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Recombinant Human SRC protein, His-tagged

Cat.No. : SRC-22H
Product Overview : Recombinant Human SRC(1-536aa) fused with His tag was expressed in E. coli.
Availability February 11, 2025
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Description : This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Source : E. coli
Species : Human
Tag : His
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
AA Sequence : MGSNKSKPKDASQRRRSLEPAENVH GAGGGAFPASQTPSKPASADGHRGP SAAFAPAAAEPKLFGGFNSSDTVTS PQRAGPLAGGVTTFVALYDYESRTE TDLSFKKGERLQIVNNTEGDWWLAH SLSTGQTGYIPSNYVAPSDSIQAEE WYFGKITRRESERLLLNAENPRGTF LVRESETTKGAYCLSVSDFDNAKGL NVKHYKIRKLDSGGFYITSRTQFNS LQQLVAYYSKHADGLCHRLTTVCPT SKPQTQGLAKDAWEIPRESLRLEVK LGQGCFGEVWMGTWNGTTRVAIKTL KPGTMSPEAFLQEAQVMKKLRHEKL VQLYAVVSEEPIYIVTEYMSKGSLL DFLKGETGKYLRLPQLVDMAAQIAS GMAYVERMNYVHRDLRAANILVGEN LVCKVADFGLARLIEDNEYTARQGA KFPIKWTAPEAALYGRFTIKSDVWS FGILLTELTTKGRVPYPGMVNREVL DQVERGYRMPCPPECPESLHDLMCQ CWRKEPEERPTFEYLQAFLEDYFTS TEPQYQPGENL
Purity : 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Stability and Storage: Store for up to 12 months at -20 centigrade to -80 centigrade as lyophilized powder.
Storage of Reconstituted Protein: Short-term storage: Store at 2-8 centigrade for two weeks.
Long-term storage: Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.
If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used).
Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution.
Protein length : 1-536
Gene Name : SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens ]
Official Symbol : SRC
Synonyms : ASV; SRC1; THC6; c-SRC; p60-Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Gene ID : 6714
mRNA Refseq : NM_005417
Protein Refseq : NP_005408
MIM : 190090
UniProt ID : P12931

Not For Human Consumption!

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Customer Reviews (3)

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01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

        Q&As (7)

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        How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

        Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

        How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

        SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

        How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

        SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

        What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

        SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

        How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

        SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

        What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

        SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

        What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

        SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

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