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Bax

  • Official Full Name

    BCL2-associated X protein

  • Overview

    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms

    BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Human
  • Mouse
  • Pig
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Protein Conjugation
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BAX-6976H Recombinant Human BAX, His-tagged E.coli His Met1-Gln171
Human BAX-26650TH Recombinant Human BAX protein, GST-tagged E.coli GST
Human BAX-458H Recombinant Human BAX Mammalian Cell His
Human BAX-321H Recombinant Human BCL2-Associated X Protein, GST-tagged E.coli GST
Human BAX-094H Recombinant Human BAX Protein, GST-tagged Wheat Germ GST
Human BAX-095H Recombinant Human BAX Protein, GST-tagged Wheat Germ GST
Human BAX-6975H Recombinant Human BAX, GST-tagged E.coli GST Full length
Human BAX-8506HCL Recombinant Human BAX 293 Cell Lysate HEK293 N/A
Human BAX-6977H Recombinant Human BAX protein, His-tagged E.coli His Met1~Gln171
Human BAX-31H Recombinant Human BAX Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human BAX-8493H Recombinant human BAX protein, GST-tagged E.coli GST 192
Human BAX-3974H Recombinant Human BAX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human BAX-2780H Recombinant Human BAX Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Pro43-Glu61
Human BAX-1216HFL Recombinant Full Length Human BAX Protein, C-Flag-tagged Mammalian cells Flag
Human BAX-1578HF Recombinant Full Length Human BAX Protein, GST-tagged In Vitro Cell Free System GST 192 amino acids
Human BAX-426H Recombinant Human BAX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BAX-426H-B Recombinant Human BAX Protein Pre-coupled Magnetic Beads HEK293
Human BAX-0221H Recombinant Human BAX Protein (Met1-Gln171), C-His-tagged E.coli C-His Met1-Gln171
Mouse Bax-1381M Recombinant Mouse BCL2-associated X Protein, GST-tagged E.coli GST
Mouse BAX-2300M Recombinant Mouse BAX Protein Mammalian Cell His
Mouse Bax-244M Recombinant Mouse BCL2-associated X Protein E.coli N/A
Mouse BAX-970M Recombinant Mouse BAX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bax-691M Recombinant Mouse Bax Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BAX-970M-B Recombinant Mouse BAX Protein Pre-coupled Magnetic Beads HEK293
Mouse Bax-299M Recombinant Mouse Bax Protein, His-tagged E.coli N-His Met1-Gly192
Bos taurus (Bovine) RFL2475BF Recombinant Full Length Bovine Apoptosis Regulator Bax(Bax) Protein, His-Tagged E.coli expression system His Full Length (1-192)
Rattus norvegicus (Rat) RFL25339RF Recombinant Full Length Rat Apoptosis Regulator Bax(Bax) Protein, His-Tagged E.coli expression system His Full Length (1-192)
Rhesus Macaque BAX-514R Recombinant Rhesus monkey BAX Protein, His-tagged Mammalian Cell His
Rhesus Macaque BAX-342R-B Recombinant Rhesus Macaque BAX Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BAX-342R Recombinant Rhesus Macaque BAX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig BAX-300P Recombinant Pig BAX Protein, His-tagged E.coli N-His Asp2-Gly192
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Bax Related Articles
  • Bax Related Gene Family
  • Bax Related Research Area
  • Bax Related Signal Pathway

