| Description : |
Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). |
| Source : |
HEK293 |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
86.2 kDa |
| Protein Length : |
862 |
| AA Sequence : |
MSTADLMRRWVIALLLAAAGVAAED SCSRNEFQCRDGKCIASKWVCDGSP ECPDGSDESPETCMSVTCQSNQFSC GGRVSRCIPDSWRCDGQVDCENDSD EQGCPPKTCSQDDFRCQDGKCISPQ FVCDGDRDCLDGSDEAHCQATTCGP AHFRCNSSICIPSLWACDGDVDCVD GSDEWPQNCQGRDTASKGVSSPCSS LEFHCGSSECIHRSWVCDGEADCKD KSDEEHCAVATCRPDEFQCADGSCI HGSRQCDREHDCKDMSDELGCVNVT QCDGPNKFKCHSGECISLDKVCDSA RDCQDWSDEPIKECKTNECLDNNGG CSHICKDLKIGSECLCPSGFRLVDL HRCEDIDECQEPDTCSQLCVNLEGS YKCECQAGFHMDPHTRVCKAVGSIG YLLFTNRHEVRKMTLDRSEYTSLLP NLKNVVALDTEVTNNRIYWSDLSQK KIYSALMDQAPNLSYDTIISEDLHA PDGLAVDWIHRNIYWTDSVPGSVSV ADTKGVKRRTLFQEAGSRPRAIVVD PVHGFMYWTDWGTPAKIKKGGLNGV DIHSLVTENIQWPNGITLDLSSGRL YWVDSKLHSISSIDVNGGNRKTILE DENRLAHPFSLAIYEDKVYWTDVIN EAIFSANRLTGSDVNLVAENLLSPE DIVLFHKVTQPRGVNWCETTALLPN GGCQYLCLPAPQIGPHSPKFTCACP DGMLLAKDMRSCLTEVDTVLTTQGT SAVRPVVTASATRPPKHSEDLSAPS TPRQPVDTPGLSTVASVTVSHQVQG DMAGRGNEEQPHGMRFLSIFFPIAL VALLVLGAVLLWRNWRLKNINSINF DNPVYQKTTEDELHICRSQDGYTYP SRQMVSLEDDVA |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
