APLNR
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Official Full Name
APLNR apelin receptor
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Synonyms
APLNR; apelin receptor; AGTRL1, angiotensin II receptor like 1; APJ; APJ (apelin) receptor; APJR; FLJ90771; APJ receptor; HG11 orphan receptor; angiotensin receptor-like 1; G protein-coupled receptor APJ; G-protein coupled receptor APJ; angiotensin II receptor-like 1; G-protein coupled receptor HG11; HG11; AGTRL1; FLJ96609; MGC45246;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- Flag,His
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- APLNR Related Articles
- APLNR Related Research Area
APLNR involved in several pathways and played different roles in them. We selected most pathways APLNR participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with APLNR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | GPBAR1;GPR55;KISS1;ADRa1A;CCK;PYYA;SSTR5;POMCB;GPR55A |
| G alpha (i) signalling events | HEBP1;RGS11;RLN3;GPR55;DRD4;RGS1;CCL35.1;RLN3A;ANXA1B |
| GPCR downstream signaling | PPY;FGD2;GPR55;ADORA2B;OXGR1A.1;TAS2R13;OR4D2;SOUL3;CCR3 |
| GPCR ligand binding | EDN1;OXGR1A.1;GPR65;NPFF;CNR1;ADORA2B;LTB4R;PTHLH;ADRA2B |
| GPCRs, Class A Rhodopsin-like | CCBP2;GPR3;GPR27;GPR17;GPR32;SSTR5;CNR2;CCR9;OPN1LW |
| Neuroactive ligand-receptor interaction | GRM2;RXFP2;TRHRB;GCGR;GABRB1;TRPV1;DRD1A;TAAR4;PRLHR2A |
| Peptide ligand-binding receptors | NTS;PENK;TAC3;CX3CR1;INSL3;KEL;CCL35.2;EDN2;CXCL11.8 |
| Signal Transduction | OXGR1;KIF14;CNR2;RGS10;GUCA1E;LINGO1;RHPN1;GHRH;HEBP1 |
APLNR has several biochemical functions, for example, G-protein coupled receptor activity, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLNR itself. We selected most functions APLNR had, and list some proteins which have the same functions with APLNR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | OR4D6;TAS2R139;CXCR6;TACR3L;TMTOPS2B;GPR26;FZD3;CXCR4A;TAS2R20 |
| receptor activity | NPY2R;CSF2RA;ITGB3A;SV2A;CD200R2;Pla2r1;MED24;UBXN6;MED17 |
APLNR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLNR here. Most of them are supplied by our site. Hope this information will be useful for your research of APLNR.
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- Q&As
- Reviews
Q&As (20)
Ask a questionAt present, there is no specific optimal treatment time, which needs to be determined according to the specific situation and condition of the patient.
At present, there are no clear results of long-lasting efficacy studies, and more long-term clinical observations and studies are needed.
As with all drugs, there are risks and side effects associated with the use of APLNR s, such as allergic reactions and bleeding.
There is no clear way to prevent use, and more research and exploration is needed.
According to studies, APLNR can raise HDL cholesterol levels and lower LDL cholesterol levels, thus affecting lipid levels.
Studies have shown that the recombinant APLNR protein is not immunogenic in most people.
At present, there are no relevant studies to prove whether APLNR is effective in the treatment of children, and more research and exploration are needed.
According to research, APLNR may increase the therapeutic effect by regulating its own repair mechanism.
Treatment effectiveness may vary and needs to be evaluated on a patient basis.
Recombinant APLNR proteins can be expressed in microorganisms such as Escherichia coli using genetic engineering technology, and then extracted and purified by protein purification technology.
Yes, there are currently clinical trials underway to evaluate the safety and efficacy of APLNR.
Current studies have shown that APLNR has a potential role in the treatment of diseases such as heart disease, hepatitis, tumors and kidney disease.
According to research, recombinant APLNR may be more effective in the treatment of the elderly.
The therapeutic effect and targeting mechanism of APLNR is mainly through binding to its receptor APJ and activating related signaling pathways.
There is no specific standard dose, and the dosage is usually determined based on patient conditions and clinical trial results.
At present, there are no specific studies to show whether the long-term use of APLNR is safe and effective, and long-term clinical observation is needed.
According to research, the combination of APLNR and other drugs may produce a more significant effect.
Based on current research and clinical trials, APLNR s are more expensive, and more research and production are needed to reduce costs.
At present, there is no detailed evidence that APLNR can completely replace traditional drug therapy, and more research and exploration are needed.
There is currently no specific method of oral administration, but relevant studies may be explored.
Customer Reviews (4)
Write a reviewAPLNR is stable under various experimental conditions and is ideal for a variety of application scenarios.
Green production process of APLNR has the characteristics of high efficiency and environmental protection, and has set a new benchmark for the industry.
The quantitative accuracy of Western blot is very high, which can accurately determine the content of target protein, indicating that it has high accuracy and low error rate.
Stability of APLNR is very good, and it can be carried out for long periods of experimental operation without worrying about changes and effects of its performance.
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