bmpr2
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  • Official Full Name
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • Background
  • BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-beta ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death
  • Synonyms
  • BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase); PPH1, primary pulmonary hypertension 1; bone morphogenetic protein receptor type-2; BMPR II; BMPR3; BRK 3; T ALK; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II ac
Cat.#:BMPR2-2707HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR2 Protein, MYC/DDK-tagged
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Cat.#:BMPR2-10258HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMPR2, His-tagged
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Cat.#:BMPR2-133HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR2, Fc-His tagged
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Cat.#:BMPR2-134HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR2, His tagged
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Cat.#:BMPR2-287HTag:GST
Source (Host):Sf21 cellsSpecies:Human
Product nameRecombinant Human BMPR2 Protein, GST-tagged
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Cat.#:BMPR2-288HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BMPR2 Protein, GST-tagged
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Cat.#:BMPR2-556HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human BMPR2, Fc-tagged, Biotinylated
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Cat.#:BMPR2-577HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BMPR2 protein, His & T7-tagged
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Cat.#:BMPR2-868HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human BMPR2 Protein, His-tagged
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Cat.#:BMPR2-870HTag:Fc|His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human BMPR2 Protein, Fc/His-tagged
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Cat.#:BMPR2-2440MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BMPR2 Protein
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Cat.#:BMPR2-549RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BMPR2 Protein, His-tagged
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Cat.#:BMPR2-1108CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BMPR2
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Cat.#:BMPR2-1367HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BMPR2 (Active), His-tagged
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Cat.#:BMPR2-993HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Bone Morphogenetic Protein Receptor, Type II, GST-tagged
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Cat.#:BMPR2-2717HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human BMPR2 cell lysate
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Involved Pathway

BMPR2 involved in several pathways and played different roles in them. We selected most pathways BMPR2 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR3.1; IL6; IL13RA1; Ccl9; TNFRSF18; INHBA; CCL15; LIFRA; TNFSF14; TNF
TGF-beta signaling pathway
SMAD1; NOG2; ACVR1; BAMBIA; BMPR2B; ZFYVE16; CHRD; BMP6; BMPR1B; ID3
Hippo signaling pathway
PPP1CB; WNT5A; TEAD3; WNT7B; TCF7; BTRC; AXIN1; APC; PPP2R2C; YWHAB
Signaling pathways regulating pluripotency of stem cells
INHBC; MYF5; WNT8A; MAPK3; ISL1; IGF1R; PCGF1; LIFR; WNT11; IGF1
MicroRNAs in cancer
GLS2; PTEN; TNXB; MAPK1; ABCB1A; FGFR3; FOXP1; SLC7A1; PDCD4; WNT3A

Protein Function

BMPR2 has several biochemical functions, for example, ATP binding, BMP binding, activin receptor activity, type II. Some of the functions are cooperated with other proteins, some of the functions could acted by BMPR2 itself. We selected most functions BMPR2 had, and list some proteins which have the same functions with BMPR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NME2A; VMHC; PIK3CA; ERBB2; CHKB; TLK1B; PIP4K2C; ATP1A4; MAP3K5; MET
Function BMP binding
Related Protein GDF5; NBL1; CER1; GREM1; GREM2; TCAP; BMPR2; HFE2
Function activin receptor activity, type II
Related Protein BMPR2
Function growth factor binding
Related Protein RPL37; RHBDF2; FLT4; IGFBP2B; ACVR2B; ACVR2A; NKD2; REG3B; OSMR; ACVR1C
Function metal ion binding
Related Protein ZNF69; KAT5; ZFP830; KLK1B4; CYB561D1; ZFP346; ZNF222; PAPD4; MARCH5L; PATZ1
Function protein binding
Related Protein MXD1; TRAF6; RAMP2; SLC9A7; PPP3CB; FAM90A1; C11orf65; TBXAS1; TAF1C; SRRT
Function receptor signaling protein serine/threonine kinase activity
Related Protein STK25A; BMPR1BB; STK26; ACVR1BA; BMPR1B; BMPR2; NEK4; ACVRL1; PAK2A; PAK2B

Interacting Protein

BMPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMPR2.
PRKG1; C4bpa; Prkcb; GDF5; MAPK8; Bmpr2; Ctbp1; Mos; Serpina3k; Lsp1; Cryab

BMPR2 Related Articles

Guignabert, C; Dorfmuller, P; et al. Pathology and Pathobiology of Pulmonary Hypertension. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE 34:551-559(2013).
Yu, J; Taylor, L; et al. Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension. JOURNAL OF CELLULAR PHYSIOLOGY 228:322-329(2013).