CAMK2A Protein, calcium/calmodulin-dependent protein kinase II alpha

CAMK2A

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CAMK2A

Official Full Name calcium/calmodulin-dependent protein kinase II alpha
Background The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
Synonyms CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Camk2a-751M Recombinant Mouse Camk2a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CAMK2A-0326H Recombinant Human CAMK2A Protein, GST-Tagged Wheat Germ GST
    Human CAMK2A-1186H Recombinant Human CAMK2A, His-tagged Insect Cell His
    Human CAMK2A-26210TH Recombinant Human CAMK2A N/A
    Human CAMK2A-264H Recombinant Human CAMK2A, GST-tagged, Active Sf9 Insect Cell GST
    Human CAMK2A-777H Recombinant Human CAMK2A, GST tagged Insect Cell GST
    Human CAMK2A-7880HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
    Human CAMK2A-7881HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
    Mouse CAMK2A-2666M Recombinant Mouse CAMK2A Protein Mammalian Cell His
    Rat CAMK2A-1101R Recombinant Rat CAMK2A Protein Mammalian Cell His
    Rat Camk2a-746R Recombinant Rat Camk2a S.frugiperda N/A
    Rat Camk2a-7975R Recombinant Rat Camk2a protein, His & T7-tagged E.coli His/T7
    Chicken CAMK2A-5868C Recombinant Chicken CAMK2A Mammalian Cell His
    Zebrafish CAMK2A-2492Z Recombinant Zebrafish CAMK2A Mammalian Cell His

    CAMK2A involved in several pathways and played different roles in them. We selected most pathways CAMK2A participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway GAB1; MAPK10; CBLC; GRB2B; HBEGFB; KRAS; MAP2K2; CDKN1BB; EGFRA; STAT5A
    Calcium signaling pathway TNNC1B; PLCD1B; VDAC2; TACR1A; MYLK; ADRA1D; ATP2B1A; NOS2B; MYLK2; CACNA1BA
    cAMP signaling pathway PRKACB; GRIA2; PDE4B; HCN4; CNGA3; PDE4A; MAP2K2; MAP2K1; RAC1; FXYD2
    HIF- signaling pathway ENO1; LTBR; AKT2; ENO3; TF; EP300; PIK3R5; IFNGR1; HK1; CAMK2A
    Oocyte meiosis YWHAQB; CALM1; CALM2B; CALM1B; YWHAG1; PPP1CA; PRKACBB; PPP2R5E; MOS; YWHAE2
    Adrenergic signaling in cardiomyocytes CALM2B; PPP2R5D; PLCB3; ATP1B3B; PPP2R5A; ATP2B1; ATP1B2; RAPGEF3; PPP2R3C; ADCY1
    Wnt signaling pathway DKK1; RHOAD; PPARDB; PORCN; LEF1; CTNNBIP1; PRKACBB; CAMK2B; RAC1; WNT7AA
    Circadian entrainment GRIN2D; GNB4; GNG4; PLCB1; GNG3; GNGT2; MTNR1B; CAMK2A; GRIN2B; GNB3
    Long-term potentiation PRKACA; PPP3CB; PRKACB; CAMK2D; GRIA1; CALM2; EP300; CALML5; ARAF; PPP1CB
    Neurotrophin signaling pathway RAP1B; PIK3R2; TRP53; TP53; CAMK2G; ABL1; CALM2; GAB1; ZNF274; RAF1
    Cholinergic synapse KCNQ5; GNG13; PLCB2; GNGT2; JAK2; HRAS; GNG3; AKR1C1; PIK3CG; KCNJ14
    Dopaminergic synapse GNB2; GNB4; CREB3; MAOB; KIF5A; PPP2R5A; PPP2R2B; MAPK8; CREB3L4; CALY
    Olfactory transduction OR3A2; OR13A1; OLFR11; OLFR186; PRKACA; OLFR477; OR12D3; OR4D6; OLFR486; OLFR470
    Inflammatory mediator regulation of TRP channels PTGER2; PPP1CA; HRH1; F2RL1; PLA2G6; MAPK10; TRPV1; PLCG1; PIK3R3; PLA2G4F
    Insulin secretion GNAS; GPR119; RAB3A; PCLO; KCNMB1; FXYD2; KCNN2; PRKCA; INS; CAMK2B
    GnRH signaling pathway MAP3K3; RAF1B; MAPK9; GNRHR1; CALM1; CALM3; ADCY2B; PLCB3; PRKACB; GNRH1
    Melanogenesis RAF1B; PRKCA; KIT; PRKACBB; PRKACAB; CALM1A; WNT11; WNT3; ADCY1B; ASIP
    Oxytocin signaling pathway ACTG1; GUCY1B3; CACNA2D2; CALML5; GNAQ; CAMK4; PRKAG2; PPP1R12C; CAMK2D; ACTB
    Glucagon signaling pathway PRKAA1; PRKACG; CREB3L3; PPP3CC; ACACA; ATF4; PRKAG3; PRKACB; PYGB; PRKACA
    Aldosterone synthesis and secretion PRKCA; STAR; PLCB1; PRKACB; LDLR; CALM1; CAMK2G; CREB3L3; HSD3B4; CREB3L1
    Gastric acid secretion GNAI1; ACTB; ATP1A2; ITPR1; KCNQ1; SSTR2; PLCB2; CAMK2A; CA2; MYLK
    Amphetamine addiction PPP3R1; GRIA1; GRIN3B; ATF4; ATF6B; PPP1CC; NETO2; PRKCA; SLC18A1; STX1A
    Tuberculosis Il23a; NFYB; MRC1; Itgam&Itgb2; CALM4; NFYC; ATP6V0D2; RAB5C; IFNA1; LAMP2
    Proteoglycans in cancer PRKCA; ITPR1; PRKACB; ARHGEF12; TFAP4; ITGB5; CBLC; CD44; RPS6KB2; FZD7
    Glioma SHC4; TRP53; MAPK1; PRKCG; PTEN; GRB2; AKT2; TP53; KRAS; CAMK2A

    CAMK2A has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2A itself. We selected most functions CAMK2A had, and list some proteins which have the same functions with CAMK2A. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding RIPK1L; RET; ATP11A; ACTG2; OBSCN; DNAJA3; HIPK1; ATP1A1A.4; DAPK2A; LONP1
    calmodulin binding MYO1G; ATPIF1; MAP6; GEM; CAMKK2; MAPKAPK2; GRIN1; TRPC2; SMTNL1; PATE4
    calmodulin-dependent protein kinase activity MYLK2; MKNK2B; CAMK1D; CAMK2D1; MAPKAPK5; DCX; CAMK2B1; CAMK2G; DAPK1; CAMK1
    glutamate receptor binding GRIN1; PLCG1; SYNDIG1; GRIN2A; CAMK2A
    kinase activity PRKCDA; CAMK2N1A; PRKAR2AB; PKMA; PDK2B; CDC7; PFKFB2A; NADKD1; MAPK8B; CDKN1D
    protein binding ABT1; CHMP4A; FOXD3; CAB39L; LLGL2; KIRREL; PARVG; CUBN; PDE6G; SEPT7
    protein homodimerization activity TOP2A; GAMT; TFAP2A; BCL2A1A; HLA-G; ANXA1; CTBP2A; HOGA1; HARS2; HMGCS1
    protein serine/threonine kinase activity RAF1; NEK2; PRKACBA; SRPK3; CAMKK1A; STK32C; SPEG; LRRK1; DAPK3; TTK

    CAMK2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2A.

    GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5

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