- Human(12)
Recombinant Human BIRC3, GST-tagged
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Cat.No. : | BIRC3-190H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant full-length human BIRC3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
Description : | BIRC3 or baculoviral IAP repeat containing 3 is a member of the IAP family of proteins. BIRC3 inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and thereby interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. BIRC3 is a potential oncogene which is overexpressed in multiple lung cancers with or without higher copy numbers. BIRC3 is a key regulator of NOD innate immunity signaling. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~105 kDa |
Purity : | >75% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens ] |
Official Symbol : | BIRC3 |
Synonyms : | BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF49; TNFR2 TRAF signaling complex protein; IAP-1; IAP homolog C; RING finger protein 49; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; AIP1; API2; CIAP2; HAIP1; HIAP1; c-IAP2; |
Gene ID : | 330 |
mRNA Refseq : | NM_001165 |
Protein Refseq : | NP_001156 |
MIM : | 601721 |
UniProt ID : | Q13489 |
Chromosome Location : | 11q22 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem; |
Function : | metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding; |
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◆ Lysates
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