Recombinant Human BIRC3

• Cat.No.: BIRC3-27246TH
• Product Overview: Recombinant full length Human cIAP2 with a proprietary tag; predicted MWt 95.4kDa inclusive of tag.

Specification

• Description: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
• Protein length: 604 amino acids
• Molecular Weight: 95.400kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HClNote: Glutathione is reduced
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MNIVENSIFLSNLMKSANTFELKYD LSCELYRMSTYSTFPAGVPVSERSL ARAGFYYTGVNDKVKCFCCGLMLDN WKRGDSPTEKHKKLYPSCRFVQSLN SVNNLEATSQPTFPSSVTNSTHSLL PGTENSGYFRGSYSNSPSNPVNSRA NQDFSALMRSSYHCAMNNENARLLT FQTWPLTFLSPTDLAKAGFYYIGPG DRVACFACGGKLSNWEPKDNAMSEH LRHFPKCPFIENQLQDTSRYTVSNL SMQTH
• Sequence Similarities: Belongs to the IAP family.Contains 3 BIR repeats.Contains 1 CARD domain.Contains 1 RING-type zinc finger.
• Tag: Non

Gene Information

• Gene Name: BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens ]
• Official Symbol: BIRC3
• Synonyms: BIRC3; baculoviral IAP repeat containing 3; API2, baculoviral IAP repeat containing 3; baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2; c IAP2; cIAP2; hiap 1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RNF4
• Gene ID: 330
• mRNA Refseq: NM_001165
• Protein Refseq: NP_001156
• MIM: 601721
• Uniprot ID: Q13489
• Chromosome Location: 11q22
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem
• Function: metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Reviews

11/09/2019

Key to our research success, a trusted partner.

06/22/2017

Dependable partner, integral to research integrity.

06/12/2017

Efficient and precise, a research necessity.

Q&As

What is the primary role of BIRC3 in apoptosis regulation?

BIRC3 (cIAP2) inhibits apoptosis, regulating cell death.

How does BIRC3 interact with other proteins in apoptosis pathways?

BIRC3 interacts with proteins in apoptosis pathways, influencing cell survival.

What role does BIRC3 play in immune responses?

BIRC3 plays a role in immune response, especially in inflammation.

How do genetic variations in BIRC3 affect disease susceptibility?

Genetic changes in BIRC3 affect susceptibility to cancers and immune disorders.

How does BIRC3 contribute to cell survival?

It promotes cell survival by blocking apoptosis signals.

What is the impact of altered BIRC3 activity on inflammatory conditions?

Altered BIRC3 activity impacts inflammatory disease progression.

What potential therapeutic applications arise from targeting BIRC3 in inflammatory and cancerous diseases?

Targeting BIRC3 could treat diseases with abnormal apoptosis, like cancer and inflammation.