bmp6
Share
  • Official Full Name
  • bone morphogenetic protein 6
  • Background
  • The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
  • Synonyms
  • BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related) , VGR; VGR1; BMP-6; BMP6_HUMAN; Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; HGNC:12686; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VG-1-R; VG-1-related protein; VGR-1; OTTHUMP00000016006; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR
Cat.#:BMP6-162HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human BMP6 Protein, Biotinylated
+Inquiry
Cat.#:BMP6-273HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMP6 Protein, GST-tagged
+Inquiry
Cat.#:BMP6-575HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human bone morphogenetic protein 6, His-tagged
+Inquiry
Cat.#:BMP6-2433MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BMP6 Protein
+Inquiry
Cat.#:Bmp6-28MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Bmp6
+Inquiry
Cat.#:Bmp6-655RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp6 protein, His-tagged
+Inquiry
Cat.#:BMP6-998RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BMP6 Protein
+Inquiry
Cat.#:BMP6-2125ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BMP6
+Inquiry
Cat.#:BMP6-41HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMP6
+Inquiry
Cat.#:BMP6-42HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein 6
+Inquiry
Cat.#:BMP6-68HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human BMP6
+Inquiry
Cat.#:Bmp6-27MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Bone Morphogenetic Protein 6
+Inquiry
Cat.#:BMP6-8430HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BMP6 293 Cell Lysate
+Inquiry

Involved Pathway

BMP6 involved in several pathways and played different roles in them. We selected most pathways BMP6 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
BMPR2B; ACVR1B; BMP8B; INHBC; ZFYVE16; CHD; TGFBR1A; SMAD2; GDF6; BMP6
Hippo signaling pathway
TGFB2; FZD7; PARD3; SMAD4; YAP1; BMP6; BMP5; LATS2; BIRC2; WWTR1
Ovarian steroidogenesis
INS1; HSD17B2; PLA2G4C; BMP6; PRKACB; PLA2G4A; AKR1C3; ALOX5; FSHR; PRKACA

Protein Function

BMP6 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP6 itself. We selected most functions BMP6 had, and list some proteins which have the same functions with BMP6. You can find most of the proteins on our site.
Function
Related Protein
Function BMP receptor binding
Related Protein BMP5; BMP7; BMP8A; PYCARD; BMP7B; BMP4; BMP7A; BMP2; BMP8B; BMP2B
Function cytokine activity
Related Protein MSTN; IL11; IL21; CMTM1; GDF10B; FAM3C; IFNB1; IL17C; IL18; IFNA7
Function growth factor activity
Related Protein TFF1; BMP16; PGF; GFER; FGF6A; AMH; VEGFC; TGFA; PTN; Artn
Function protein heterodimerization activity
Related Protein TCF12; HIST1H2BK; ATF3; ITGA3; RRAGC; CD3G; SOX6; HIST1H4J; MICU1; CRLF1
Function transforming growth factor beta receptor binding
Related Protein BMP7A; LEFTY2; FKBP1A; BMP3; BMP5; GDF6; TGFBR3; BMP8B; AMH; BMP4

BMP6 Related Articles

Eberlein, C; Rooney, C; et al. E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin alpha v beta 6 and maintained through TGF beta signalling. ONCOGENE 34:704-716(2015).
Tang, YH; Li, YY; et al. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25:675-682(2014).

BMP6 Related Gene Family

TGF