IL6ST
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Official Full Name
Interleukin 6 signal transducer (gp130, oncostatin M receptor) -
Overview
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion. -
Synonyms
IL6ST;CD130;CDW130;GP130;IL-6RB;Interleukin 6 signal transducer (gp130, oncostatin M receptor)
Recombinant Proteins
- Mouse
- Rat
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Cynomolgus
- HEK293
- CHO
- Human Cells
- E.coli
- Mammalian Cells
- Sf21 Cells
- Wheat Germ
- Insect Cells
- HEK293T
- His
- Fc
- mFc
- Non
- S
- T7
- GST
- Avi
- Flag
Involved Pathway
IL6ST involved in several pathways and played different roles in them. We selected most pathways IL6ST participated on our site, such as Cytokine-cytokine receptor interaction,Signaling pathways regulating pluripotency of stem cells,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6ST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IL20,IFNA5,IL22RA2,Fasl,XCR1,CCL15,PDGFB,IL18R1,TNFRSF12A,IL3RA |
| Viral carcinogenesis | MAPK3,PIK3R3,RELA,CCNE2,C3,CREB5,RBL2,HIST1H2BM,PXN,CCNA2 |
| Signaling pathways regulating pluripotency of stem cells | INHBA,GRB2,FZD9,PIK3R5,WNT4,BMP2,MAPK1,BMPR1B,ESRRB,MAPK13 |
| Jak-STAT signaling pathway | IFNGR1,PIK3R3B,AKT1,STAT1,IL4R,IFNW1,PTPN2,IL19,RNF207B,CRLF2 |
Protein Function
IL6ST has several biochemical functions, for example, ciliary neurotrophic factor receptor activity,ciliary neurotrophic factor receptor binding,growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6ST itself. We selected most functions IL6ST had, and list some proteins which have the same functions with IL6ST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-27 receptor activity | IL27RA |
| protein binding | NPHS1,CASP2,CAV2,BRE,POP7,VTI1B,HOOK1,SHMT1,MRPL44,LPXN |
| contributes_to growth factor binding | TGFBR1,ACVR1B,ERBB2 |
| contributes_to interleukin-6 receptor binding | IL6,IL6R,Il6ra |
| protein homodimerization activity | RAB11FIP2,ENPP1,IZUMO1,NTSR1,SNX6,TESCA,TENM1,KCNK3,CADM2A,ADAM10 |
| contributes_to interleukin-6 receptor activity | IL6R,Il6ra |
| contributes_to oncostatin-M receptor activity | LIFR,OSMR |
| growth factor binding | IGFBP2A,FGFBP2,NKD2,NRP1,NRP2,ACVR2B,OSMR,GHRHR,FLT4,RHBDF2 |
| ciliary neurotrophic factor receptor binding | CNTF,Ctf2,LIFR,CLCF1 |
Interacting Protein
IL6ST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6ST here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6ST.
Stat3;LIF;K2;STAT1;OSM;CNTF;vIL-6;ptpn11-cerae-protein;IL6
Resources
Research Area
VPS10P-domain FamilyNegative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
T Cell Cytokine Signaling
CD Antigen (Helper T Cells)
T Follicular Helper (Tfh) Cells
Th1 Cells
Th17 Cells
IL-12 Family Receptors
IL-6 Family Receptors
MDSC Phenotyping - Positive Markers
Related Services
Related Products
References
