Recombinant Rat ATXN3 Protein
Cat.No. : | ATXN3-902R |
Product Overview : | Recombinant Rat ATXN3 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Rat |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Atxn3 ataxin 3 [ Rattus norvegicus ] |
Official Symbol : | ATXN3 |
Gene ID : | 60331 |
mRNA Refseq : | NM_021702.1 |
Protein Refseq : | NP_067734.1 |
MIM : | |
UniProt ID : | O35815 |
Products Types
◆ Recombinant Protein | ||
ATXN3-0367H | Recombinant Human ATXN3 Protein (E2-K361), Tag Free | +Inquiry |
ATXN3-0368H | Recombinant Human ATXN3 Protein (E2-K361), His tagged | +Inquiry |
ATXN3-3036H | Recombinant Human ATXN3 Protein, MYC/DDK-tagged | +Inquiry |
ATXN3-2786H | Recombinant Human ATXN3 protein(11-290 aa), C-His-tagged | +Inquiry |
ATXN3-558R | Recombinant Rat ATXN3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ATXN3-52HCL | Recombinant Human ATXN3 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThe clinical manifestations of SCA3 include ataxia (especially limb motor coordination disorder), myoclonus, ocular muscle movement abnormalities, extrapyramidal symptoms, dysphagia, language disorder, etc. As the disease progresses, patients have more and more significant difficulties with walking, balance, and other movements.
ATXN3 protein is involved in many important cellular processes, including protein degradation, cell signaling, apoptosis, RNA metabolism, etc. It plays an important role in the regulation of cellular functions.
At present, there is no cure for SCA3, but some adjuvant therapies can be used to improve symptoms. Physical therapy, speech therapy and swallowing function training can improve the quality of life of patients. In addition, there are some studies on protein degradation pathways for abnormal aggregation of ATXN3 protein, but they are still in the experimental stage.
In addition to its association with SCA3, ATXN3 protein may also be associated with some other diseases. For example, studies have shown that ATXN3 protein is related to the occurrence and development of neurodegenerative diseases such as Parkinson's disease and Huntington's disease, but the specific mechanism needs to be further studied and verified.
SCA3 is caused by mutations in the ATXN3 gene that lead to excessive repeat of polyglutamine (PolyQ) sequences in ATXN3 protein. This abnormal expansion will cause abnormal ATXN3 protein folding and aggregation, leading to impaired cell function and eventually triggering SCA3 symptoms.
ATXN3 protein is associated with autodominant genetic disease Spinocerebellar Ataxia Type 3 (SCA3). SCA3 is a neurodegenerative disease characterized by ataxia, extrapyramidal symptoms, and motor neuron dysfunction.
Customer Reviews (3)
Write a reviewATXN3 is very catalytic active and shows excellent catalytic performance even at low concentrations.
ATXN3 detection method is sensitive and can detect trace amounts of protein, which is well suited for our study.
Using ATXN3, the reproducibility of my experiments is very good, which facilitates subsequent data analysis and experimental manipulation.
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