bax
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  • Official Full Name
  • BCL2-associated X protein
  • Background
  • This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
  • Synonyms
  • BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296
Cat.#:BAX-6976HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, His-tagged
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Cat.#:Bax-1381MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein, GST-tagged
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Cat.#:Bax-244MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse BCL2-associated X Protein
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Cat.#:BAX-094HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-095HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BAX Protein, GST-tagged
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Cat.#:BAX-26650THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX protein, GST-tagged
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Cat.#:BAX-458HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BAX
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Cat.#:BAX-6975HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BAX, GST-tagged
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Cat.#:BAX-2300MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BAX Protein
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Cat.#:BAX-514RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BAX Protein, His-tagged
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Cat.#:BAX-321HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL2-Associated X Protein, GST-tagged
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Cat.#:BAX-8506HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BAX 293 Cell Lysate
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Involved Pathway

Bax involved in several pathways and played different roles in them. We selected most pathways Bax participated on our site, such as Sphingolipid signaling pathway, p signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bax were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid signaling pathway
TNF; SPTLC2; RAC1; PTEN; PPP2R5C; PRKCA; BAX; SGPP2; PRKCE; NRAS
p signaling pathway
CASP8; TP53; SIAH1; CCNG2; GADD45BA; CCND2A; THBS1; PTENA; SERPINE1; GTSE1
Protein processing in endoplasmic reticulum
CUL1A; AMFR; RRBP1B; WFS1; HSP90B1; SEC61A1; SEC24C; DNAJC5; VIMP; PKZ
Apoptosis
CASP7; BAXA; FAS; CASP3A; IL1A; FASLG; NFKBIA; IRAK1; TP53; BNIP3L
Neurotrophin signaling pathway
KRAS; MAPK11; BAX; RIPK2; SORT1; CAMK4; NGFR; FOXO3; CAMK2B; MAPK10
Non-alcoholic fatty liver disease (NAFLD)
IL-8; EIF2AK3; ADIPOR2; AKT2; COX7A2L; PIK3R2; NDUFB9; RXRA; NDUFB6; PKLR
Amyotrophic lateral sclerosis (ALS)
TP53; SLC1A2; GRIN2B; CASP12; PRPH; MAPK12; BCL2; MAPK11; APAF1; MAP2K3
Huntingtons disease
CREB3L1; MT-ATP6; UCP1; NDUFV3; POLR2B; HTT; BDNF; NDUFV1; NDUFB3; PLCB2
Prion diseases
PRKACG; C8B; SOD1; C1QB; IL6; NOTCH1; PRNP; LAMC1; NCAM2; LOC100033925
Tuberculosis
TNF; PPP3CC; Casp3; CALM4; MAPK12; IFNA17; ARHGEF12; RAB5C; EP300; CAMK2A
Hepatitis B
STAT1; HRAS; IFNA13; IFNA7; IFNA17; CASP10; IL6; ATP6AP1; MAPK9; Ifna11
HTLV-I infection
TGFB1; PIK3CD; PIK3CG; HRAS; ELK1; HLA-DPB1; PPP3CB; ELK4; FZD2; NFATC3
Pathways in cancer
BCL2L1; CASP9; RAC3; MAP2K2; TGFBR1; FGFR2; CXCR4; WNT7A; GNAI3; WNT4
Viral carcinogenesis
MAD1L1; CCNA2; HIST1H4B; PIK3R1; IRF3; CASP8; HDAC10; HDAC9; MDM2; HIST1H4E
Colorectal cancer
MAPK8; RALGDS; TCF7; DCC; APC; MSH6; CASP9; MAPK3; TP53; Casp3

Protein Function

Bax has several biochemical functions, for example, BH3 domain binding, channel activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bax itself. We selected most functions Bax had, and list some proteins which have the same functions with Bax. You can find most of the proteins on our site.
Function
Related Protein
Function BH3 domain binding
Related Protein BCL2; MCL1; BAX; BCL2L1
Function channel activity
Related Protein STEAP1; BAX; APNL; BCL2; MAL; TRPA1; P2RX6; BAXB; CHRNB1; GJA8
Function chaperone binding
Related Protein PFDN4; CDC37L1; INS1; UBL4; BIRC5; DNAJC10; TBCE; ERP29; USP13; BAK1
Function heat shock protein binding
Related Protein PPP5C; TFAM; DLST; BAX; HSPA8; FAF1; SSUH2.2; DNAJA2L; HSPA6; DMPK
Function identical protein binding
Related Protein MMP9; GUCY2E; ANXA4; C1QTNF9; CXADR; NOL3; CTSC; OAT; TRIP13; MAP1S
Function lipid binding
Related Protein GPIHBP1; CRABP2B; APOA5; ACOT11B; RASGRP1; ATP5G3; YBX2; ALOX8; RBP2A; MTTP
Function protein binding
Related Protein SP2; CARM1; VPS36; HBA2; NF1; KRTAP3-2; PIANP; RPL7A; PTH1R; NHP2
Function protein complex binding
Related Protein UQCRC1; KIF11; PFKP; MYSM1; LAMB3; MAPK8IP2; LRRC16A; TULP2; RRAS; CDK4
Function protein heterodimerization activity
Related Protein UGT1A4; TGFB2; KCNH1; HIST1H2BI; MAPK6; SRI; H3F3B.1; PAFAH1B2; SOX32; CEBPA
Function protein homodimerization activity
Related Protein APOA2; MSH2; MECOM; PVRL3B; UGT1A6B; HPRT1; HNF4A; ERP29; MAP3K12; ENPP1

Bax Related Articles

Beers, K; Ferguson, J; et al. Comparison of the RAPID-B-(R) flow cytometer and the BAX((R)) system for the detection of non-0157 shiga toxin-producing Escherichia coli (STEC) in beef products. FOOD CONTROL 50:72-75(2015).
Gurzu, S; Kadar, Z; et al. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS 123:223-233(2015).

Bax Related Gene Family

BCL2 Gene Family