• Official Full Name

    Interleukin 6 signal transducer (gp130, oncostatin M receptor)

  • Overview

    Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
  • Synonyms

    IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer (gp130, oncostatin M receptor);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • Fc
  • Fc Chimera
  • Fc|His
  • GST
  • His (Fc)
  • Avi
  • mFc
  • His|GST
  • His|S
  • His|T7
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL6ST-1380H Acitve Recombinant Human IL6ST protein(Met1-Ile618), His&hFc-tagged HEK293 C-His&hFc Met1-Ile618
Human IL6ST-1682H Recombinant Human IL6ST Sf21 Insect Cell N/A
Human IL6ST-787H Recombinant Human IL6ST protein, His-tagged E.coli His Thr392~Leu566 (Accession # P40189)
Human IL6ST-271H Recombinant Human IL6ST, ENLYFQ tagged Human Cell His
Human IL6ST-1622H Recombinant Human IL6ST, Fc-His Mammalian cells Fc/His
Human IL6ST-26366TH Recombinant Human IL6ST Wheat Germ N/A 100 amino acids
Human IL6ST-788H Recombinant Human IL6ST protein, His-tagged E.coli His Ser606~Gln756
Human IL6ST-265H Recombinant Human IL6ST Protein, Fc-tagged HEK293 Fc
Human IL6ST-935HCL Recombinant Human IL6ST cell lysate Human Cell N/A
Human IL6ST-3170H Recombinant Human IL6ST protein, His-tagged E.coli His 124-369 aa
Human IL6ST-182H Recombinant Human IL6ST Protein, ENLYFQ-tagged, Biotinylated HEK293 ENLYFQ Met1-Ile618
Human IL6ST-5171H Recombinant Human IL6ST Protein, GST-tagged Wheat Germ GST
Human IL6ST-1300H Active Recombinant Human IL6ST protein, His-tagged HEK293 His Glu23-Glu619
Human IL6ST-272H Recombinant Human IL6ST protein, DDDDK-tagged HEK293 DDDDK Met1-Ile618
Human IL6ST-1055H Recombinant Human IL6ST Protein, His-tagged HEK293F N-His Thr392-Leu566
Human IL6ST-225H Recombinant Human IL6ST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL6ST-0298H Recombinant Human IL6ST protein HEK293 N/A Met1-Ile618
Human IL6ST-2749H Recombinant Human IL6ST protein(771-910 aa), C-His-tagged E.coli C-His 771-910 aa
Human IL6ST-2878H Recombinant Human IL6ST Protein (Thr392-Thr566), His tagged E.coli His Thr392-Thr566
Human IL6ST-2751H Recombinant Human IL6ST protein(651-910 aa), C-His-tagged E.coli C-His 651-910 aa
Human IL6ST-4288H Recombinant Human IL6ST Protein (Met1-Glu619), C-His tagged Mammalian cells C-His Met1-Glu619
Human IL6ST-225H-B Recombinant Human IL6ST Protein Pre-coupled Magnetic Beads HEK293
Human IL6ST-2750H Recombinant Human IL6ST protein(691-860 aa), C-His-tagged E.coli C-His 691-860 aa
Human IL6ST-263H Recombinant Human IL6ST Protein, ENLYFQ-tagged HEK293 ENLYFQ Met1-Ile618
Mouse Il6st-173M Recombinant Mouse Il6st protein, His-tagged HEK293 His Gln23-Glu617
Mouse Il6st-2208M Recombinant Mouse Il6st, Fc-His tagged CHO Fc/His
Mouse Il6st-356M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His
Mouse Il6st-4011M Recombinant Mouse Il6st protein(Met1-Glu617), His-tagged HEK293 C-His Met1-Glu617
Mouse Il6st-1743M Recombinant Mouse Interleukin 6 Signal Transducer, Fc-His Mammalian cells Fc
Mouse Il6st-6964M Recombinant Mouse Il6st, Fc-His tagged Human Cell Fc/His
Mouse Il6st-222M Recombinant Mouse Il6st protein, His/S-tagged E.coli His/S
Mouse Il6st-789M Recombinant Mouse Il6st protein, His & T7-tagged E.coli His/T7 Leu238~Thr500
Mouse IL6ST-001MCL Recombinant Mouse IL6ST cell lysate CHO N/A
Mouse Il6st-7247M Recombinant Mouse Il6st Protein, His-tagged Insect Cell His 23-617
Mouse IL6ST-1531M Active Recombinant Mouse IL6ST protein(Met1-Glu617), hFc-tagged HEK293 C-hFc Met1-Glu617
Mouse Il6st-78M Recombinant Mouse Il6st Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IL6ST-353M Recombinant Mouse IL6ST protein, Fc-tagged HEK293 human/IgG1/Fc 595
Mouse Il6st-274M Recombinant Mouse Il6st Protein, His-tagged HEK293 His 917
Mouse Il6st-78M-B Recombinant Mouse Il6st Protein Pre-coupled Magnetic Beads HEK293
Mouse Il6st-275M Recombinant Mouse Il6st Protein, Fc-tagged HEK293 Fc 917
Rat Il6st-539R Active Recombinant Rat Il6st, Fc Chimera Mammalian cells Fc Chimera
Rat IL6ST-1964R Active Recombinant Rat IL6ST protein, His&mFc-tagged HEK293 His&mFc Met4-Glu618
Rat Il6st-4091R Recombinant Rat Il6st, Fc-His tagged Human Cell Fc/His
Rat Il6st-4092R Active Recombinant Rat Il6st protein(Met4-Glu618), His-tagged HEK293 C-His Met4-Glu618
Rat Il6st-790R Recombinant Rat Il6st protein, His & GST-tagged E.coli His/GST Glu26~Asp323 (Accession # P40190)
Rat IL6ST-1882RCL Recombinant Rat IL6ST cell lysate Human Cell N/A
Rat Il6st-26R Recombinant Rat Il6st Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Il6st-26R-B Recombinant Rat Il6st Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IL6ST-946CCL Recombinant Cynomolgus IL6ST cell lysate Human Cell N/A
Rhesus IL6ST-162R Recombinant Rhesus IL6ST Protein, hFc-tagged HEK293 hFc Met1-Ile618
Rhesus IL6ST-225R Recombinant Rhesus IL6ST protein, His-tagged HEK293 His Met1-Ile681
Rhesus Macaque IL6ST-2255R Recombinant Rhesus monkey IL6ST Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL6ST-2076R Recombinant Rhesus Macaque IL6ST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IL6ST-2076R-B Recombinant Rhesus Macaque IL6ST Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IL6ST-6303Z Recombinant Zebrafish IL6ST Mammalian Cell His
Chicken IL6ST-6434C Recombinant Chicken IL6ST Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL6ST involved in several pathways and played different roles in them. We selected most pathways IL6ST participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6ST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionLOC100033925;CXCL3;ACVR1L;IL4;PDGFRA;CCL19;Ifna15;Pdgfa&Pdgfb;BMP7B
Signaling pathways regulating pluripotency of stem cellsAXIN1;PAX6;MAP2K2;POU5F1;MAPK12;ACVR2A;FGFR3;REST;WNT9A
Jak-STAT signaling pathwayIFNA6;IL3RA;PIK3R3A;IL9;AOX4;IFNA4;SOCS9;IL11RA2;CSF3R

