Recombinant Mouse Trpm4 Protein, Myc/DDK-tagged

• Cat.No.: Trpm4-6677M
• Product Overview: Purified recombinant protein of mouse full-length transient receptor potential cation channel, subfamily M, member 4 (Trpm4), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells. Plays a role in keratinocyte differentiation.
• Molecular Mass: 136.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Trpm4 transient receptor potential cation channel, subfamily M, member 4 [ Mus musculus (house mouse) ]
• Official Symbol: Trpm4
• Synonyms: TRPM4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential cation channel subfamily M member 4; long transient receptor potential channel 4; calcium-activated non-selective cation channel 1; transient receptor potential ion channel melastatin subgroup member 4; LTRPC4; TRPM4B; LTrpC-4; AW047689; 1110030C19Rik; FLJ20041
• Gene ID: 68667
• mRNA Refseq: NM_175130
• Protein Refseq: NP_780339
• UniProt ID: Q7TN37