APOB

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APOB

Official Full Name apolipoprotein B
Background This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
Synonyms APOB; apolipoprotein B; FLDB; LDLCQ4; apolipoprotein B-100; apoB-48; apoB-100; apo B-100; mutant Apo B 100; apolipoprotein B48; apolipoprotein B (including Ag(x) antigen);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • Human Plasma
    • Human Tissue
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APOB-1813H Recombinant Human APOB Protein (28-127 aa), His-tagged Yeast His
    Human APOB-128H Recombinant Human APOB protein, GST-tagged Wheat Germ GST
    Human APOB-1H Native Human Apolipoprotein B Human Tissue N/A
    Human APOB-26875TH Native Human APOB N/A
    Human APOB-27149TH Recombinant Human APOB, His-tagged E.coli His
    Human ApoB-3556H Native Human ApoB Human plasma N/A
    Human APOB-613H Native Human Apolipoprotein B (including Ag(x) antigen) Human Plasma N/A
    Human APOB-8037H Native Human Plasma APOB Human Plasma N/A
    Mouse APOB-1784M Recombinant Mouse APOB Protein Mammalian Cell His
    Mouse Apob-493M Recombinant Mouse Apob protein, His-tagged E.coli His
    Rat Apob-2096R Recombinant Rat Apob protein, His & T7-tagged E.coli His/T7
    Chicken APOB-3425C Recombinant Chicken APOB Mammalian Cell His
    Pig APOB-2095P Recombinant Pig APOB protein, His & GST-tagged E.coli His/GST

    APOB involved in several pathways and played different roles in them. We selected most pathways APOB participated on our site, such as Fat digestion and absorption, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fat digestion and absorption AGPAT1; MOGAT2; PPAP2C; DGAT2; PPAP2A; ABCA1; APOA1; PPAP2B; APOB; MOGAT3
    Vitamin digestion and absorption MMACHC; APOA4; SLC19A1; SLC19A3; FOLH1; APOB; ABCC1; SLC5A6; APOA1; SLC19A2

    APOB has several biochemical functions, for example, cholesterol transporter activity, heparin binding, lipase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOB itself. We selected most functions APOB had, and list some proteins which have the same functions with APOB. You can find most of the proteins on our site.

    Function Related Protein
    cholesterol transporter activity CETP; APOA1A; APOE; APOA4B.1; ABCG4B; APOA4; ABCA1; ABCA7; ABCA1B; APOEB
    heparin binding CCL5; CFH; FGF2; CHRD; FN1; SERPINE2; CCL23; BSPH1; LIPH; SELL
    lipase binding FAF2; LRPAP1; APOB; APOA5; PLIN5; GPIHBP1
    low-density lipoprotein particle receptor binding AP2M1; PCSK9; APOEA; LDLRAP1; SYT1; HSP90B1; APOA5; CCDC167; LRPAP1; APOB
    phospholipid binding DGKA; PTAFR; NBEAA; Defa4; PICALMA; APOC3; OSBPL1A; PLA2G2A; F10; SMURF1
    protein binding RSL24D1; RAB33B; ERBB2; KXD1; MLH1; ARHGEF15; IL12B; PTEN; XAGE3; GAS2L3

    APOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOB here. Most of them are supplied by our site. Hope this information will be useful for your research of APOB.

    LDLR; p29991-pro_0000037946; p27958-pro_0000037576; YBX1; p29991-pro_0000037941; AKT2; SMAD3; BNLF1; BNRF1; PRDX4; ARFGAP1; q99ib8-pro_0000045592; q9wmx2-pro_0000037550; midostaurin; RAD21

    Brautbar, A; Leary, E; et al. Genetics of Familial Hypercholesterolemia. CURRENT ATHEROSCLEROSIS REPORTS 17:-(2015).
    Verhoeven, V; Van der Auwera, A; et al. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15:-(2015).

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