birc3
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  • Official Full Name
  • baculoviral IAP repeat containing 3
  • Background
  • This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
  • Synonyms
  • BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4
Cat.#:BIRC3-190HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BIRC3, GST-tagged
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Cat.#:BIRC3-27246THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human BIRC3
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Cat.#:BIRC3-554HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human BIRC3
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Cat.#:BIRC3-635HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BIRC3 Protein, GST-tagged, Active
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Cat.#:BIRC3-69HTag:GST/StrepII
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BIRC3 protein, GST/StrepII-tagged
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Cat.#:BIRC3-70HTag:His/Strep II
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human BIRC3 protein, His/StrepII-tagged
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Cat.#:BIRC3-8450HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BIRC3 293 Cell Lysate
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Cat.#:BIRC3-8451HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BIRC3 293 Cell Lysate
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Involved Pathway

BIRC3 involved in several pathways and played different roles in them. We selected most pathways BIRC3 participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
IL1B; BIRC3; ATM; PLAU; LBP; TRAF2; ICAM1; XIAP; CCL21; DDX58
Ubiquitin mediated proteolysis
UBE3A; UBA2; UBE2D1A; UBE2G1B; KEAP1B; PARK2; ITCH; PIAS1; XIAP; UBE2M
Apoptosis
NFKBIAB; TNFRSF1A; ADD1; HDR; CASP6L1; BMX; PRKAR2A; PRKAR1A; NFKBIA; BAXB
Focal adhesion
COL6A3; LAMA3; RHOAB; RAC2; MAPK8B; ZYX; IGF1; RAF1B; CAV3; ROCK2A
NOD-like receptor signaling pathway
NAIP1; MAPK8; HSP90AA1.1; IKBKG; CASP8; NFKBIAB; NFKBIB; BIRC3; TRIP6; MAPK10
TNF signaling pathway
MAP2K3; CXCL3; PTGS2; MAPK11; SOCS3; RIPK1; MAPK1; NFKBIA; ATF4; CCL20
Toxoplasmosis
LAMB4; HLA-DQA2; IFNGR1; IRAK4; LAMA2; Toxoplasma Gondii Major Surface Antigen P30; LAMB2; HLA-DRB3; MAP2K3; TYK2
Pathways in cancer
LPAR2; MMP9; LAMC2; MMP1; GNG11; BAD; HSP90B1; BDKRB1; WNT9A; Fgf15
Transcriptional misregulation in cancer
TP53; MEIS1; REL; BIRC3; PBX1; PRCC; SPINT1; HDAC2; SP1; RUNX2
Small cell lung cancer
TRAF4; PTEN; APAF1; IKBKG; PIK3CB; BIRC2; ITGAV; NFKB1; BIRC8; CCNE2

Protein Function

BIRC3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC3 itself. We selected most functions BIRC3 had, and list some proteins which have the same functions with BIRC3. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein BIRC3; PRDX5; C1QL4L; CD27; LEF1; NAIP1; BIRC2; XIAP; BIRC8; MT3
Function ligase activity
Related Protein RNF181; TRIM56; PCXA; RING1; TRIM27; RAG1; CTPS1A; CBX4; MYLIPA; TRIM41
Function protein binding
Related Protein TACC1; SLC1A2; SCNM1; TRAM2; ZNF69; TAF3; CD200R4; TBC1D17; FUBP3; MASP1
Function ubiquitin-protein transferase activity
Related Protein XIAP; TRIM37; ARIH1; TNFAIP3; RNF11; RNF20; RNF25; UHRF1; MUL1B; TRIM23
Function zinc ion binding
Related Protein ZFYVE19; PHF21A; SIRT5; LIMS2; MNAT1; RABGGTB; SLC30A8; ZDHHC16; YY1; BTR16

Interacting Protein

BIRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC3.
TRAF2; RIPK2; RIPK4; RIPK1; RIPK3; UBA1