ADAM8
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Official Full Name
ADAM metallopeptidase domain 8 -
Overview
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009] -
Synonyms
ADAM8;ADAM metallopeptidase domain 8;MS2;CD156;CD156a;disintegrin and metalloproteinase domain-containing protein 8;cell surface antigen MS2;human leukocyte differentiation antigen;a disintegrin and metalloproteinase domain 8
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Cynomolgus
- Mammalian Cells
- HEK293
- Human Cells
- E.coli
- Insect Cells
- His
- Fc
- T7
- Non
- Avi
- GST
Involved Pathway
ADAM8 involved in several pathways and played different roles in them. We selected most pathways ADAM8 participated on our site, such as Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | MMP12,ADAMTS3,CMA1,CRTAP,ELANE,TIMP2,LTBP3,MFAP1B,ABHD1,FBN2 |
| Degradation of the extracellular matrix | CMA1,TPSAB1,ACAN,MMP17,BMP1A,COL17A1,ADAMTS18,MMP24,COL9A3,FAM49BA |
Protein Function
ADAM8 has several biochemical functions, for example, calcium ion binding,cell adhesion molecule binding,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM8 itself. We selected most functions ADAM8 had, and list some proteins which have the same functions with ADAM8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | ECE2,ADAM30,MIPEP,ADAM10B,ADAMTS15,ASTL,ADAM7,ADAM23,MMP23B,NPSN |
| metallopeptidase activity | C6AST1,TMEM27,ADAM2,PSMD14,MMP23B,AFG3L2,BRCC3,NPSN,Npepo,AQPEP |
| protein binding | HELLS,BTF3,TRIM26,CCDC153,GPN1,IKZF3,MMS22L,RGS6,MXI1,C4orf33 |
| protein self-association | ZSWIM2,PCSK9,MALT1,DVL2,CBR2,LDB1,CCL5,SYP,NKX3-1,MDH2 |
| cell adhesion molecule binding | PVRL3,CXADR,ITGAL,Fert2,PVRL1A,NRXN1,PVRL2,JUP,PVRL1B,NLGN4Y |
| calcium ion binding | NKD1,MMP8,SLC25A25B,PCDHA6,PLCD3A,CDH8,ANXA1,FLG,MYL5,CACNA1SA |
| zinc ion binding | POLR2L,KAT7,ESR1,RBM5,RBM20,WBP4,TRIM2,SOD1,MAN2A1,KDM4B |
Interacting Protein
ADAM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM8.
FSTL3;FST
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References
- Romagnoli, M; Mineva, ND; et al. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO MOLECULAR MEDICINE 6:278-294(2014).
- Li, SQ; Zhu, S; et al. Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. JOURNAL OF TOXICOLOGICAL SCIENCES 39:339-351(2014).
