Coagulation Cascade Protease Inhibitors
About Coagulation Cascade Protease Inhibitors
Coagulation cascade protease inhibitors are a group of proteins that regulate the coagulation process by inhibiting specific proteases involved in blood clot formation. They play a critical role in maintaining the delicate balance between clot formation and prevention of excessive clotting, ensuring proper hemostasis.
The coagulation cascade is a series of enzymatic reactions that involve the activation and conversion of various coagulation factors to ultimately form a stable blood clot. However, uncontrolled or excessive activation of these clotting factors can lead to pathological clotting, which can result in thrombotic disorders such as deep vein thrombosis or stroke.
Coagulation cascade protease inhibitors act at different points within the coagulation pathway to prevent excessive clot formation. Here are some important examples:
- Antithrombin III (ATIII): Antithrombin III is a potent inhibitor of several coagulation factors, including thrombin (Factor IIa) and Factors IXa, Xa, XIa, and XIIa. It works by binding to these proteases and inactivating their enzymatic activity. ATIII is particularly effective in inhibiting thrombin, a key enzyme involved in the conversion of fibrinogen to fibrin.
- Protein C: Protein C is a vitamin K-dependent protein that, when activated, acts as an anticoagulant. Activated Protein C (APC) inhibits Factors Va and VIIIa, which are necessary for the amplification of the coagulation process. By inactivating these factors, Protein C limits the formation of thrombin and subsequent clotting.
- Tissue Factor Pathway Inhibitor (TFPI): TFPI is a protein that inhibits the extrinsic pathway of coagulation. It forms a complex with tissue factor (TF) and Factor VIIa, preventing the initiation of the coagulation cascade. TFPI acts as a natural regulator to prevent excessive clot formation.
- Alpha-2-Macroglobulin (α2M): Alpha-2-macroglobulin is a large plasma protein that inhibits a wide range of proteases, including various coagulation factors. It functions by undergoing a conformational change upon protease binding, trapping and sequestering the protease within its structure, rendering it inactive.
These coagulation cascade protease inhibitors work in conjunction with other regulatory mechanisms to maintain the balance between clot formation and prevention of excessive clotting. They help prevent uncontrolled activation of coagulation factors, ensuring that clot formation occurs only at the site of injury and is appropriately controlled.
Available Resources for Coagulation Cascade Protease Inhibitors
- Creative BioMart offers a wide range of products related to coagulation cascade protease inhibitors, such as recombinant proteins, cell and tissue lysates, and protein pre-coupled magnetic beads.
- Whether you are a researcher in academia or the biopharmaceutical industry, we can provide customized services tailored to your specific requirements.
- In addition to our products and services, we offer a wealth of resources for your reference. These resources cover various aspects of coagulation cascade protease inhibitors, including pathways, protein function, interacting proteins, articles, research areas, and other relevant topics. They are designed to help you deepen your understanding and facilitate the application of coagulation cascade protease inhibitors-related knowledge.
At Creative BioMart, we are committed to supporting your research and development needs in the field of coagulation cascade protease inhibitors. Feel free to explore our products, take advantage of our customized services, and make use of our extensive resources to advance your scientific endeavors.
Our Featured Products
Active Recombinant Human A2M protein, His-tagged
Recombinant Human A2ML1 protein, GST-tagged
Recombinant Mouse Kng1, His tagged
Active Recombinant Human TFPI protein, His-tagged
Recombinant Human TFPI protein, His-tagged, Biotinylated
Recombinant Human TFPI2, His tagged
If you have any questions, requirements, or cooperation intentions, please feel free to contact us. We very much look forward to working with you and helping you achieve research and commercial success.
Reference:
- Schreuder H, Matter H. Serine Proteinases from the Blood Coagulation Cascade[M]. 2020.
