bmp7
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  • Official Full Name
  • bone morphogenetic protein 7
  • Background
  • BMP-7, also known as osteogenic protein 1, is a 431 amino acid secreted protein that belongs to the TGF-beta family. It is expressed in the kidney and bladder as well as in the brain at lower levels. During embryogenesis, BMP-7 is detected in the developing eye, brain, and ear. BMP-7 is consisted of a disulfide-linked homodimer and it interacts with SOSTDC1 and TWSG1. Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. BMP-7 is determined to induce cartilage and bone formation. It may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Moreover, BMP-7 is found to play a role in calcium regulation and bone homeostasis. It is available under the name Osigraft (Stryker) and its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.
  • Synonyms
  • RP11-560A15.5, OP-1; osteogenic protein 1; OP-1
Cat.#:BMP2&BMP7-709HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP2&BMP7
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Cat.#:BMP7-105HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMP7
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Cat.#:BMP7-134HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human BMP7
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Cat.#:BMP7-135HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human BMP7 Active
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Cat.#:BMP7-1548HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human BMP7, Active
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Cat.#:BMP7-163HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP7 Protein, Biotinylated
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Cat.#:BMP7-207HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP7 protein, His/S-tagged
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Cat.#:BMP7-26285THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMP7, His-tagged
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Cat.#:BMP7-27031THTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP7
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Cat.#:BMP7-274HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMP7 Protein, GST-tagged
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Cat.#:BMP7-508HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human BMP7, HIgG1 Fc-tagged, mutant
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Cat.#:Bmp7-208MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bmp7 protein, His/S-tagged
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Cat.#:Bmp7-42MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bmp7 protein, His-tagged
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Cat.#:Bmp7-568MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Bmp7 protein, His-tagged
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Cat.#:Bmp7-589MTag:
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Bmp7
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Cat.#:Bmp7-209RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Bmp7 protein, His/S-tagged
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Cat.#:BMP7-03HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein-7
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Cat.#:BMP7-07HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein 7
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Cat.#:BMP7-10HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein 7, His-tagged
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Cat.#:BMP7-8429HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BMP7 293 Cell Lysate
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Cat.#:BMP7-126HGTag:
Source (Host):CHO cellSpecies:Human
Product nameGMP Recombinant Human BMP7 Protein
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Involved Pathway

BMP7 involved in several pathways and played different roles in them. We selected most pathways BMP7 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
KITB; BMPR2A; TNFRSF1B; IL4; CXCL5; CSH; ACVR2A; IL11RA2; TNFB; IL6
TGF-beta signaling pathway
RHOA; BMPR2A; FST; RHOAD; ACVR1C; LEFTY2; NOG3; TGFBR1A; PITX2; RPS6KB2
Hippo signaling pathway
SAV1; GDF5; FZD2; YWHAB; LATS2; WWC1; PARD6A; CCND3; MOBKL1A; CCND1

Protein Function

BMP7 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP7 itself. We selected most functions BMP7 had, and list some proteins which have the same functions with BMP7. You can find most of the proteins on our site.
Function
Related Protein
Function BMP receptor binding
Related Protein BMP4; BMP2B; PYCARD; BMP8A; BMP3; BMP2; BMP7B; BMP7; BMP8B; BMP6
Function cytokine activity
Related Protein IFNA14; BMP10; THPO; GREM2; IL10; SLURP1; Il23a; Il12b; IL37; CSF1; IL13
Function growth factor activity
Related Protein GPI1; GPI; IL10; EREG; FGF18B; NRTN; FBRS; NENF; THPO; CTGF
Function heparin binding
Related Protein RSPO2; WISP1B; LIPG; NOV; BMP4; APPA; COL13A1; COL5A1; PDCD5; FGFRL1
Function protein binding
Related Protein IP6K2; MAP3K1; NAT8; WIPI2; cgr2b; SLC3A1; ZMYND10; INPP5B; RAD51C; FAM104A
Function transforming growth factor beta receptor binding
Related Protein GDF6B; GDF7; INHBC; LRG1; GDF11; SMAD3; SPAW; INHBB; INHBAA; FKBP1A

Interacting Protein

BMP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP7.
Acvr2a; NOG; MTUS2

BMP7 Related Articles

Siddique, I; Curran, SP; et al. Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients. AMERICAN JOURNAL OF PATHOLOGY 184:2976-2984(2014).
Khurana, S; Melacarne, A; et al. SMAD Signaling Regulates CXCL12 Expression in the Bone Marrow Niche, Affecting Homing and Mobilization of Hematopoietic Progenitors. STEM CELLS 32:3012-3022(2014).

BMP7 Related Gene Family

TGF