IL6ST has several biochemical functions, for example, ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6ST itself. We selected most functions IL6ST had, and list some proteins which have the same functions with IL6ST. You can find most of the proteins on our site.

Function Related Protein
ciliary neurotrophic factor receptor activity
ciliary neurotrophic factor receptor bindingCNTF;LIFR;Ctf2;CLCF1;IL6ST
contributes_to growth factor bindingIL6ST;ACVR1B;TGFBR1;ERBB2
interleukin-11 binding
interleukin-11 receptor activity
interleukin-27 receptor activityIL27RA;IL6ST
contributes_to interleukin-6 binding
contributes_to interleukin-6 receptor activityIl6ra;IL6R;IL6ST
contributes_to interleukin-6 receptor bindingIL6ST;IL6R;Il6ra;IL6
contributes_to leukemia inhibitory factor receptor activityIL6ST;LIFR
contributes_to oncostatin-M receptor activityIL6ST;LIFR;OSMR
protein homodimerization activityHMGCR;ZBTB1;IRF3;RBM44;ALDH1A3;MVD;ECT2;PLOD1;TCF3B

IL6ST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6ST here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6ST.

Stat3; LIF; K2; STAT1; OSM; CNTF; vIL-6; ptpn11-cerae-protein; IL6

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How to detect IL6ST activity? 04/26/2022

The activity of IL6ST is usually detected by cell differentiation and proliferation assay.

In what diseases does IL6ST have applications? 04/20/2021

IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.

Are there any effects of IL6ST on cell differentiation? 04/15/2021

IL6ST is involved in various inflammatory responses and cell differentiation processes.

What are the physical and chemical properties of IL6ST? 02/03/2021

The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.

Why research IL6ST? 02/09/2019

The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.

What is the preparation method of IL6ST? 01/27/2019

The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.

Customer Reviews (3)

Write a review

    IL6ST proteins can be functionally enhanced or altered by protein modification techniques.


      As an immunotherapy drug, it has good effect and high safety.


        Has a good inhibitory effect on cell proliferation and survival.

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