bax
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  • Official Full Name
  • BCL2-associated X protein
  • Background
  • This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms
  • BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296
Cat.#:BAX-6976HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, His-tagged
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Cat.#:Bax-1381MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein, GST-tagged
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Cat.#:Bax-244MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein
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Cat.#:BAX-094HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-095HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-26650THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX protein, GST-tagged
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Cat.#:BAX-458HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BAX
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Cat.#:BAX-6975HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, GST-tagged
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Cat.#:BAX-2300MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAX Protein
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Cat.#:BAX-514RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAX Protein, His-tagged
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Cat.#:BAX-321HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Associated X Protein, GST-tagged
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Cat.#:BAX-8506HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAX 293 Cell Lysate
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Involved Pathway

Bax involved in several pathways and played different roles in them. We selected most pathways Bax participated on our site, such as Sphingolipid signaling pathway, p signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bax were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid signaling pathway
SPTLC2; SGPL1; PIK3CA; RAC2; ASAH1; SMPD2; PIK3CB; CERS5; PRKCA; RAF1
p signaling pathway
GADD45BA; STEAP3; RRM2B; SESN1; SESN2; BAI1; GADD45AB; TSC2; FAS; ATM
Protein processing in endoplasmic reticulum
DAD1; NSFL1C; UBXN6; MOGS; LMAN1; UBE2J2; TRAM1; DNAJA1; HSPA1B; MAP3K5
Apoptosis
PRKAR1A; DIABLOB; PKP1; PRKAR2AB; TNFRSF10A; DBNL; PIK3R5; PIK3CD; BCL2L1; IRF6
Neurotrophin signaling pathway
GRB2; MAP3K1; CALM4; CDC42; RELA; RHOA; HRAS; NFKBIA; MAGED1; PIK3CD
Non-alcoholic fatty liver disease (NAFLD)
ERN1; TNF; TGFB1; FAS; IL-8; UQCRC2; PIK3CA; NDUFA11; IL1B; CASP8
Amyotrophic lateral sclerosis (ALS)
BAD; BID; PPP3CB; TNFRSF1B; MAPK11; DAXX; MAP2K3; TOMM40; NOS1; GRIN2D
Huntingtons disease
DNALI1; SLC25A4; TGM2; HTT; POLR2C; NDUFC2; NDUFA11; DNAH11; DNALC1; POLR2G
Prion diseases
C1QB; BAX; C1QA; IL6; STIP1; NCAM1; C8B; CASP12; IL1A; MAP2K1
Tuberculosis
IFNA14; TLR9; RFXAP; PMAP-36; MAPK10; KSR1; RIPK2; APAF1; IFNB1; PLK3
Hepatitis B
MAPK8; FASLG; NFKBIA; NFATC3; MAPK10; APAF1; TICAM2; VDAC3; HRAS; IL-8
HTLV-I infection
FZD2; WNT11; TGFB1; ANAPC5; TBPL2; CDC20; DVL2; SLC25A4; IL15RA; CCND2
Pathways in cancer
BCL2L1; RAF1; MITF; FLT3LG; RARA; MAP2K1; MAPK10; FGF17; CCNA1; LAMC2
Viral carcinogenesis
YWHAZ; POLB; HLA-B; NFKB1; PMAIP1; HLA-G; RBL1; SRC; CCNE1; TRAF1
Colorectal cancer
PIK3CD; AKT2; MAPK10; AXIN1; RHOA; FOS; RAC1; LEF1; PIK3R3; AKT1

Protein Function

Bax has several biochemical functions, for example, BH3 domain binding, channel activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bax itself. We selected most functions Bax had, and list some proteins which have the same functions with Bax. You can find most of the proteins on our site.
Function
Related Protein
Function BH3 domain binding
Related Protein BAX; MCL1; BCL2L1; BCL2
Function channel activity
Related Protein BAXA; TRPA1; BAXB; P2RX6; GJA8; PANX2; CHRNB1; PANX1A; PANX1B; STEAP1
Function chaperone binding
Related Protein HSPA5; TRP53; CLU; HYOU1; DNAJA2; STIP1; BAG5; PFDN6; DNAJC10; DNAJB5
Function heat shock protein binding
Related Protein PPP5C; BAK1; DNAJA4; DNAJA3B; HSPA9; IRAK1; SSUH2.2; HDAC2; NFKBIA; DNAJA3
Function identical protein binding
Related Protein CBX3; STAT6; PDCD6; GSTM3; MRAP2; DIAP1; TNPO3; TTN; HOOK3; AKT1
Function lipid binding
Related Protein SEC14L3; ALOX15B; ANXA6; PACSIN1B; ACBD6; APOC2; Fert2; TRIP10; APOA4A; ESYT3
Function protein binding
Related Protein MSRB3; NR1H4; DAK; PCID2; STX19; TUBA4A; PARP1; FAM127C; BTN2A2; ATP7B
Function protein complex binding
Related Protein ATF1; FGFR1; GIT1; TELO2; DRD1A; RIPK1; ULK1; NASP; NCKAP1; UFD1L
Function protein heterodimerization activity
Related Protein TAS1R2; NKX2; HIST1H2AF; ABTB2; HIST1H4H; CASP8; P4HB; HIST4H4; HIST1H2AK; FLOT2
Function protein homodimerization activity
Related Protein XDH; NPR3; BMP7A; MAPK4; BST2; ZFP365; CHUK; DMRT1; PSPH; ZFP652

Bax Related Articles

Beers, K; Ferguson, J; et al. Comparison of the RAPID-B-(R) flow cytometer and the BAX((R)) system for the detection of non-0157 shiga toxin-producing Escherichia coli (STEC) in beef products. FOOD CONTROL 50:72-75(2015).
Gurzu, S; Kadar, Z; et al. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS 123:223-233(2015).

Bax Related Gene Family

BCL2 Gene Family