areg
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  • Official Full Name
  • amphiregulin
  • Background
  • The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
  • Synonyms
  • AREG; amphiregulin; schwannoma derived growth factor , SDGF; AR; Colorectum cell derived growth factor; CRDGF; A REG; MGC13647; Schwannoma derived growth factor; SDGF; OTTHUMP00000160473; OTTHUMP00000219184; schwannoma-derived growth factor; colorectum cell-derived growth factor; AREGB
Cat.#:AREG-516HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AREG protein, His & GST-tagged
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Cat.#:AREG-529HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human AREG protein
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Cat.#:AREG-7291HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AREG, None tagged
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Cat.#:AREG-743HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AREG protein, GST-tagged
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Cat.#:AREG-918HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AREG Protein, GST-His-tagged
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Cat.#:Areg-32MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Areg protein
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Cat.#:Areg-3433RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Areg, His-tagged
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Cat.#:Areg-517RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Areg protein, His & T7-tagged
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Cat.#:AREG-746RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AREG Protein
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Cat.#:AREG-515CTag:His|GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle AREG protein, His & GST-tagged
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Cat.#:AREG-134HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Amphiregulin
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Cat.#:AREG-8762HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AREG 293 Cell Lysate
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Involved Pathway

AREG involved in several pathways and played different roles in them. We selected most pathways AREG participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with AREG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Asparagine N-linked glycosylation
MPDU1A; MGAT4A; MPDU1; OS9; TRAPPC10; ST6GALNAC1.2; NSFA; TRAPPC9; DERL2; SEC23IP
COPII (Coat Protein 2) Mediated Vesicle Transport
TFG; LMAN2; NAPAA; SEC23IP; CNIH3; AREG; PPP6R1; TRAPPC6B; TRAPPC9; TRAPPC3
Cargo concentration in the ER
CTSC; CNIH2; CNIH; LMAN2; TMED2; MCFD2; SEC23A; CTAGE5; LMAN2L; AREG
ER to Golgi Anterograde Transport
NAPAA; YKT6; USO1; CNIH; TRAPPC2; ANKRD28; PPP6R1; SEC22C; TRAPPC5; SEC24A
ErbB receptor signaling network
AREG
ErbB signaling pathway
NCK2A; HBEGFA; PAK4; PRKCBB; MAPK8; EGFRA; MAP2K2A; AREG; ARAF; MAP2K4
FSH signaling pathway
AREG; CGA; CYP19A1
Hippo signaling pathway
DLG1; SMAD7; NKD1; PARD6A; FZD3; BMP8B; STK3; CTNNA3; CDH1; TCF7L2

Protein Function

AREG has several biochemical functions, for example, cytokine activity, epidermal growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AREG itself. We selected most functions AREG had, and list some proteins which have the same functions with AREG. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GPI; GDF7; IFNA3; BMP3; INHBAB; GPR19; CCL38A.5; Ifnl2; FAM3D; SECTM1
Function epidermal growth factor receptor binding
Related Protein RNF126; CBLC; SNX1; HBEGFB; SNX4; HBEGF; VAV2; TNK2; EFEMP1; ATXN2
Function growth factor activity
Related Protein FGF16; AREG; REG1A; CECR1A; PDGFD; F2; NDP; CLCF1; FGF10A; FGF13B
Function protein binding
Related Protein CHAC1; PTPN23; TGFB3; SECISBP2; OXA1L; VIP; HGF; DEFB121; SRRT; CHAF1A

Interacting Protein

AREG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AREG here. Most of them are supplied by our site. Hope this information will be useful for your research of AREG.
S100A4; S100A2; S100A5; CCND3; ptsA; UBQLN4

AREG Related Articles

Razis, E; Pentheroudakis, G; et al. EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 140:737-748(2014).
Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).