ARHGDIB
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Official Full Name
Rho GDP dissociation inhibitor (GDI) beta -
Overview
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM;179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization,;and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly;regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine;nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the;rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed 8356058)). -
Synonyms
ARHGDIB;Rho GDP dissociation inhibitor (GDI) beta;GDIA2, GDID4, RAP1GN1;rho GDP-dissociation inhibitor 2;Ly GDI;RhoGDI2;Rho GDI 2;rho-GDI beta;D4;GDIA2;GDID4;LYGDI;Ly-GDI;RAP1GN1
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Non
- GST
- His
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
ARHGDIB involved in several pathways and played different roles in them. We selected most pathways ARHGDIB participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGDIB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | NRAS,SOS1,SHC1,PIK3R1,MAPK1,RPS6KA2,SHC2,RPS6KA3,MAP2K5,PLCG1 |
Protein Function
ARHGDIB has several biochemical functions, for example, GTPase activator activity,GTPase activity,Rho GDP-dissociation inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGDIB itself. We selected most functions ARHGDIB had, and list some proteins which have the same functions with ARHGDIB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho GDP-dissociation inhibitor activity | ARHGDIA,ARHGDIG |
| GTPase activator activity | SRGAP3,RGS9A,DEPDC1,RALGAPA1,STXBP5A,TBC1D26,RGS17,WNT11,ARFGAP1,RGS5A |
| GTPase activity | RRAS2,ATL3,RAB39B,RRAGC,TUBB2,GNAO1,GNL1,RAB12,GEM,RAB24 |
Interacting Protein
ARHGDIB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGDIB here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGDIB.
RAC2;RAC3;UFM1;RAC1;ANKRD1;dacD;pepP;nagA;asd;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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