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CAMK2A

  • Official Full Name

    calcium/calmodulin-dependent protein kinase II alpha

  • Overview

    The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
  • Synonyms

    CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CAMK2A-26210TH Recombinant Human CAMK2A N/A
Human CAMK2A-264H Recombinant Human CAMK2A, GST-tagged, Active Sf9 Insect Cell GST
Human CAMK2A-777H Active Recombinant Human CAMK2A protein, GST-tagged Insect Cells GST Met1-His478
Human CAMK2A-1186H Recombinant Human CAMK2A, His-tagged Insect Cell His
Human CAMK2A-0326H Recombinant Human CAMK2A Protein, GST-Tagged Wheat Germ GST
Human CAMK2A-7881HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
Human CAMK2A-7880HCL Recombinant Human CAMK2A 293 Cell Lysate HEK293 N/A
Human CAMK2A-9765HF Active Recombinant Full Length Human CAMK2A Protein, GST-tagged Insect (sf21) GST 1-478(end)
Human CAMK2A-2759HF Recombinant Full Length Human CAMK2A Protein, GST-tagged In Vitro Cell Free System GST 478 amino acids
Human CAMK2A-6286H Recombinant Human CAMK2A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CAMK2A-3395H Recombinant Human CAMK2A protein, His-tagged E.coli His 1-271 aa
Human CAMK2A-508HFL Active Recombinant Full Length Human CAMK2A Protein, C-Flag-tagged Mammalian cells Flag
Human CAMK2A-490H-B Recombinant Human CAMK2A Protein Pre-coupled Magnetic Beads HEK293
Human CAMK2A-0178H Recombinant Human CAMK2A Protein (A2-H478), GST tagged Insect Cell GST A2-H478
Human CAMK2A-0177H Recombinant Human CAMK2A Protein (A2-H478), Tag Free Insect Cell No tag A2-H478
Human CAMK2A-490H Recombinant Human CAMK2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAMK2A-2666M Recombinant Mouse CAMK2A Protein Mammalian Cell His
Mouse CAMK2A-1197M Recombinant Mouse CAMK2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CAMK2A-1197M-B Recombinant Mouse CAMK2A Protein Pre-coupled Magnetic Beads HEK293
Mouse Camk2a-751M Recombinant Mouse Camk2a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Camk2a-746R Active Recombinant Rat Camk2a S.frugiperda N/A
Rat Camk2a-7975R Recombinant Rat Camk2a protein, His & T7-tagged E.coli His/T7 Met1~His478 (Accession # P11275)
Rat CAMK2A-1101R Recombinant Rat CAMK2A Protein Mammalian Cell His
Rat CAMK2A-765R Recombinant Rat CAMK2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CAMK2A-765R-B Recombinant Rat CAMK2A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CAMK2A-2492Z Recombinant Zebrafish CAMK2A Mammalian Cell His
Chicken CAMK2A-5868C Recombinant Chicken CAMK2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CAMK2A Related Research Area

