Recombinant Rat Txnrd1 Protein

Cat.No. : Txnrd1-021R
Product Overview : Recombinant Rat Txnrd1 protein(1021-1323) without tag was expressed in E.coli
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Description : The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms.
Source : E. coli
Species : Rat
Unit Definition : One ampoule contains 100 µl of recombinant rat thioredoxin reductase 1 (TrxR1) in 50 mM Tris-HCl, 1 mM EDTA, pH 7.5 and 50 percent glycerol with a total activity of 5 units and 0.15 mg of active enzyme protein. One unit of enzyme catalyses oxidation of one micromol of NADPH per min under standard mammalian TrxR assay conditions in the presence of 5 mM DTNB.
Stability : ≥ 6 months
Storage : -20 centigrade
Shipping : Room Temperature in continental US, may vary elsewhere.
Gene Name : Txnrd1 thioredoxin reductase 1 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Txnrd1
Synonyms : Txnrd1; thioredoxin reductase 1; Tr; thioredoxin reductase 1, cytoplasmic; NADPH-dependent thioredoxin reductase; selenoprotein oxidoreductase; thioredoxin reductase TR1; EC
Gene ID : 58819
mRNA Refseq : NM_001351981
Protein Refseq : NP_001338910

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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