ATXN3 Protein, ataxin 3

ATXN3

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ATXN3

Official Full Name ataxin 3
Background Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms ATXN3; ataxin 3; Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) , MJD, SCA3; ataxin-3; ATX3; JOS; josephin; ataxin 3 variant h; ataxin 3 variant m; ataxin 3 variant ref; olivopontocerebellar
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • GST
    • His
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Atxn3-478M Recombinant Mouse Atxn3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ATXN3-1032H Recombinant Human ATXN3 protein, GST-tagged Wheat Germ GST
    Human ATXN3-173H Recombinant Human ATXN3, GST-tagged E.coli GST
    Human ATXN3-27045TH Recombinant Human ATXN3 E.coli N/A
    Human ATXN3-3036H Recombinant Human ATXN3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ATXN3-478H Recombinant Human Ataxin 3 E.coli N/A
    Human ATXN3-52HCL Recombinant Human ATXN3 lysate HEK293 N/A
    Human ATXN3-739H Recombinant Human ATXN3 Protein, DDK-tagged Sf9 Insect Cell DDK
    Rat Atxn3-3689R Recombinant Rat Atxn3, His-tagged E.Coli or Yeast His
    Rat ATXN3-902R Recombinant Rat ATXN3 Protein Mammalian Cell His
    Chicken ATXN3-5928C Recombinant Chicken ATXN3 Mammalian Cell His
    Zebrafish ATXN3-11326Z Recombinant Zebrafish ATXN3 Mammalian Cell His

    ATXN3 involved in several pathways and played different roles in them. We selected most pathways ATXN3 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum UBE2D1A; MOGS; CAPN1; SAR1B; HSPBP1; EDEM3; DNAJC3; HSP26; HSPA1B; RAD23AA

    ATXN3 has several biochemical functions, for example, ATPase binding, Lys48-specific deubiquitinase activity, Lys63-specific deubiquitinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN3 itself. We selected most functions ATXN3 had, and list some proteins which have the same functions with ATXN3. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding ATPIF1A; ATP1B2; ATP1B3; ANK1; S100A1; SVIP; DNAJC10; ALDOB; PTPN3; DRD1A
    Lys48-specific deubiquitinase activity YOD1; ATXN3; OTUD7B
    Lys63-specific deubiquitinase activity YOD1; CYLD; ATXN3
    identical protein binding ALS2CL; STIM1; CHMP4A; CREBZF; BCHE; RYR2; HAND1; AIRE; GBP1; GYPA
    omega peptidase activity UCHL1; JOSD2; ATXN3; GGH; JOSD1; APEH; USP13; ATXN3L; USP5; UCHL5
    protein binding ARL6IP5; RAD54L; IL12A; C12orf5; FAM167A; CHRM3; PCBP1; PRKRIP1; RELB; LIMK2
    ubiquitin protein ligase binding RNF40; SUMO2; YWHAE; CASP10; TRIOBP; HERC2; TRIM28; TRIB1; MAP1LC3B; OTUB1
    ubiquitin-specific protease activity USP44; USP5; USP50; STAMBP; USP12A; USP20; USP1; USP17L5; USP2; USP47

    ATXN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN3.

    VCP; UBC; RAD23B

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