST here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6ST.

    Stat3; LIF; K2; STAT1; OSM; CNTF; vIL-6; ptpn11-cerae-protein; IL6

    IL
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    How to detect IL6ST activity? 04/26/2022

    The activity of IL6ST is usually detected by cell differentiation and proliferation assay.

    In what diseases does IL6ST have applications? 04/20/2021

    IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.

    Are there any effects of IL6ST on cell differentiation? 04/15/2021

    IL6ST is involved in various inflammatory responses and cell differentiation processes.

    What are the physical and chemical properties of IL6ST? 02/03/2021

    The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.

    Why research IL6ST? 02/09/2019

    The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.

    What is the preparation method of IL6ST? 01/27/2019

    The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.

    Customer Reviews (3)

    Write a review
    Reviews
    02/28/2022

      IL6ST can be customized through genetic engineering techniques, including selecting specific expression hosts, tagging proteins, and altering its structure. This enables IL6ST to meet specific research needs and to be tailored for use in the laboratory. -

      08/04/2020

        The stability of IL6ST under different temperature, pH value and other conditions is tested by thermal stability experiment and other methods, and its stability in storage and use is evaluated. -

        09/06/2019

          Secondary structure of IL6ST were studied by X-ray crystal diffraction, spectral analysis and other techniques to understand its function and interaction with other molecules. -

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