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BACE1

  • Official Full Name

    beta-site APP-cleaving enzyme 1

  • Overview

    Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
  • Synonyms

    BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • human|IgG1|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BACE1-253H Active Recombinant Human BACE1 protein(Met1-Thr457), hFc-tagged HEK293 C-hFc Met1-Thr457
Human BACE1-27426TH Recombinant Human BACE1, FLAG-tagged Flag
Human BACE1-26297TH Recombinant Human BACE1 E.coli N/A
Human BACE1-891H Recombinant Human BACE1 protein, His-tagged HEK293 His Thr22-Thr457
Human BACE1-219H Recombinant Human BACE1, C13&N15-labeled HEK293 N/A
Human BACE1-1661H Recombinant Human Beta-Site APP-Cleaving Enzyme 1 E.coli N/A
Human BACE1-102H Recombinant Human BACE1, GST-tagged Wheat Germ GST
Human BACE1-713H Recombinant Human BACE1 protein, His & GST-tagged E.coli His/GST Phe170~Thr428 (Accession# P56817)
Human BACE1-255H Active Recombinant Human BACE1 protein HEK293 N/A Met1-Thr457
Human BACE1-003H Recombinant Human BACE1 protein HEK293 Thr22-Thr457
Human BACE1-31H Recombinant Human Beta-Site APP-Cleaving Enzyme 1 E.coli N/A
Human BACE1-002H Recombinant Human BACE1 protein, Fc-tagged HEK293 human/IgG1/Fc Thr22-Thr457
Human BACE1-3006HCL Recombinant Human BACE1 cell lysate Human Cell N/A
Human BACE1-2200H Recombinant Human BACE1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human BACE1-0398H Recombinant Human BACE1 protein, His-tagged E.coli His 157-457 aa
Human BACE1-779H Recombinant Human BACE1 Protein HEK293 501
Human BACE1-2682H Recombinant Human BACE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BACE1-780H Recombinant Human BACE1 Protein, Fc-tagged HEK293 Fc 501
Human BACE129323H Recombinant Human BACE1 (22-446) (R56T, R57T) Protein, His-tagged E.coli His
Human BACE1-781H Recombinant Human BACE1 Protein HEK293 501
Human BACE1-2685H Recombinant Human BACE1 protein, His-tagged HEK293 His Thr22-Tyr460
Human BACE1-0360H Recombinant Human BACE1 Protein (Glu46-Thr457), N-His-tagged E.coli N-His Glu46-Thr457
Human BACE1-2938H Active Recombinant Human BACE1 protein HEK293 N/A Thr 22-Thr 457
Human BACE1-2939H Recombinant Human BACE1 protein, Fc-tagged HEK293 Fc Thr 22-Thr 457
Human BACE1-2940H Active Recombinant Human BACE1 protein, His-tagged HEK293 His Thr 22-Thr 457
Mouse Bace1-714M Recombinant Mouse Bace1 protein, His & GST-tagged E.coli His/GST Pro190~Ala430 (Accession # P56818)
Mouse Bace1-252M Active Recombinant Mouse Bace1 protein(Met1-Thr457), His-tagged HEK293 C-His Met1-Thr457
Mouse BACE1-3077MCL Recombinant Mouse BACE1 cell lysate Human Cell N/A
Mouse Bace1-1815M Recombinant Mouse Bace1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat BACE1-929R Recombinant Rat BACE1 Protein Mammalian Cell His
Rat Bace1-715R Recombinant Rat Bace1 protein, His-tagged E.coli His Gly181~Tyr366 (Accession # P56819)
Rat BACE1-587R Recombinant Rat BACE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BACE1-587R-B Recombinant Rat BACE1 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL3660HF Recombinant Full Length Human Beta-Secretase 1(Bace1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (46-501)
Mus musculus (Mouse) RFL25174MF Recombinant Full Length Mouse Beta-Secretase 1(Bace1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (46-501)
Rattus norvegicus (Rat) RFL27958RF Recombinant Full Length Rat Beta-Secretase 1(Bace1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (46-501)
Rhesus Macaque BACE1-503R Recombinant Rhesus monkey BACE1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BACE1-331R-B Recombinant Rhesus Macaque BACE1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BACE1-331R Recombinant Rhesus Macaque BACE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish BACE1-11726Z Recombinant Zebrafish BACE1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BACE1 Related Articles
  • BACE1 Related Research Area

BACE1 involved in several pathways and played different roles in them. We selected most pathways BACE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with BACE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseBACE1;COX7A2L;COX6A2;ATP2A2;UQCRQ;NDUFA3;NDUFV3;ATP5G1;FADD

BACE1 has several biochemical functions, for example, aspartic-type endopeptidase activity, beta-amyloid binding, beta-aspartyl-peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BACE1 itself. We selected most functions BACE1 had, and list some proteins which have the same functions with BACE1. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activitySPPL2;NRIP3;PGA;NOTS;Ren1;NRIP2;ASPRV1;DDI1;REN2
beta-amyloid bindingBCHE;TSSK1B;CHRNA7;APBA2;LDLRAD3;BACE1;Apba1;MAPK8IP2;GPRASP2
beta-aspartyl-peptidase activity
enzyme bindingRFC5;HSPA6;HNRNPUL1;RARA;MAT2B;CSF3;MARCH6;BCL10;CYP3A4
peptidase activityTMPRSS13A;F2RL1.1;C1rb;ZRANB1B;PRSS48;LTA4H;DPEP3;CTSG;DHH
protein bindingKCNK16;MCM3;THRAA;HLX;SMAGP;GGACT;PREP;ERP27;LRRK1

BACE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BACE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BACE1.

Clec4g; FLOT2; APP; Flot1; FLOT1; MMP2; CSNK1D; App

Sadleir, KR; Eimer, WA; et al. A beta reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Molecular Neurodegeneration 10:-(2015).
Yu, YJ; Atwal, JK; et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any potential side effects associated with BACE1 inhibition? 08/20/2021

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

How is BACE1 linked to Alzheimer's disease? 01/05/2020

BACE1 is implicated in Alzheimer's disease as it initiates the cleavage of APP, leading to the formation of beta-amyloid plaques, a hallmark of the disease.

How can BACE1 inhibitors potentially benefit Alzheimer's patients? 08/11/2018

BACE1 inhibitors may slow down or prevent the accumulation of beta-amyloid plaques, potentially delaying the progression of Alzheimer's disease.

Are there any ongoing clinical trials involving BACE1 inhibitors? 09/22/2017

Yes, several clinical trials are underway to assess the safety and efficacy of BACE1 inhibitors in treating Alzheimer's disease.

Are there clinical applications of BACE1 inhibitors? 08/07/2016

Yes, BACE1 inhibitors are being explored as potential therapeutic agents for Alzheimer's disease to reduce the production of beta-amyloid peptides.

Customer Reviews (3)

Write a review
Reviews
07/27/2020

    Such support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of BACE1 protein.

    12/23/2019

      A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.

      09/30/2019

        Using BACE1 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.

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