CAMK2A involved in several pathways and played different roles in them. We selected most pathways CAMK2A participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayPLCG2;KRAS;CDKN1BA;PAK1;MAPK9;NCK2;GAB1;PIK3R5;STAT5B
Calcium signaling pathwayPHKG1;EDNRB2;ADCY1A;CYSLTR2;NOS1;ORAI2;LTB4R2;CD38;HTR5AL
cAMP signaling pathwayVIPR2;CALM1;RAC1;ATP2B1;F2R;CREB5;ATP1B1;ATP1B3;GNAI3
HIF- signaling pathwayGAPDH;PIK3CA;PIK3R3;PDHA2;RPS6KB1;PLCG1;SERPINE1;PIK3CD;MTOR
Oocyte meiosisMAP2K1;SMC1AL;ANAPC13;SKP1;RPS6KA3A;PPP2R5C;RPS6KA2;SLK;CALM2A
Adrenergic signaling in cardiomyocytesPPP1CBL;MAPK12A;PPP1CAA;CALM2;PPP1CAB;CALM1A;TNNT2A;ATP1B3B;PPP2R2BB
Wnt signaling pathwayWNT11R;PRKACAB;RUVBL1;PPARD;TLE3A;DAAM2;WNT2BB;DAAM1B;PRKACBA
Circadian entrainmentGNGT2;CAMK2B;GNG8;GUCY1B3;RYR1;GRIA2;GRIN2C;CALML3;GRIA4
Long-term potentiationCAMK2A;CALM1;RPS6KA1;GRM5;CALML5;GRIN2C;PPP1CB;PPP1CA;PRKACB
Neurotrophin signaling pathwayNFKB1;SH2B2;PSEN2;SHC3;Fasl;NGFR;PIK3CG;CAMK2D;NTRK3
Cholinergic synapsePRKACG;PIK3R3;PRKACA;GNGT2;GNGT1;CREB3;CHRNA7;KCNQ2;PIK3CB
Dopaminergic synapseATF4;CREB3L3;CALML5;CREB3;CAMK2D;PPP2R5E;CAMK2A;GSK3B;PPP2R5B
Olfactory transductionOR51D1;OR4D2;OLFR958;OR5H1;OLFR470;ANO2;OR2AP1;OLFR49;OR10J1
Inflammatory mediator regulation of TRP channelsGNAS;PLA2G4D;CYP4A12A;PIK3CD;CALM3;PRKCE;HRH1;PRKCD;MAPK13
Insulin secretionRAPGEF4;RYR2;GNAQ;CAMK2A;FXYD2;INS1;PLCB1;ATP1B4;INS
GnRH signaling pathwayAdcy4;ATF4B1;PLA2G4C;CALM3;MAPK14B;PLD1;CALM1B;GNRHR1;GNA15.1
MelanogenesisWNT8A;POMCA;CAMK2B;MC1R;MITF;PLCB4;KITA;PRKACA;PRKACBB
Oxytocin signaling pathwayPRKCA;PLA2G4F;CAMK2G;CACNA2D1;GUCY1A3;PRKAG2;NPR2;RYR3;SRC
Aldosterone synthesis and secretionSCARB1;CREB3L3;PRKD2;ITPR2;CAMK2G;CALML5;HSD3B2;CAMK1;ATF4
Gastric acid secretionGNAQ;CA2;PLCB1;PRKCA;KCNK2;KCNE2;GAST;SLC26A7;ATP1B1
TuberculosisMRC2;ITGAM;RELA;CALML5;PPP3CB;IFNA21;FADD;PPP3R2;IFNA4
Proteoglycans in cancerSRC;CD63;IL12B;ACTB;HIF1A;WNT7A;TIMP3;PTPN6;CAMK2D
GliomaSHC3;PDGFRB;IGF1;CAMK2D;TP53;KRAS;CCND1;SHC1;PIK3R3

CAMK2A has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2A itself. We selected most functions CAMK2A had, and list some proteins which have the same functions with CAMK2A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYO3B;GRK4;DDX3X;Abcb1b;VRK2;CKBB;DNAJA3;CBWD2;TSSK2
calmodulin bindingCNN3B;CDK5RAP2;ADCY3;MARCKSL1B;OBSCN;RIT2;PPP3R1;PHKB;PPP3CC
calmodulin-dependent protein kinase activityMYLK3;CAMKK1;CAMK1GB;DCX;CAMK2D1;CAMK2G;MKNK2B;CAMK2D2;DAPK2A
glutamate receptor bindingGRIN2A;SYNDIG1;PLCG1;GRIN1;CAMK2A
kinase activityBMPR1BB;DNAJC3B;UCK2A;FGFR1A;PRPS1;DYRK1AA;NR5A1B;GRK7A;PLK2B
protein bindingTMEM171;C7orf53;AEBP2;PTPRZ1;ERLEC1;SCG5;VDAC2;BCL2L1;PIP5K1B
protein homodimerization activityMAPK4;CUBN;CACYBP;IDH1;S100A13;MYO7A;CRYBA1;XPNPEP1;ATPIF1B
protein serine/threonine kinase activityACVRL1;HIPK1;OXSR1B;TAF1;MKNK1;ADCK1;NEK6;ZAK;HIPK3

CAMK2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2A.

GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5

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