tfpi
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  • Official Full Name
  • Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
  • Background
  • Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 Nm. This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
  • Synonyms
  • TFPI; EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor
Cat.#:TFPI-876HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TFPI Protein, His-tagged, Biotinylated
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Cat.#:TFPI-707HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TFPI Protein, MYC/DDK-tagged
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Cat.#:TFPI-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFPI protein, His-tagged
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Cat.#:TFPI-106HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFPI protein, His/GST-tagged
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Cat.#:TFPI-107HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFPI protein, His/GST-tagged
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Cat.#:TFPI-2333HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TFPI, His-tagged
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Cat.#:TFPI-875HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TFPI protein, His-tagged
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Cat.#:Tfpi-574MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tfpi Protein, His-tagged
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Cat.#:Tfpi-874MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tfpi, His tagged
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Cat.#:Tfpi-981MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Tfpi Protein, His-tagged
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Cat.#:Tfpi-575RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tfpi Protein, His-tagged
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Cat.#:TFPI-4683RTag:His
Source (Host):HEK293Species:Rhesus macaque
Product nameRecombinant Rhesus macaque TFPI protein, His-tagged
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Cat.#:TFPI-576RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit TFPI Protein, His/GST-tagged
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Cat.#:TFPI-2746HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TFPI cell lysate
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Cat.#:TFPI-2843MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TFPI cell lysate
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Involved Pathway

Tfpi involved in several pathways and played different roles in them. We selected most pathways Tfpi participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tfpi were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
BDKRB2; Hc; CD59A; TFPI; CPB2; F5; C8B; SERPINA5; BDKRB1; C3AR1

Protein Function

Tfpi has several biochemical functions, for example, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tfpi itself. We selected most functions Tfpi had, and list some proteins which have the same functions with Tfpi. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase inhibitor activity
Related Protein PROS1; C3A.6; ITIH2; STFA2; Serpina1b; PI3; SPINK1; PSMF1; C3A.3; A2ML
Function serine-type endopeptidase inhibitor activity
Related Protein SPINLW1; SERPINB1B; A1i3; TFPIA; MUG1; SERPINB2; SPINK12; RECK; WFDC6A; SERPINB6

Interacting Protein

Tfpi has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tfpi here. Most of them are supplied by our site. Hope this information will be useful for your research of Tfpi.
ssrna_ug

Tfpi Related Articles

Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
Franchini, M; et al. Next-generation treatment of acquired hemophilia A. EXPERT OPINION ON ORPHAN DRUGS 3:245-251(2015).