ca2
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  • Official Full Name
  • Carbonic anhydrase II
  • Background
  • Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.
  • Synonyms
  • CA 2; CA II; CA-II; CA2; CAC; CAH2_HUMAN; CAII; Car 2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase; EC 4.2.1.1; IUB: 4.2.1.1; CA, HUMAN LIVER; CA1, BOVINE ERYTHROCYTES; CARBONATE DEHYDRATASE; CARBONATE HYDRO-LYASE; CARBONIC ANHYDRASE; PANCREAS, BOVINE; carbonic anhydrase from bovine erythro-cytes; Dehydratase, carbonate; TDX-02; Car-2; Ltw-5; Lvtw-5; AI131712; Car2
Cat.#:CA2-0237HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA2 Protein
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Cat.#:CA2-0238HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CA2 Protein, GST-Tagged
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Cat.#:Car2-1191MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Carbonic Anhydrase 2, His-tagged
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Cat.#:CA2-354HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA2 protein, His-tagged
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Cat.#:CA2-10619HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA2, GST-tagged
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Cat.#:CA2-1114HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA2 Protein, His-tagged
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Cat.#:CA2-219HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CA2
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Cat.#:CA2-220HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CA2, C13&N15-labeled
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Cat.#:CA2-27265THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA2
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Cat.#:CA2-864HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA2, His tagged
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Cat.#:CAR2-2718MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAR2 Protein
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Cat.#:Car2-886MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Car2 Protein, His-tagged
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Cat.#:CA2-1057RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CA2 Protein
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Cat.#:CA2-597RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CA2 Protein, His-tagged
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Cat.#:CA2-7678RTag:His
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey CA2 protein, His-tagged
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Cat.#:CA2-6869CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CA2
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Cat.#:CA2-7676CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CA2 protein, His-tagged
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Cat.#:CA2-9899ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CA2
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Cat.#:CA2-144HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Carbonic Anhydrase II
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Cat.#:CA2-30HTag:N/A
Source (Host):HumanSpecies:Human
Product nameNative Human Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-31MTag:N/A
Source (Host):MouseSpecies:Mouse
Product nameNative Mouse Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-33RTag:N/A
Source (Host):RatSpecies:Rat
Product nameNative Rat Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-35RTag:N/A
Source (Host):Rhesus monkeySpecies:Rhesus monkey
Product nameNative Rhesus monkey Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-29DTag:N/A
Source (Host):DogSpecies:Dog
Product nameNative Dog Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-34RTag:N/A
Source (Host):RabbitSpecies:Rabbit
Product nameNative Rabbit Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-32STag:N/A
Source (Host):SheepSpecies:Sheep
Product nameNative Sheep Carbonic Anhydrase II (CA2) Protein
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Cat.#:CA2-7915HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CA2 293 Cell Lysate
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Involved Pathway

CA2 involved in several pathways and played different roles in them. We selected most pathways CA2 participated on our site, such as Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nitrogen metabolism
CAR7; CA6; Car9; CAHZ; CA5B; GLUL; GLUD1B; GLUD1; CAR3; CA2
Proximal tubule bicarbonate reclamation
ATP1B4; AQP1; PCK1; GLS; ATP1A3; CA2; PCK2; ATP1A4; SLC9A3; Car4
Collecting duct acid secretion
ATP6V0A4; ATP4A; TCIRG1; ATP6V0D2; ATP6V0A2; ATP6V1B1; ATP6V1F; ATP6V0E; CLCNKB; ATP6V1C1
Gastric acid secretion
CALM4; PRKACB; CAMK2A; PRKCB; MYLK; SST; GNAQ; Slc4a2; PLCB4; ATP4B
Pancreatic secretion
RYR2; AMY2B; CPA1; CLCA3; AMY2A4; AMY2A; PRSS1; PRKCB; PNLIPRP1; PLA2G10
Bile secretion
Car2; CYP3A4; SLCO1B1; ATP1A2; AQP4; AQP8; SLCO1B2; ATP1B3; SCTR; ABCC2

Protein Function

CA2 has several biochemical functions, for example, arylesterase activity, carbonate dehydratase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA2 itself. We selected most functions CA2 had, and list some proteins which have the same functions with CA2. You can find most of the proteins on our site.
Function
Related Protein
Function arylesterase activity
Related Protein CA2; CAR1; PON1; PON2; CA1; APMAP; PON3; C20orf3; Car2
Function carbonate dehydratase activity
Related Protein CAR13; CAR7; Car8; CA15C; Car9; CA4; CA7; CA14; CAR6; CA5B
Function protein binding
Related Protein POMP; SLC3A1; MORF4L1; UBA52; LCE4A; PFKFB1; KRT20; STK4; CIDEB; VPREB1
Function zinc ion binding
Related Protein ZNF207; MMP14A; TRIM14; ZNF184; ZFYVE1; CCS; TRIM61; GALT; SOD3A; EWSR1

Interacting Protein

CA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA2.
Cdk1; PCNA; USP42; ANKZF1; PTCHD2

CA2 Related Articles

Kale, SL; Arora, N; et al. Per a 10 activates human derived epithelial cell line in a protease dependent manner via PAR-2. IMMUNOBIOLOGY 220:525-532(2015).
Zhang, Y; Li, H; et al. Melatonin-mediated inhibition of Purkinje neuron P-type Ca2+ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway. JOURNAL OF PINEAL RESEARCH 58:321-334(2015).