|Official Full Name||bone morphogenetic protein 7|
|Background||BMP-7, also known as osteogenic protein 1, is a 431 amino acid secreted protein that belongs to the TGF-beta family. It is expressed in the kidney and bladder as well as in the brain at lower levels. During embryogenesis, BMP-7 is detected in the developing eye, brain, and ear. BMP-7 is consisted of a disulfide-linked homodimer and it interacts with SOSTDC1 and TWSG1. Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms. BMP-7 is determined to induce cartilage and bone formation. It may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Moreover, BMP-7 is found to play a role in calcium regulation and bone homeostasis. It is available under the name Osigraft (Stryker) and its use is indicated in the treatment of tibial non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.|
|Synonyms||RP11-560A15.5, OP-1; osteogenic protein 1; OP-1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BMP7 involved in several pathways and played different roles in them. We selected most pathways BMP7 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||PDGFAB; GHRA; GM2506; AMHR2; CCR8L; IL28A; CXCR3.2; BMPR1BA; ACVR1B; IL18R1|
|TGF-beta signaling pathway||ROCK2B; SMAD5; TFDP1A; BAMBIA; SMAD3; ACVR1L; NODAL; PPP2R1A; ACVR1BA; MAPK1|
|Hippo signaling pathway||CDH1; BMP8B; WNT8B; GDF7; ID2; AXIN2; PPP2R2C; CCND3; BMPR2; WNT11|
BMP7 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP7 itself. We selected most functions BMP7 had, and list some proteins which have the same functions with BMP7. You can find most of the proteins on our site.
|BMP receptor binding||BMP7B; BMP3; BMP7; BMP5; BMP7A; BMP2B; BMP8A; BMP4; BMP6; PYCARD|
|cytokine activity||IFNA8; CCL38.1; TXLNA; IFNA13; IL1RN; SCGB3A1; NODAL; WNT2; Il1f8; IFN-a|
|growth factor activity||GFER; FGF11A; FGF2; GH1; INHBE; GDF1; GDF2; BMP6; IGF2; CXCL12|
|heparin binding||COL25A1; CCL23; APLP1; FGF2; FMOD; NAV2; EPYC; GREM2; PF4V1; PTPRF|
|protein binding||C10orf62; BCKDHA; OLR1; INSIG1; NCOA1; PLXDC1; WNT3A; HIST1H4E; TBC1D23; POLG2|
|transforming growth factor beta receptor binding||LFT1; BMP10; GDF2; GDF6B; BMP7A; BMP2B; NODAL; NDR1; BMP7; SMURF2|
BMP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP7.
Acvr2a; NOG; MTUS2