Recombinant Mouse Thioredoxin Reductase 1, His-tagged

Cat.No. : Txnrd1-736M
Product Overview : Recombinant mouse cytosolic thioredoxin with a 6-His tag is fully active with thioredoxin reductase. Mr is approximately 12,000 D.
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Cat. No. : Txnrd1-736M
Description : This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3" UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
Source : E.coli.
Purity : Purified via immunoaffinity column chromatography, it contains no E. coli Thioredoxin-S2.
Presentation : 100 μg of protein, salt-free, lyophilized from 0.5% NH4CO3.
Reconstitution : Add 100 μL of filtered deionized water or physiological buffer to generate a 1 mg/mL solution.
Storage : Store the lyophilized product at 2°- 8°C.
Gene Name : Txnrd1 thioredoxin reductase 1 [ Mus musculus ]
Synonyms : Txnrd1; thioredoxin reductase 1; TR; TR1; TrxR1; thioredoxin reductase 1, cytoplasmic; TR alpha; thioredoxin reductase TR1; EC
Gene ID : 50493
mRNA Refseq : NM_001042513
Protein Refseq : NP_001035978
UniProt ID : Q9JMH6
Chromosome Location : 10 C1; 10
Pathway : Pyrimidine metabolism
Function : FAD binding; NADP or NADPH binding; oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor; thioredoxin-disulfide reductase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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