Recombinant Human APLNR protein
Cat.No. : | APLNR-686H |
Product Overview : | Human APLNR full-length ORF (ABM81770.1) recombinant protein without tag. |
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Description : | This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009] |
Source : | Wheat Germ |
Species : | Human |
Form : | Liquid |
Molecular Mass : | 41.8 kDa |
AA Sequence : | MEEGGDFDNYYGADNQSECEYTDWK SSGALIPAIYMLVFLLGTTGNGLVL WTVFRSSREKRRSADIFIASLAVAD LTFVVTLPLWATYTYRDYDWPFGTF FCKLSSYLIFVNMYASVFCLTGLSF DRYLAIVRPVANARLRLRVSGAVAT AVLWVLAALLAMPVMVLRTTGDLEN TTKVQCYMDYSMVATVSSEWAWEVG LGVSSTTVGFVVPFTIMLTCYFFIA QTIAGHFRKERIEGLRKRRRLLSII VVLVVTFALCWMPYHLVKTLYMLGS LLHWPCDFDLFLMNIFPYCTCISYV NSCLNPFLYAFFDPRFRQACTSMLC CGQSRCAGTSHSSSGEKSASYSSGH SQGPGPNMGKGGEQMHEKSIPYSQE TLVVD |
Applications : | Antibody Production; Functional Study; Compound Screening |
Usage : | Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
Gene Name : | APLNR apelin receptor [ Homo sapiens ] |
Official Symbol : | APLNR |
Synonyms : | APLNR; apelin receptor; AGTRL1, angiotensin II receptor like 1; APJ; APJ (apelin) receptor; APJR; FLJ90771; APJ receptor; HG11 orphan receptor; angiotensin receptor-like 1; G protein-coupled receptor APJ; G-protein coupled receptor APJ; angiotensin II receptor-like 1; G-protein coupled receptor HG11; HG11; AGTRL1; FLJ96609; MGC45246; |
Gene ID : | 187 |
mRNA Refseq : | NM_005161 |
Protein Refseq : | NP_005152 |
MIM : | 600052 |
UniProt ID : | P35414 |
Products Types
◆ Recombinant Protein | ||
APLNR-0967H | Recombinant Human APLNR Protein (M1-R330), Flag, His tagged | +Inquiry |
APLNR-187R | Recombinant Rhesus Macaque APLNR Protein, His (Fc)-Avi-tagged | +Inquiry |
APLNR-356H | Recombinant Human APLNR Protein, His (Fc)-Avi-tagged | +Inquiry |
APLNR-371R | Recombinant Rat APLNR Protein, His (Fc)-Avi-tagged | +Inquiry |
APLNR-715R | Recombinant Rat APLNR Protein | +Inquiry |
◆ Lysates | ||
APLNR-8791HCL | Recombinant Human APLNR 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAt present, there is no specific optimal treatment time, which needs to be determined according to the specific situation and condition of the patient.
At present, there are no clear results of long-lasting efficacy studies, and more long-term clinical observations and studies are needed.
As with all drugs, there are risks and side effects associated with the use of APLNR s, such as allergic reactions and bleeding.
There is no clear way to prevent use, and more research and exploration is needed.
According to studies, APLNR can raise HDL cholesterol levels and lower LDL cholesterol levels, thus affecting lipid levels.
Studies have shown that the recombinant APLNR protein is not immunogenic in most people.
At present, there are no relevant studies to prove whether APLNR is effective in the treatment of children, and more research and exploration are needed.
According to research, APLNR may increase the therapeutic effect by regulating its own repair mechanism.
Treatment effectiveness may vary and needs to be evaluated on a patient basis.
Recombinant APLNR proteins can be expressed in microorganisms such as Escherichia coli using genetic engineering technology, and then extracted and purified by protein purification technology.
Yes, there are currently clinical trials underway to evaluate the safety and efficacy of APLNR.
Current studies have shown that APLNR has a potential role in the treatment of diseases such as heart disease, hepatitis, tumors and kidney disease.
According to research, recombinant APLNR may be more effective in the treatment of the elderly.
The therapeutic effect and targeting mechanism of APLNR is mainly through binding to its receptor APJ and activating related signaling pathways.
There is no specific standard dose, and the dosage is usually determined based on patient conditions and clinical trial results.
At present, there are no specific studies to show whether the long-term use of APLNR is safe and effective, and long-term clinical observation is needed.
According to research, the combination of APLNR and other drugs may produce a more significant effect.
Based on current research and clinical trials, APLNR s are more expensive, and more research and production are needed to reduce costs.
At present, there is no detailed evidence that APLNR can completely replace traditional drug therapy, and more research and exploration are needed.
There is currently no specific method of oral administration, but relevant studies may be explored.
Customer Reviews (4)
Write a reviewAPLNR is stable under various experimental conditions and is ideal for a variety of application scenarios.
Green production process of APLNR has the characteristics of high efficiency and environmental protection, and has set a new benchmark for the industry.
The quantitative accuracy of Western blot is very high, which can accurately determine the content of target protein, indicating that it has high accuracy and low error rate.
Stability of APLNR is very good, and it can be carried out for long periods of experimental operation without worrying about changes and effects of its performance.
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