bax
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  • Official Full Name
  • BCL2-associated X protein
  • Background
  • This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms
  • BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296
Cat.#:BAX-6976HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, His-tagged
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Cat.#:Bax-1381MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein, GST-tagged
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Cat.#:Bax-244MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein
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Cat.#:BAX-8493HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant human BAX protein, GST-tagged
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Cat.#:BAX-094HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-095HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-26650THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX protein, GST-tagged
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Cat.#:BAX-458HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BAX
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Cat.#:BAX-6975HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, GST-tagged
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Cat.#:BAX-2300MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAX Protein
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Cat.#:BAX-514RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAX Protein, His-tagged
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Cat.#:BAX-321HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Associated X Protein, GST-tagged
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Cat.#:BAX-8506HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human BAX 293 Cell Lysate
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Involved Pathway

Bax involved in several pathways and played different roles in them. We selected most pathways Bax participated on our site, such as Sphingolipid signaling pathway, p signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bax were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid signaling pathway
NOS3; KRAS; AKT1; BDKRB2; PPP2R5B; PIK3R5; NSMAF; PLD2; PPP2R2B; PPP2R5D
p signaling pathway
FAS; Casp3; COP1; SERPINE1; RPRM; LRDD; TRP53; RPRMA; SESN2; CCNB2
Protein processing in endoplasmic reticulum
HERPUD1; UBE2E3; NFE2L2A; TUSC3; UBE2D2; CRYAA; CAPN2; HSPA8; PARK2; SEL1L2
Apoptosis
PIK3R3; CAPN1; TNFRSF10B; PRKAR2B; CRADD; TNFRSFA; BNIP3LB; IKBKG; NMT1; PTBP3
Neurotrophin signaling pathway
Fasl; CALML5; RPS6KA6; MAP3K5; NTRK2; CAMK2A; SHC1; CAMK4; CAMK2B; NFKB1
Non-alcoholic fatty liver disease (NAFLD)
IL1B; PIK3CB; NDUFA4L2; ERN1; PIK3R2; NDUFA4; TNFRSF1A; NDUFC2-KCTD14; TNF; ADIPOR1
Amyotrophic lateral sclerosis (ALS)
CASP1; BCL2L1; ALS2; NEFH; GRIA1; PPP3CB; CASP12; TOMM40; BAD; GRIN2B
Huntingtons disease
NDUFB5; IFT57; POLR2J3; DNAL4; REST; DNALI1; NDUFB9; NDUFC2-KCTD14; NDUFB8; POLR2J
Prion diseases
NCAM2; MAPK3; IL6; C8A; CASP12; HSPA1A; C9; NCAM1; CCL5; C1QB
Tuberculosis
Ifna11; CAP18; MAPK9; IFNA6; APAF1; RAB5B; TRAF6; IFNA21; HLA-DRB3; MAPK10
Hepatitis B
RELA; YWHAZ; SRC; MAPK8; CCNE1; BAD; TGFB2; PIK3CA; FAS; OSTN
HTLV-I infection
SMAD3; IL15RA; ATF4; RRAS; CDC20; LTA; TGFB1; TNFRSF13C; IL15; POLD4
Pathways in cancer
BMP2; PAX8; GNG2; BCL2; BIRC7; FGFR3; NKX3-1; CXCL12; MMP1; LAMA5
Viral carcinogenesis
RBL2; TBP; RBL1; HIST1H4E; CDC42; HIST1H2BN; CDC20; HDAC8; VDAC3; RBPJ
Colorectal cancer
MSH2; CYCS; PIK3R2; RAC2; RAF1; BAX; MAPK8; RHOA; PIK3R5; BAD

Protein Function

Bax has several biochemical functions, for example, BH3 domain binding, channel activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bax itself. We selected most functions Bax had, and list some proteins which have the same functions with Bax. You can find most of the proteins on our site.
Function
Related Protein
Function BH3 domain binding
Related Protein BCL2; BCL2L1; BAX; MCL1
Function channel activity
Related Protein PANX2; APNL; GJA8; BAX; MAL; TRPA1; P2RX6; CHRNB1; BCL2; BAXB
Function chaperone binding
Related Protein SERPINA7; DNAJB2; Alb; PFDN6; DNAJA3B; PRNP; BAG5; SYVN1; GNB5; TSACC
Function heat shock protein binding
Related Protein HDAC2; DNAJA3; HSPA1A; PACRG; HSPA8; CDC37; NFKB1; PPP5C; FKBP5; DAXX
Function identical protein binding
Related Protein DRG1; TLR3; KIRRELA; PKD2L1; SUN2; VWA2; CD247; ATF3; C1QTNF2; BCL2L1
Function lipid binding
Related Protein FABP9; BPIFB7; LIPF; BPIFB1; SNX27; MTTP; APOA4B.1; S100A13; CETP; APOL6
Function protein binding
Related Protein EFCAB12; GNB2L1; PDCL3; TCOF1; UQCC2; MAP1B; CNTROB; FRS2; C6orf108; TMSB4Y
Function protein complex binding
Related Protein TRADD; INS2; TAPBPL; C8B; AP2A2; CDKN1B; HADHA; TMED10; NCKAP1L; CD2AP
Function protein heterodimerization activity
Related Protein PIK3R2; TXLNG; NOTCH1; ITGB1A; MYF5; HIST1H4F; ZBTB1; TLR6; MTTP; ZHX2
Function protein homodimerization activity
Related Protein TESC; CSF1R; ASNSD1; TMEM192; DPP4; ZFP652; PDCD6IP; CTBP1; G6PD; CRYBB2

Bax Related Articles

Beers, K; Ferguson, J; et al. Comparison of the RAPID-B-(R) flow cytometer and the BAX((R)) system for the detection of non-0157 shiga toxin-producing Escherichia coli (STEC) in beef products. FOOD CONTROL 50:72-75(2015).
Gurzu, S; Kadar, Z; et al. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS 123:223-233(2015).

Bax Related Gene Family

BCL2 Gene Family