Recombinant Human ARSA Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ARSA-1274H
• Product Overview: ARSA MS Standard C13 and N15-labeled recombinant protein (NP_001078894) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 53.81 kDa
• AA Sequence: MSMGAPRSLLLALAAGLAVARPPNI VLIFADDLGYGDLGCYGHPSSTTPN LDQLAAGGLRFTDFYVPVSLCTPSR AALLTGRLPVRMGMYPGVLVPSSRG GLPLEEVTVAEVLAARGYLTGMAGK WHLGVGPEGAFLPPHQGFHRFLGIP YSHDQGPCQNLTCFPPATPCDGGCD QGLVPIPLLANLSVEAQPPWLPGLE ARYMAFAHDLMADAQRQDRPFFLYY ASHHTHYPQFSGQSFAERSGRGPFG DSLMELDAAVGTLMTAIGDLGLLEE TLVIFTADNGPETMRMSRGGCSGLL RCGKGTTYEGGVREPALAFWPGHIA PGVTHELASSLDLLPTLAALAGAPL PNVTLDGFDLSPLLLGTGKSPRQSL FFYPSYPDEVRGVFAVRTGKYKAHF FTQGSAHSDTTADPACHASSSLTAH EPPLLYDLSKDPGENYNLLGGVAGA TPEVLQALKQLQLLKAQLDAAVTFG PSQVARGEDPALQICCHPGCTPRPA CCHCPDPHATRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ARSA arylsulfatase A [ Homo sapiens (human) ]
• Official Symbol: ARSA
• Synonyms: ARSA; arylsulfatase A; metachromatic leucodystrophy; ASA; cerebroside-sulfatase; MLD
• Gene ID: 410
• mRNA Refseq: NM_001085425
• Protein Refseq: NP_001078894
• MIM: 607574
• UniProt ID: P15289