Recombinant Human BIRC3 BIRC3-27246TH

Recombinant Human BIRC3

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Cat.No. : BIRC3-27246TH Optional Service: Optional requirements on this protein
Product Overview : Recombinant full length Human cIAP2 with a proprietary tag; predicted MWt 95.4kDa inclusive of tag.
Description : This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
Protein length : 604 amino acids
Molecular Weight : 95.400kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HClNote: Glutathione is reduced
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS THSLLPGTEN SGYFRGSYSN SPSNPVNSRA NQDFSALMRS SYHCAMNNEN ARLLTFQTWP LTFLSPTDLA KAGFYYIGPG DRVACFACGG KLSNWEPKDN AMSEHLRHFP KCPFIENQLQ DTSRYTVSNL SMQTH
Sequence Similarities : Belongs to the IAP family.Contains 3 BIR repeats.Contains 1 CARD domain.Contains 1 RING-type zinc finger.
Gene Name : BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens ]
Official Symbol : BIRC3
Synonyms : BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4
Gene ID : 330
mRNA Refseq : NM_001165
Protein Refseq : NP_001156
MIM : 601721
Uniprot ID : Q13489
Chromosome Location : 11q22
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem;
Function : metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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