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Active Recombinant Mouse Src protein(Met1-Leu535), His&GST-tagged

Cat.No. : Src-907M
Product Overview : Recombinant Mouse SRC (NP_001020566.111) (Met 1-Leu 535) was expressed in Insect Cells, fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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  • Gene Information
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Source : Insect Cells
Species : Mouse
Tag : N-His&GST
Protein length : Met1-Leu535
Form : Supplied as sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.0.
Bio-activity : 1. The specific activity was determined to be >80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substRate. 2. Measured by its binding ability in a functional ELISA. Immobilized recombinant Mouse SRC at 2 μg/ml (100 μl/well) can bind biotinylated human PTPRA (aa 174-793) with a linear range of 0.032-0.8 μg/ml.
Molecular Mass : The recombinant mouse SRC/GST chimera consists of 773 amino acids and has a calculated molecular mass of 87.7 kDa. It migRates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 90 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Src Rous sarcoma oncogene [ Mus musculus ]
Official Symbol : Src
Synonyms : SRC; Rous sarcoma oncogene; neuronal proto-oncogene tyrosine-protein kinase Src; p60-Src; proto-oncogene c-Src; AW259666; pp60c-src;
Gene ID : 20779
mRNA Refseq : NM_001025395
Protein Refseq : NP_001020566

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

Customer Reviews (3)

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Reviews
01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

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