Recombinant Human SRC protein, His-tagged
Cat.No. : | SRC-22H |
Product Overview : | Recombinant Human SRC(1-536aa) fused with His tag was expressed in E. coli. |
Availability | February 11, 2025 |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. |
AA Sequence : | MGSNKSKPKDASQRRRSLEPAENVH GAGGGAFPASQTPSKPASADGHRGP SAAFAPAAAEPKLFGGFNSSDTVTS PQRAGPLAGGVTTFVALYDYESRTE TDLSFKKGERLQIVNNTEGDWWLAH SLSTGQTGYIPSNYVAPSDSIQAEE WYFGKITRRESERLLLNAENPRGTF LVRESETTKGAYCLSVSDFDNAKGL NVKHYKIRKLDSGGFYITSRTQFNS LQQLVAYYSKHADGLCHRLTTVCPT SKPQTQGLAKDAWEIPRESLRLEVK LGQGCFGEVWMGTWNGTTRVAIKTL KPGTMSPEAFLQEAQVMKKLRHEKL VQLYAVVSEEPIYIVTEYMSKGSLL DFLKGETGKYLRLPQLVDMAAQIAS GMAYVERMNYVHRDLRAANILVGEN LVCKVADFGLARLIEDNEYTARQGA KFPIKWTAPEAALYGRFTIKSDVWS FGILLTELTTKGRVPYPGMVNREVL DQVERGYRMPCPPECPESLHDLMCQ CWRKEPEERPTFEYLQAFLEDYFTS TEPQYQPGENL |
Purity : | 90%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Stability and Storage: Store for up to 12 months at -20 centigrade to -80 centigrade as lyophilized powder. Storage of Reconstituted Protein: Short-term storage: Store at 2-8 centigrade for two weeks. Long-term storage: Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used). Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. |
Protein length : | 1-536 |
Gene Name : | SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens ] |
Official Symbol : | SRC |
Synonyms : | ASV; SRC1; THC6; c-SRC; p60-Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog |
Gene ID : | 6714 |
mRNA Refseq : | NM_005417 |
Protein Refseq : | NP_005408 |
MIM : | 190090 |
UniProt ID : | P12931 |
Products Types
◆ Recombinant Protein | ||
Src-6122M | Recombinant Mouse Src Protein, Myc/DDK-tagged | +Inquiry |
Src-1367M | Recombinant Mus musculus Src Protein (V85-L535), His-tagged | +Inquiry |
Src-1368M | Recombinant Mus musculus Src Protein (V85-L535) | +Inquiry |
SRC-0403H | Recombinant Human SRC Protein (G2-L536), His/Flag tagged | +Inquiry |
Src-907M | Active Recombinant Mouse Src protein(Met1-Leu535), His&GST-tagged | +Inquiry |
◆ Native Protein | ||
SRC-29697TH | Native Human SRC | +Inquiry |
◆ Lysates | ||
SRC-585MCL | Recombinant Mouse SRC cell lysate | +Inquiry |
SRC-487HCL | Recombinant Human SRC cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewTop-notch protein purification service, essential for our research.
Reliable mass spectrometry analysis, pivotal for our proteomics work.
Swift and reliable protein sequencing, indispensable for our research success.
Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
Ask a Question for All SRC Products
Required fields are marked with *
My Review for All SRC Products
Required fields are marked with *
Inquiry Basket