Recombinant Human BIRC3, GST-tagged

Cat.No. : BIRC3-190H
Product Overview : Recombinant full-length human BIRC3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : BIRC3 or baculoviral IAP repeat containing 3 is a member of the IAP family of proteins. BIRC3 inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and thereby interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. BIRC3 is a potential oncogene which is overexpressed in multiple lung cancers with or without higher copy numbers. BIRC3 is a key regulator of NOD innate immunity signaling.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~105 kDa
Purity : >75% by densitometry
Applications : Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens ]
Official Symbol : BIRC3
Synonyms : BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF49; TNFR2 TRAF signaling complex protein; IAP-1; IAP homolog C; RING finger protein 49; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; AIP1; API2; CIAP2; HAIP1; HIAP1; c-IAP2;
Gene ID : 330
mRNA Refseq : NM_001165
Protein Refseq : NP_001156
MIM : 601721
UniProt ID : Q13489
Chromosome Location : 11q22
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem;
Function : metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of BIRC3 in apoptosis regulation? 10/29/2022

BIRC3 (cIAP2) inhibits apoptosis, regulating cell death.

How does BIRC3 interact with other proteins in apoptosis pathways? 08/29/2022

BIRC3 interacts with proteins in apoptosis pathways, influencing cell survival.

What role does BIRC3 play in immune responses? 07/12/2022

BIRC3 plays a role in immune response, especially in inflammation.

How do genetic variations in BIRC3 affect disease susceptibility? 10/24/2020

Genetic changes in BIRC3 affect susceptibility to cancers and immune disorders.

How does BIRC3 contribute to cell survival? 10/12/2019

It promotes cell survival by blocking apoptosis signals.

What is the impact of altered BIRC3 activity on inflammatory conditions? 12/30/2017

Altered BIRC3 activity impacts inflammatory disease progression.

What potential therapeutic applications arise from targeting BIRC3 in inflammatory and cancerous diseases? 07/07/2017

Targeting BIRC3 could treat diseases with abnormal apoptosis, like cancer and inflammation.

Customer Reviews (3)

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11/09/2019

    Key to our research success, a trusted partner.

    06/22/2017

      Dependable partner, integral to research integrity.

      06/12/2017

        Efficient and precise, a research necessity.

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