Recombinant Human ATXN3 Protein (E2-K361), Tag Free
Cat.No. : | ATXN3-0367H |
Product Overview : | Recombinant Human GG-ATXN3(E2-K361 end) Protein was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription. Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1. |
Source : | E. coli |
Species : | Human |
Tag : | No tag |
Form : | Liquid |
Protein Length : | E2-K361 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | ATXN3 ataxin 3 [ Homo sapiens (human) ] |
Official Symbol : | ATXN3 |
Synonyms : | ATXN3; ataxin 3; Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3), MJD, SCA3; ataxin-3; ATX3; JOS; josephin; ataxin 3 variant h; ataxin 3 variant m; ataxin 3 variant ref; olivopontocerebellar ataxia 3; Machado-Joseph disease protein 1; spinocerebellar ataxia type 3 protein; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3); AT3; MJD; MJD1; SCA3; |
Gene ID : | 4287 |
mRNA Refseq : | NM_001127696 |
Protein Refseq : | NP_001121168 |
MIM : | 607047 |
UniProt ID : | P54252 |
Products Types
◆ Recombinant Protein | ||
ATXN3-3036H | Recombinant Human ATXN3 Protein, MYC/DDK-tagged | +Inquiry |
Atxn3-478M | Recombinant Mouse Atxn3 Protein, MYC/DDK-tagged | +Inquiry |
ATXN3-558R | Recombinant Rat ATXN3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ATXN3-2786H | Recombinant Human ATXN3 protein(11-290 aa), C-His-tagged | +Inquiry |
ATXN3-0368H | Recombinant Human ATXN3 Protein (E2-K361), His tagged | +Inquiry |
◆ Lysates | ||
ATXN3-52HCL | Recombinant Human ATXN3 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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