CA2
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Official Full Name
Carbonic anhydrase II -
Overview
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. -
Synonyms
CA 2;CA II;CA-II;CA2;CAC;CAH2_HUMAN;CAII;Car 2;Carbonate dehydratase II;Carbonic anhydrase 2;Carbonic anhydrase B;Carbonic anhydrase C;Carbonic anhydrase II;Carbonic dehydratase;EC 4.2.1.1;IUB: 4.2.1.1;CA, HUMAN LIVER;CA1, BOVINE ERYTHROCYTES;CARBONATE DEHYDRATASE;CARBONATE HYDRO-LYASE;CARBONIC ANHYDRASE;PANCREAS, BOVINE;carbonic anhydrase from bovine erythro-cytes;Dehydratase, carbonate;TDX-02;Car-2;Ltw-5;Lvtw-5;AI131712;Car2
Recombinant Proteins
- Human
- Dog
- Mouse
- Sheep
- Rat
- Rabbit
- Rhesus macaque
- Chicken
- Zebrafish
- Capsicum annuum (Bell pepper)
- E.coli
- Dog
- Human
- Mouse
- Sheep
- Rat
- Rabbit
- Rhesus Macaque
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- Yeast
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
- SUMO
Involved Pathway
CA2 involved in several pathways and played different roles in them. We selected most pathways CA2 participated on our site, such as Nitrogen metabolism,Proximal tubule bicarbonate reclamation,Collecting duct acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proximal tubule bicarbonate reclamation | ATP1A1,AQP1,CA4,FXYD2,ATP1A3,GLS,ATP1A2,GLUD1,SLC38A3,ATP1B1 |
| Collecting duct acid secretion | ATP6V1G1,ATP6V0E2,ATP6V0E,ATP6V1F,ATP6V1E2,ATP6V1B2,Car2,ATP4B,ATP6V1D,SLC12A7 |
| Nitrogen metabolism | CA13,Car12,CA8,CAR1,CA5B,Car14,CAR15,CAR6,CAR5A,CPS1 |
| Pancreatic secretion | PNLIPRP1,RHOA,PLCB2,TPCN2,RAB11A,RYR2,CCKAR,ATP1A4,ATP1B3,CELA3B |
| Bile secretion | SLC9A3,SLC22A8,ATP1A2,FAM84B,RXRA,BAAT,ATP1A1,AQP4,OSTB,SLC9A1 |
| Gastric acid secretion | GNAQ,GNAI3,ATP1B1,SLC26A7,SSTR2,CAMK2D,SLC9A1,ATP1B4,KCNK10,PRKACB |
Protein Function
CA2 has several biochemical functions, for example, arylesterase activity,carbonate dehydratase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA2 itself. We selected most functions CA2 had, and list some proteins which have the same functions with CA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CAR7,Car2,CA4B,CAR15,CA14,CA5B,CA1,CAR6,CA4,CAR3 |
| protein binding | NTN1,CDK10,FXR2,HEPACAM2,ALPP,PHYHIPL,MED4,CAMP,SREBF1,IRF2 |
| zinc ion binding | CXXC1A,POLE,NR2F5,ZDHHC14,MAP3K1,BAZ1A,NR1D1,CPSF4,FBLIM1,ZFP276 |
| arylesterase activity | CAR1,Car2,PON3,APMAP,PON1,C20orf3,CA1,PON2 |
Interacting Protein
CA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA2.
Cdk1;PCNA;USP42;ANKZF1;PTCHD2
Resources
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References
- Kale, SL; Arora, N; et al. Per a 10 activates human derived epithelial cell line in a protease dependent manner via PAR-2. IMMUNOBIOLOGY 220:525-532(2015).
- Zhang, Y; Li, H; et al. Melatonin-mediated inhibition of Purkinje neuron P-type Ca2+ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway. JOURNAL OF PINEAL RESEARCH 58:321-334(2015).
