Recombinant Mouse Trpm4 Protein, Myc/DDK-tagged
Cat.No. : | Trpm4-6677M |
Product Overview : | Purified recombinant protein of mouse full-length transient receptor potential cation channel, subfamily M, member 4 (Trpm4), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells. Plays a role in keratinocyte differentiation. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 136.2 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Trpm4 transient receptor potential cation channel, subfamily M, member 4 [ Mus musculus (house mouse) ] |
Official Symbol : | Trpm4 |
Synonyms : | TRPM4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential cation channel subfamily M member 4; long transient receptor potential channel 4; calcium-activated non-selective cation channel 1; transient receptor potential ion channel melastatin subgroup member 4; LTRPC4; TRPM4B; LTrpC-4; AW047689; 1110030C19Rik; FLJ20041 |
Gene ID : | 68667 |
mRNA Refseq : | NM_175130 |
Protein Refseq : | NP_780339 |
UniProt ID : | Q7TN37 |
Products Types
◆ Recombinant Protein | ||
TRPM4-2264H | Recombinant Human TRPM4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TRPM4-5958R | Recombinant Rat TRPM4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TRPM4-9656M | Recombinant Mouse TRPM4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Trpm4-490M | Recombinant Mouse Trpm4 Protein, His-tagged | +Inquiry |
Trpm4-491R | Recombinant Rat Trpm4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TRPM4-738HCL | Recombinant Human TRPM4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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