ADAM8 Protein, ADAM metallopeptidase domain 8


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Official Full Name ADAM metallopeptidase domain 8
Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Synonyms ADAM8; ADAM metallopeptidase domain 8; MS2; CD156; CD156a; disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • Fc
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAM8-355H Recombinant Human ADAM8 protein, His-tagged HEK293 His
    Human ADAM8-525H Recombinant Human ADAM Metallopeptidase Domain 8, His-tagged NS0 His
    Human ADAM8-615H Recombinant Human ADAM8 protein, His & T7-tagged E.coli His/T7
    Mouse ADAM8-1305M Recombinant Mouse ADAM8 Protein Mammalian Cell His
    Mouse Adam8-616M Recombinant Mouse Adam8 protein, His-tagged E.coli His
    Cynomolgus Monkey ADAM8-147C Recombinant Cynomolgus ADAM8, His tagged Human Cell Fc
    Cynomolgus Monkey ADAM8-855CCL Recombinant Cynomolgus ADAM8 cell lysate Human Cell N/A

    ADAM8 involved in several pathways and played different roles in them. We selected most pathways ADAM8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix MMP10; CTSL1; CTSK; TLL1; ADAMTS8; CTSL2; COL23A1; ADAMTS5; TIMP2B; ADAM15
    Extracellular matrix organization LRP4; MFAP4; CTSG; MFAP3; TPSAB1; COL28A1; ELANE; LOC100514666; SERPINH1B; LEPREL2

    ADAM8 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM8 itself. We selected most functions ADAM8 had, and list some proteins which have the same functions with ADAM8. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding SPOCK3; EFEMP1; PKD1L3; MMP1A; DGKAA; EFHD2; NCAN; RPH3A; DLK2; NOX5
    cell adhesion molecule binding CD226; CAML; PTBP3; PVRL3B; CADM1A; SMAGP; NLGN3; CADM1B; CADM1; PKP3
    metalloendopeptidase activity HE2; ADAM17A; MEP1B; PAPPAA; ADAMTS18; NRD1B; ADAM5P; PMPCB; MMP2; C6AST4
    metallopeptidase activity ANPEPA; MMP25; MMP14B; PGCP; MMP1A; BMP1; YME1L1; ADAMTS4; PAPPAB; MMP2
    protein binding CLTC; RAB13; DDB2; EIF2AK3; KL; RPL9; C11orf54; EXOC8; MAPRE3; GLI2
    protein self-association MDH2; PABPN1; AGTR1A; PCSK9; CCDC88C; TP53; ZSWIM2; TMEM43; TRIM32; PROSAPIP1
    zinc ion binding RXRG; ABLIM2; RNF17; RNF139; ZKSCAN5; ZNF346; CPA6; RAD18; EHMT2; CAR1

    ADAM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM8.

    FSTL3; FST

    Li, SQ; Zhu, S; et al. Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. JOURNAL OF TOXICOLOGICAL SCIENCES 39:339-351(2014).
    Romagnoli, M; Mineva, ND; et al. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO MOLECULAR MEDICINE 6:278-294(2014).

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