ak2
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  • Official Full Name
  • adenylate kinase 2
  • Background
  • Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the;reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2,;and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is;tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may;play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in;multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
  • Synonyms
  • AK2; adenylate kinase 2; adenylate kinase 2, mitochondrial; ATP-AMP transphosphorylase 2; adenylate kinase isoenzyme 2, mitochondrial; ADK2; AK 2
Cat.#:Ak2-511RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ak2 Protein, His-tagged
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Cat.#:AK2-117HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Adenylate Kinase 2, His-tagged
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Cat.#:AK2-1345HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AK2, His & GST tagged
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Cat.#:AK2-484HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AK2 Protein, GST-tagged
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Cat.#:AK2-9512HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AK2, GST-tagged
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Cat.#:AK2-1463MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AK2 Protein
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Cat.#:Ak2-3184RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Ak2, His-tagged
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Cat.#:AK2-583RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AK2 Protein
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Cat.#:AK2-283RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AK2 Protein, His-tagged
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Cat.#:AK2-11875ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AK2
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Cat.#:AK2-508HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AK2 cell lysate
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Involved Pathway

AK2 involved in several pathways and played different roles in them. We selected most pathways AK2 participated on our site, such as Purine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PFAS; GUK1B; ADKB; NME7; ENTPD1; NT5C2; PRIM2; AK8; ENTPD2A.1; RRM2
Metabolic pathways
ATP5G3B; SI; NDUFB5; ST3GAL2; DCTPP1; POLR2I; PTGES3A; ACO1; ATP6V1B2; TKTL2

Protein Function

AK2 has several biochemical functions, for example, ATP binding, adenylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK2 itself. We selected most functions AK2 had, and list some proteins which have the same functions with AK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NLRP10; MYO10; CSF1RA; TK2; UBE2KB; EPHB4A; PAPSS2A; TTLL13; MAP4K1; HCK
Function adenylate kinase activity
Related Protein AK5; AK8; AK4; AK7; AK1; AK2

Interacting Protein

AK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK2.
EIF1B; GH1; EPB41; NME2; MCC; PAK2; IKBKE; ACTR6; TRAF6; ABCC5; ABCC6; topA; VCAM1

AK2 Related Articles

Yan, R; Chen, MX; et al. Glycoprotein lb alpha clustering induces macrophage-mediated platelet clearance in the liver. THROMBOSIS AND HAEMOSTASIS 113:107-117(2015).
Alibardi, L; et al. Ultrastructural immunocytochemistry for the central region of keratin associated-beta-proteins (beta-keratins) shows the epitope is constantly expressed in reptilian epidermis. TISSUE & CELL 45:241-252(2013).

AK2 Related Gene Family

TGF Cytokines