Bax involved in several pathways and played different roles in them. We selected most pathways Bax participated on our site, such as Sphingolipid signaling pathway, p signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bax were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid signaling pathwayGNAI1;S1PR5;LASS4;LASS5;PIK3CD;SMPD2;NRAS;ROCK1;PPP2R2C
p signaling pathwayBIDA;COP1;IGFBP3;SIAH1;CCNB2;CASP8;BAI1;IGF1;RRM2B
Protein processing in endoplasmic reticulumDNAJC5GA;SAR1A;CALR;RRBP1;HSPA2;EDEM1;SYVN1;UBE2D2A;HSPH1
ApoptosisCASP6L2;TNFSF10;STK24;PRKAR1B;TP53;XIAP;CASP3A;PRKAR2B;BAD
Neurotrophin signaling pathwayMAP2K2;FASLG;GAB1;ARHGDIG;MAP2K5;BAX;ZFP110;CALML5;CDC42
Non-alcoholic fatty liver disease (NAFLD)NDUFA13;NDUFA10;NDUFB7;IL1B;PIK3CG;IL1A;NDUFS4;NDUFB2;KCNA3
Amyotrophic lateral sclerosis (ALS)TNF;MAPK14;BCL2L1;CASP12;MAPK11;TOMM40L;GRIN1;PPP3CC;TP53
Huntingtons diseaseREST;PLCB1;SLC25A31;NDUFA1;POLR2J2;NDUFA3;NDUFA8;COX6C;POLR2C
Prion diseasesC8B;CCL5;C9;C1QB;BAX;C1QC;PRNP;C5;PRKACA
TuberculosisTLR9;BCL10;FCGR3B;PPP3R2;ATP6V0A2;MAPK1;RAB7A;CARD9;TGFB1
Hepatitis BIFNA1;YWHAZ;NFKB1;DDX58;CCND1;EGR2;IFIH1;OSTN;TLR3
HTLV-I infectionMYBL2;STAT5B;CCND3;WNT9A;PDGFRA;WNT16;BUB1B;EP300;Fzd4
Pathways in cancerTGFA;FGF1;PRKCB;GLI3;WNT5A;Fasl;WNT3A;BRAF;CTBP2
Viral carcinogenesisKAT2B;HDAC7;YWHAG;PMAIP1;HIST1H4N;HIST1H4D;CCNE1;HIST1H4I;HIST1H2BA
Colorectal cancerAPPL1;APC;SMAD2;MAPK1;TCF7;MAPK3;MAPK9;BCL2;RAC1

Bax has several biochemical functions, for example, BH3 domain binding, channel activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bax itself. We selected most functions Bax had, and list some proteins which have the same functions with Bax. You can find most of the proteins on our site.

Function Related Protein
BH3 domain bindingMCL1;BAX;BCL2L1;BCL2
channel activityP2RX6;PANX1B;BAXA;PANX1A;GJA8;MAL;STEAP1;TRPA1;CHRNB1
chaperone bindingBIRC5;C1orf182;DNAJB4;SYVN1;BAK1;PFDN6;SDF2L1;SOD1;DNAJB2
heat shock protein bindingDNAJA3A;BAK1;NFKBIA;PPID;HSPA8;DNAJA3;TFAM;EEF1D;GRXCR2
identical protein bindingPARK7;SOX10;C1S;BNIP3;APPL1;GOT1;SEPHS1;MLL1;SERPINA1
lipid bindingSNX10B;PACSIN1B;SH3GLB1;CYTH1;PSAP;FAM123A;APOA4B.1;PTGS1;RUFY1
protein bindingZNF317;AZGP1;IFIT3;XBP1;IGFLR1;FBP2;CLK3;TXNDC5;C19orf10
protein complex bindingC8A;NFYB;ATP6V1B1;ITPR1;EPCAM;VDAC1;VPS28;MYSM1;PDZK1
protein heterodimerization activityBCL2A1A;ARNT;IKBKB;H3F3A;POLA1;HIST1H2B7;MEF2A;GCLC;NEFH
protein homodimerization activityMBL1;ATIC;HSD17B4;RAB11FIP4B;GRPEL1;NRBP1;HNF4A;S100A1;CADM1A

Bax has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bax here. Most of them are supplied by our site. Hope this information will be useful for your research of Bax.

Beers, K; Ferguson, J; et al. Comparison of the RAPID-B-(R) flow cytometer and the BAX((R)) system for the detection of non-0157 shiga toxin-producing Escherichia coli (STEC) in beef products. FOOD CONTROL 50:72-75(2015).
Gurzu, S; Kadar, Z; et al. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS 123:223-233(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are genetic mutations in BAX linked to any diseases? 06/12/2022

Some genetic mutations in BAX are associated with cancer.

What therapeutic strategies are being explored involving BAX? 04/04/2022

Strategies include modulating BAX activity for cancer therapy and neurodegenerative diseases.

How does BAX interact with other members of the Bcl-2 protein family? 03/24/2022

BAX can form heterodimers with anti-apoptotic Bcl-2 proteins, or homodimers to promote apoptosis.

What happens when BAX is dysregulated? 04/28/2020

Dysregulation can lead to excessive cell death or contribute to cancer.

What is BAX's role in cellular apoptosis? 02/25/2020

BAX promotes apoptosis by permeabilizing the mitochondrial membrane.

What triggers the activation of BAX? 10/29/2019

Stress signals or cellular damage can trigger BAX activation.

How is BAX regulated within the cell? 10/07/2019

It is regulated by various members of the Bcl-2 family and other signaling pathways.

Customer Reviews (3)

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Reviews
01/07/2020

    Reliable partner for protein expression and analysis.

    01/23/2019

      Swift and reliable protein purification services.

      01/18/2018

        Consistency in results, a hallmark of their service.

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