camk2a
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  • Official Full Name
  • calcium/calmodulin-dependent protein kinase II alpha
  • Background
  • The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
  • Synonyms
  • CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;
Cat.#:CAMK2A-0326HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAMK2A Protein, GST-Tagged
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Cat.#:CAMK2A-26210THTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK2A
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Cat.#:CAMK2A-777HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CAMK2A, GST tagged
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Cat.#:CAMK2A-2666MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAMK2A Protein
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Cat.#:CAMK2A-1101RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CAMK2A Protein
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Cat.#:Camk2a-7975RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Camk2a protein, His & T7-tagged
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Cat.#:CAMK2A-5868CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CAMK2A
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Cat.#:CAMK2A-2492ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CAMK2A
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Cat.#:CAMK2A-264HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CAMK2A, GST-tagged, Active
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Cat.#:Camk2a-746RTag:N/A
Source (Host):S. frugiperdaSpecies:Rat
Product nameRecombinant Rat Camk2a
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Cat.#:CAMK2A-1186HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CAMK2A, His-tagged
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Cat.#:CAMK2A-7880HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK2A 293 Cell Lysate
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Cat.#:CAMK2A-7881HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK2A 293 Cell Lysate
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Involved Pathway

CAMK2A involved in several pathways and played different roles in them. We selected most pathways CAMK2A participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PTK2; CAMK2G; AREGB; SHC4; PAK2A; CAMK2D1; PRKCBB; BRAF; HRASA; MYCB
Calcium signaling pathway
ATP2B3B; PHKG1; GNA11A; PLN; PRKCB; PPP3R1B; SLC8A1B; MYLK3; MLCK2; ADCY2B
cAMP signaling pathway
TNNI3; RHOA; CNGA4; ATP1A3; RAP1B; RAC3; MAPK9; ACOX1; GRIN3A; PIK3CB
HIF- signaling pathway
PLCG1; NOS3; CAMK2A; MAPK1; Trf; PIK3CB; ANGPT2; Il6ra; IGF1; PIK3R1
Oocyte meiosis
PGR; PRKACG; PPP1CB; PPP3R1B; CAMK2D2; CALM2B; PPP1CAB; SMC3; CDC16; CCNB1
Adrenergic signaling in cardiomyocytes
CAMK2D2; MAPK14; ATP1A3B; CACNB3A; PPP1CBL; ATF2; PLCB2; ADCY1A; TPM4A; CALM2B
Wnt signaling pathway
PORCN; CAMK2A; PRKACG; FBXW11; DAAM2; SOX17; RHOAA; FZD1; DAAM1; PPP3R1B
Circadian entrainment
PER1; GNG7; CALM4; GNG8; GNAI3; GNB4; CAMK2A; GRIA4; GRIA1; RYR1
Long-term potentiation
MAPK3; PLCB2; PPP3CB; RPS6KA2; PLCB3; CALM3; GRM5; GRIN1; RPS6KA1; PRKCG
Neurotrophin signaling pathway
PIK3CG; PLCG2; MAPK8; PSEN2; RHOA; TP53; YWHAE; PIK3CD; RPS6KA3; AKT2
Cholinergic synapse
KCNQ2; GNG3; CHRNB4; CHRNB2; MAPK1; GNG12; KCNQ4; GNAQ; CAMK4; CREB3L1
Dopaminergic synapse
CREB3L2; GRIN2A; GNAQ; ITPR1; PPP2R5A; DRD1; PPP2R1A; CLOCK; SLC6A3; SLC18A2
Olfactory transduction
OR51B4; ANO2; OLFR154; OR10H1; OLFR18; OLFR498; OLFR1440; CAMK2B; OLFR867; OR10W1
Inflammatory mediator regulation of TRP channels
CYP2C39; CALML3; PLCB4; CYP2C37; ALOX12; IL1RAP; CALM2; PLCB1; PLA2G4A; HRH1
Insulin secretion
ATP1A3; KCNMB2; CCKAR; RIMS2; PRKACA; PLCB2; RAB3A; KCNN2; KCNMB4; RYR2
GnRH signaling pathway
GNRH1; GNA11A; MMP2; PLD2; PRKACB; MAPK14A; MAPK14B; PRKACBA; HRASB; MAPK1
Melanogenesis
GNA15.4; CALML3; MAP2K2; CAMK2D2; GSK3AA; WNT2B; GNAI3; DCT; WNT9B; TCF7
Oxytocin signaling pathway
MYLK; MYLK3; PLCB1; CALM1; NPR2; PIK3CG; CAMK2A; RGS2; PRKACB; MYL6
Glucagon signaling pathway
PHKA1; PPARGC1A; CREB3L1; CRTC2; ATF4; CAMK2D; PHKB; ACACB; CALM1; PLCB2
Aldosterone synthesis and secretion
PRKACA; HSD3B1; SCARB1; AGTR1; MC2R; CREB3L1; PRKCE; CREB3L4; ATF4; SLC14A2
Gastric acid secretion
CALM3; KCNJ16; ATP1A4; CA2; PRKCG; ITPR1; Car2; ATP1A1; SST; ATP1A3
Amphetamine addiction
GRIA2; FOSB; GRIN2A; CREB3L3; GRIN3B; PPP1CA; GRIA3; PPP3CA; SLC6A3; JUN
Tuberculosis
HLA-DQA2; RAB7; CD209A; CLEC4E; BAX; FCGR3A; BCL10; IFNA4; IFNGR1; CYCS
Proteoglycans in cancer
ITGAV; MSN; PAK1; PDPK1; FZD6; TGFB1; CAMK2G; TFAP4; FGF2; SRC
Glioma
BRAF; GRB2; PIK3R3; PIK3CG; TP53; PIK3R1; TGFA; SHC3; IGF1; SHC4

Protein Function

CAMK2A has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2A itself. We selected most functions CAMK2A had, and list some proteins which have the same functions with CAMK2A. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TTN; CLK4; LIMK1; PFKL; ORC5; TSSK5; AK7A; PSMC1; MYH1E; ACSM2
Function calmodulin binding
Related Protein MAPKAPK2; EDF1; CNN1; CAMK2D2; CAMK2B1; NDUFAF4; ASPM; PPP3CA; GAP43; ADCY1
Function calmodulin-dependent protein kinase activity
Related Protein PNCK; CAMK2B1; DAPK1; MKNK1; CAMK1GA; CAMK2B; MKNK2B; NETO2; MAPKAPK5; CAMK4
Function glutamate receptor binding
Related Protein PLCG1; SYNDIG1; GRIN1; GRIN2A; CAMK2A
Function kinase activity
Related Protein TNK2B; CDK5R1B; AGPHD1; PRKD3; NTRK2B; ERBB3B; NLK1; FGGY; PRPS1; ADCK3
Function protein binding
Related Protein MYOM1; GRIK3; MRPL48; AVPR1A; RAB11FIP3; CPSF2; ITM2C; EIF2AK2; CTSH; DAAM1
Function protein homodimerization activity
Related Protein CEACAM5; KLRB1B; Fzd4; MTMR2; GRIK2; KCNN2; MCL1; LGALS6; CBLN1; ACHE
Function protein serine/threonine kinase activity
Related Protein LMTK3; ALPK2; NEK8; VRK3; SMOK3B; BMPR1B; MOS; STK39; FASTK; BRAF

Interacting Protein

CAMK2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2A.
GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5