Recombinant Human BIRC3 293 Cell Lysate

Cat.No. : BIRC3-8451HCL
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Description : Antigen standard for baculoviral IAP repeat-containing 3 (BIRC3), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens ]
Official Symbol : BIRC3
Synonyms : BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF49; TNFR2 TRAF signaling complex protein; IAP-1; IAP homolog C; RING finger protein 49; baculoviral IAP repeat-containing 3; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1; AIP1; API2; CIAP2; HAIP1; HIAP1; c-IAP2;
Gene ID : 330
mRNA Refseq : NM_182962
Protein Refseq : NP_892007
MIM : 601721
UniProt ID : Q13489
Chromosome Location : 11q22
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Ceramide signaling pathway, organism-specific biosystem;
Function : metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of BIRC3 in apoptosis regulation? 10/29/2022

BIRC3 (cIAP2) inhibits apoptosis, regulating cell death.

How does BIRC3 interact with other proteins in apoptosis pathways? 08/29/2022

BIRC3 interacts with proteins in apoptosis pathways, influencing cell survival.

What role does BIRC3 play in immune responses? 07/12/2022

BIRC3 plays a role in immune response, especially in inflammation.

How do genetic variations in BIRC3 affect disease susceptibility? 10/24/2020

Genetic changes in BIRC3 affect susceptibility to cancers and immune disorders.

How does BIRC3 contribute to cell survival? 10/12/2019

It promotes cell survival by blocking apoptosis signals.

What is the impact of altered BIRC3 activity on inflammatory conditions? 12/30/2017

Altered BIRC3 activity impacts inflammatory disease progression.

What potential therapeutic applications arise from targeting BIRC3 in inflammatory and cancerous diseases? 07/07/2017

Targeting BIRC3 could treat diseases with abnormal apoptosis, like cancer and inflammation.

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11/09/2019

    Key to our research success, a trusted partner.

    06/22/2017

      Dependable partner, integral to research integrity.

      06/12/2017

        Efficient and precise, a research necessity.

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