| Description : |
Interleukin-4 (IL-4), also known as BSF-1 and Lymphocyte stimulatory factor 1, is a secreted cytokine belonging to the IL-4/IL-13 family. It is produced by mast cells, T cells and bone marrow stromal cells. IL-4 signals through two receptor complexes: theIL4Rα/common γ chain and the IL4Rα-IL-13 Rα1 receptor complex. IL-4 regulates T cell and B cell proliferation, survival and gene expression. IL-4 also induces IgG and IgE class switching, and the upregulation of MHC-II production. |
| Source : |
CHO |
| Species : |
Rat |
| Tag : |
His |
| Form : |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : |
ED50 < 0.2 μg/mL, measured in a proliferationassay using C6 cells. |
| Molecular Mass : |
18-22 kDa, observed by reducing SDS-PAGE. |
| AA Sequence : |
HGCNDSPLREIINTLNQVTEKGTPC TEMFVPDVLTATRNTTENELICRAS RVLRKFYFPRDVPPCLKNKSGVLGE LRKLCRGVSGLNSLRSCTVNESTLT TLKDFLESLKSILRGKYLQSCTSMS HHHHHH |
| Endotoxin : |
< 0.2 EU/μg, determined by LAL method. |
| Purity : |
> 95% as analyzed by SDS-PAGE. |
| Storage : |
Lyophilized recombinant rat Interleukin-4 (IL-4), Hisremains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rat Interleukin-4 (IL-4), Hisshould be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
| Storage Buffer : |
Lyophilized after extensive dialysis against PBS. |
| Reconstitution : |
Reconstituted in ddH2O or PBS at 100 μg/mL. |
