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Recombinant Human ARHGDIB protein, GST-tagged

Cat.No. : ARHGDIB-775H
Product Overview : Human ARHGDIB full-length ORF ( AAH09200, 1 a.a. - 201 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 47.85 kDa
AA Sequence : MTEKAPEPHVEEDDDDELDSKLNYK PPPQKSLKELQEMDKDDESLIKYKK TLLGDGPVVTDPKAPNVVVTRLTLV CESAPGPITMDLTGDLEALKKETIV LKEGSEYRVKIHFKVNRDIVSGLKY VQHTYRTGVKVDKATFMVGSYGPRP EEYEFLTPVEEAPKGMLARGTYHNK SFFTDDDKQDHLSWEWNLSIKKEWT E
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARHGDIB Rho GDP dissociation inhibitor (GDI) beta [ Homo sapiens ]
Official Symbol : ARHGDIB
Synonyms : ARHGDIB; Rho GDP dissociation inhibitor (GDI) beta; GDIA2, GDID4, RAP1GN1; rho GDP-dissociation inhibitor 2; Ly GDI; RhoGDI2; Rho GDI 2; rho-GDI beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1;
Gene ID : 397
mRNA Refseq : NM_001175
Protein Refseq : NP_001166
MIM : 602843
UniProt ID : P52566

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Does ARHGDIB have any isoforms or splice variants? 03/03/2023

ARHGDIB does not have known isoforms or splice variants. It is a single gene that encodes a conserved protein across different species and tissues.

How does ARHGDIB regulate Rho GTPases? 12/30/2022

ARHGDIB binds to GTP-bound Rho GTPases and inhibits their activity by preventing their dissociation from the cell membrane, thus keeping them inactive.

Can mutations in the ARHGDIB gene lead to any genetic disorders? 10/02/2022

Mutations in the ARHGDIB gene have not been clearly associated with any genetic disorders. However, further research is needed to explore any potential disease-causing mutations in ARHGDIB.

Does ARHGDIB have any other biological functions? 06/05/2022

Yes, ARHGDIB has been reported to play a role in other cellular processes, including vesicular trafficking, cell adhesion, and apoptosis.

Can changes in ARHGDIB expression be used as a diagnostic marker? 01/07/2022

The potential diagnostic utility of ARHGDIB expression changes is currently not well established. However, alterations in ARHGDIB expression levels have been observed in certain cancers, suggesting its potential as a diagnostic marker in those specific contexts.

What are the similarities and differences between ARHGDIA and ARHGDIB? 08/20/2021

Both ARHGDIA and ARHGDIB are members of the Rho GTPase regulator family and play roles in modulating Rho GTPase activity. However, they have distinct amino acid sequences and may have different tissue expression patterns and specific functions in cellular processes.

Can ARHGDIB interact with other proteins involved in cell signaling pathways? 02/07/2021

Yes, ARHGDIB can interact with various proteins involved in cell signaling pathways, particularly those associated with Rho GTPase signaling. These include guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and effector proteins that mediate downstream signaling events.

How does ARHGDIB affect cell motility? 10/27/2020

ARHGDIB inhibits Rho GTPases, which are central regulators of cell motility. By keeping Rho GTPases inactive, ARHGDIB can suppress cell migration and invasion.

Does ARHGDIB have any known post-translational modifications? 07/29/2020

Yes, ARHGDIB can undergo post-translational modifications such as phosphorylation, acetylation, and ubiquitination, which can regulate its stability, function, and cellular localization.

Are there any known diseases or conditions associated with dysregulation of ARHGDIB? 03/24/2020

Although not extensively studied, some studies have suggested a potential link between ARHGDIB dysregulation and certain diseases, including cancer, neuronal disorders, and cardiovascular diseases. However, more research is needed to establish these associations conclusively.

Are there any known diseases associated with ARHGDIB? 12/10/2019

Although ARHGDIB has not been extensively studied in the context of diseases, alterations in its expression or function have been implicated in certain cancers, such as hepatocellular carcinoma and colorectal cancer.

Are there any knockout studies done on ARHGDIB? 09/26/2019

Yes, knockout studies have been performed on ARHGDIB in animal models to investigate its physiological functions. These studies have provided insights into the role of ARHGDIB in various cellular processes and its impact on overall organismal development.

Does ARHGDIB play a role in any other cellular processes besides cell motility? 07/19/2019

Yes, ARHGDIB has been implicated in various cellular processes, including cell adhesion, cytoskeleton organization, cell polarity, cell division, and vesicle trafficking.

Could modulation of ARHGDIB expression or activity have therapeutic implications in cancer treatment? 05/06/2019

Modulation of ARHGDIB expression or activity may have therapeutic implications in cancer treatment. Since Rho GTPase signaling is involved in cancer progression and metastasis, targeting ARHGDIB might help inhibit these processes and improve treatment outcomes.

Can ARHGDIB be used as a therapeutic target? 01/30/2019

The potential of ARHGDIB as a therapeutic target is still being explored. Modulation of ARHGDIB expression or activity could have therapeutic implications in certain diseases, particularly those involving aberrant Rho GTPase signaling. However, further studies are needed to assess the feasibility and efficacy of targeting ARHGDIB for therapeutic interventions.

Is there any ongoing research focused on ARHGDIB? 12/22/2018

Yes, ongoing research is focused on further understanding the role of ARHGDIB in cellular processes, its potential involvement in diseases, and its therapeutic implications. Researchers are also exploring the underlying molecular mechanisms of ARHGDIB regulation and its interactions with other proteins.

Is there any research on the therapeutic potential of targeting ARHGDIB? 09/22/2017

As of now, there is limited research on targeting ARHGDIB for therapeutic purposes. However, further investigations are needed to explore its potential as a therapeutic target in various diseases.

Are there any known binding partners of ARHGDIB? 03/20/2017

ARHGDIB has been reported to interact with several proteins, including Rho GTPases, specific guanine nucleotide exchange factors (GEFs), and other regulatory proteins involved in Rho GTPase signaling.

Customer Reviews (8)

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Reviews
12/23/2022

    a manufacturer that offers reliable and high-quality ARHGDIB protein can significantly enhance the research experience.

    06/18/2021

      With their commitment to delivering high-quality products, I am confident in achieving successful outcomes and advancing my research.

      11/10/2020

        By using ARHGDIB protein, I can gain insights into the underlying molecular processes contributing to amyloidosis, which can ultimately aid in the development of novel therapeutic strategies.

        09/16/2019

          Such a manufacturer can provide technical expertise and guidance throughout the experimental process, from experimental design to troubleshooting and data analysis.

          11/04/2018

            In addition to the advantages of ARHGDIB protein, collaborating with a manufacturer that offers exceptional support can greatly benefit researchers.

            09/30/2017

              The manufacturer plays a crucial role in supporting my research with their extensive expertise and resources.

              05/06/2017

                This assurance enables me to confidently utilize the ARHGDIB protein in my research, knowing that it will consistently deliver reliable and accurate results.

                03/14/2016

                  the manufacturer facilitates access to the latest scientific advancements and developments related to ARHGDIB protein research.

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