Recombinant Full Length Human AK2 Protein, C-Flag-tagged

• Cat.No.: AK2-302HFL
• Product Overview: Recombinant Full Length Human AK2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 26.3 kDa
• AA Sequence: MAPSVPAAEPEYPKGIRAVLLGPPG AGKGTQAPRLAENFCVCHLATGDML RAMVASGSELGKKLKATMDA GKLVSDEMVVELIEKNLETPLCKNG FLLDGFPRTVRQAEMLDDLMEKRKE KLDSVIEFSIPDSLLIRRIT GRLIHPKSGRSYHEEFNPPKEPMKD DITGEPLIRRSDDNEKALKIRLQAY HTQTTPLIEYYRKRGIHSAI
  DASQTPDVVFASILAAFSKATCKDL VMFITRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Purine metabolism

Gene Information

• Gene Name: AK2 adenylate kinase 2 [ Homo sapiens (human) ]
• Official Symbol: AK2
• Synonyms: ADK2
• Gene ID: 204
• mRNA Refseq: NM_001625.4
• Protein Refseq: NP_001616.1
• MIM: 103020
• UniProt ID: P54819