Arsa
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Official Full Name
arylsulfatase A
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Overview
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010] -
Synonyms
ARSA; arylsulfatase A; MLD; ASA; cerebroside-sulfatase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Arsa Related Articles
- Arsa Related Research Area
Arsa involved in several pathways and played different roles in them. We selected most pathways Arsa participated on our site, such as Sphingolipid metabolism, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Arsa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | COL4A3BP;CERS2;GALC;ACER3;UGT8;FA2H;SERINC1;GLA;CERK |
| Lysosome | CTSA;HYAL1;NAPSA;AP3S1;CTPS1B;PPT2;GBA;AP1G2;GLB1 |
Arsa has several biochemical functions, for example, arylsulfatase activity, calcium ion binding, cerebroside-sulfatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Arsa itself. We selected most functions Arsa had, and list some proteins which have the same functions with Arsa. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylsulfatase activity | SULF1;ARSG;ARSB;ARSF;ARSD;ARSJ;ARSH;ARSA;ARSE |
| calcium ion binding | F9B;ANXA1B;TBC1D8B;CETN3;CRB2B;DNER;HPCA;EHD3;PCDH10 |
| cerebroside-sulfatase activity | |
| protein binding | KRT83;RIPK3;HEMK1;SMYD2;NOS1AP;TMEM8B;MAPK10;JUB;USP34 |
| sulfuric ester hydrolase activity | STS;GNSB;ARSA;SGSH;SULF2B;GNS;SULF2A;GALNS;GNSA |
Arsa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Arsa here. Most of them are supplied by our site. Hope this information will be useful for your research of Arsa.
TRIP13; TFAP2A; CETN2; PPIC; CLEC4G; xylB
- Q&As
- Reviews
Q&As (4)
Ask a questionYes, several genetic variations, including point mutations, deletions, and insertions, have been identified in the ARSA gene. These variations can lead to reduced ARSA activity and are responsible for different types and severities of metachromatic leukodystrophy.
At present, there is no cure for metachromatic leukodystrophy caused by ARSA deficiency. However, there are some treatments available that aim to manage the symptoms and slow disease progression, such as enzyme replacement therapy and hematopoietic stem cell transplantation. Research is ongoing to develop more effective therapeutic strategies for this condition.
Deficiency of ARSA activity results in the accumulation of sulfatides within cells, particularly in the central and peripheral nervous systems. This buildup leads to the destruction of myelin, impairing nerve signal transmission and causing the symptoms associated with metachromatic leukodystrophy (MLD), such as motor and cognitive deterioration.
Yes, in addition to MLD, alterations in ARSA activity have been implicated in certain types of multiple sclerosis (MS). Although the exact relationship is not fully understood, it is believed that decreased ARSA function may contribute to the pathogenesis of certain forms of MS.
Customer Reviews (3)
Write a reviewBy utilizing the ARSA protein, I can approach my research with unwavering confidence in its quality, along with the unparalleled support provided by its manufacturer.
I am genuinely excited to embark on this scientific journey, empowered by the superior ARSA protein and the manufacturer's unwavering commitment to ensuring my success.
The ARSA protein comes highly recommended due to its exceptional performance in ELISA assays.
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