Recombinant Mouse Ldlr Protein, His-tagged

• Cat.No.: Ldlr-349M
• Product Overview: Recombinant Mouse Ldlr protein with His tag was expressed in HEK293.

Specification

• Description: Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Molecular Mass: 86.2 kDa
• Protein length: 862
• AA Sequence: MSTADLMRRWVIALLLAAAGVAAED SCSRNEFQCRDGKCIASKWVCDGSP ECPDGSDESPETCMSVTCQSNQFSC GGRVSRCIPDSWRCDGQVDCENDSD EQGCPPKTCSQDDFRCQDGKCISPQ FVCDGDRDCLDGSDEAHCQATTCGP AHFRCNSSICIPSLWACDGDVDCVD GSDEWPQNCQGRDTASKGVSSPCSS LEFHCGSSECIHRSWVCDGEADCKD KSDEEHCAVATCRPDEFQCADGSCI HGSRQCDREHDCKDMSDELGCVNVT QCDGPNKFKCHSGECISLDKVCDSA RDCQDWSDEPIKECKTNECLDNNGG CSHICKDLKIGSECLCPSGFRLVDL HRCEDIDECQEPDTCSQLCVNLEGS YKCECQAGFHMDPHTRVCKAVGSIG YLLFTNRHEVRKMTLDRSEYTSLLP NLKNVVALDTEVTNNRIYWSDLSQK KIYSALMDQAPNLSYDTIISEDLHA PDGLAVDWIHRNIYWTDSVPGSVSV ADTKGVKRRTLFQEAGSRPRAIVVD PVHGFMYWTDWGTPAKIKKGGLNGV DIHSLVTENIQWPNGITLDLSSGRL YWVDSKLHSISSIDVNGGNRKTILE DENRLAHPFSLAIYEDKVYWTDVIN EAIFSANRLTGSDVNLVAENLLSPE DIVLFHKVTQPRGVNWCETTALLPN GGCQYLCLPAPQIGPHSPKFTCACP DGMLLAKDMRSCLTEVDTVLTTQGT SAVRPVVTASATRPPKHSEDLSAPS TPRQPVDTPGLSTVASVTVSHQVQG DMAGRGNEEQPHGMRFLSIFFPIAL VALLVLGAVLLWRNWRLKNINSINF DNPVYQKTTEDELHICRSQDGYTYP SRQMVSLEDDVA
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: Ldlr low density lipoprotein receptor [ Mus musculus (house mouse) ]
• Official Symbol: Ldlr
• Synonyms: LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; LDL receptor; Hlb301
• Gene ID: 16835
• mRNA Refseq: NM_001252658
• Protein Refseq: NP_001239587
• UniProt ID: P35951

Reviews

08/11/2020

The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

10/07/2018

Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

03/04/2017

the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

Q&As

Are there conditions where upregulation of LDLR might be beneficial?

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications?

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction?

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis?

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions?

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.