arnt
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  • Official Full Name
  • aryl hydrocarbon receptor nuclear translocator
  • Background
  • The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
Cat.#:ARNT-18HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ARNT, MYC/DDK-tagged
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Cat.#:ARNT-19HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ARNT, MYC/DDK-tagged
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Cat.#:ARNT-20HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ARNT, GST-tagged
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Cat.#:ARNT-288HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ARNT protein, GST-tagged
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Cat.#:ARNT-32HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARNT protein, His/S-tagged
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Cat.#:ARNT-33HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ARNT protein, His-tagged
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Cat.#:ARNT-3648HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ARNT, His-tagged
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Cat.#:ARNT-8057HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARNT protein, His & T7-tagged
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Cat.#:ARNT-1961MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARNT Protein
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Cat.#:Arnt-3647MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Arnt, His-tagged
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Cat.#:ARNT-794RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ARNT Protein
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Cat.#:ARNT-5774CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ARNT
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Cat.#:ARNT-1863ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARNT
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Cat.#:ARNT-8692HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARNT 293 Cell Lysate
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Involved Pathway

ARNT involved in several pathways and played different roles in them. We selected most pathways ARNT participated on our site, such as HIF- signaling pathway, Pathways in cancer, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
HIF- signaling pathway
PRKCB; EGLN1; NOX1; ANGPT2; PIK3R1; ARNT; CAMK2B; CUL2; AKT1; MAPK3
Pathways in cancer
WNT2B; BRCA2; FH; RASSF1; CCNE2; EGLN1; BAX; MMP1A; TFG; GLI2
Chemical carcinogenesis
MGST3; GSTP1; ADH1C; UGT1A6; UGT2B15; AKR1C2; SULT1A1; CYP2C37; GSTA5; CYP2C55
Renal cell carcinoma
SLC2A1; PIK3CG; HIF1A; GRB2; RAPGEF1; PDGFB; PIK3CB; PIK3R2; KRAS; RAC1

Protein Function

ARNT has several biochemical functions, for example, aryl hydrocarbon receptor activity, aryl hydrocarbon receptor binding, enhancer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNT itself. We selected most functions ARNT had, and list some proteins which have the same functions with ARNT. You can find most of the proteins on our site.
Function
Related Protein
Function aryl hydrocarbon receptor activity
Related Protein AHR2; ARNT
Function aryl hydrocarbon receptor binding
Related Protein AIP; ARNT; ARNT2; ARNTL
Function enhancer binding
Related Protein AHR; RAI1; ELL3; TCF12; TIPARP; FOXH1; MESP1; SP1; SMAD2; SMAD3
Function protein binding
Related Protein TYROBP; MLL1; DUSP26; PITX1; EIF3H; ERAP1; CAMKK1; CCHCR1; ACO1; FHL1
Function protein heterodimerization activity
Related Protein HNF1B; ADRA2A; JAM3; IRAK3; HIST1H2AG; RRAGA; H2-AB1; ITGB1A; DMBX1; INHBA
Function contributes_to sequence-specific DNA binding
Related Protein HNRNPAB; TCF3; SMAD4; TRIM28; EPAS1; ARNT; NEUROD1; HIF1A; PPARG; FIGLA
Function transcription coactivator activity
Related Protein TADA2A; JUN; HAND1; HSF2; PIAS1; RFXAP; TAF7L; RAN; SNW1; TAF10
Function contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein ARNT; HIF1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein POU5F2; HOXD10; THRA; RXRA; PCGF2; ZNF157; FOXQ2; ZKSCAN4; ZNF302; SPZ1
Function transcription factor binding
Related Protein PURB; JUNBB; SRY; SP1; KAT2A; KAT8; ATG7; FOXF2; CEBPG; DAXX

Interacting Protein

ARNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNT here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNT.
HIF1A; AHR; NCOA7; NCOR2; Clock; SMAD9

ARNT Related Articles

Basham, KJ; Leonard, CJ; et al. Dioxin Exposure Blocks Lactation through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor. TOXICOLOGICAL SCIENCES 143:36-45(2015).
Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).