camk2a
Share
  • Official Full Name
  • calcium/calmodulin-dependent protein kinase II alpha
  • Background
  • The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
  • Synonyms
  • CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha;
Cat.#:CAMK2A-0326HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAMK2A Protein, GST-Tagged
+Inquiry
Cat.#:CAMK2A-26210THTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK2A
+Inquiry
Cat.#:CAMK2A-777HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CAMK2A, GST tagged
+Inquiry
Cat.#:CAMK2A-2666MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAMK2A Protein
+Inquiry
Cat.#:CAMK2A-1101RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CAMK2A Protein
+Inquiry
Cat.#:Camk2a-7975RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Camk2a protein, His & T7-tagged
+Inquiry
Cat.#:CAMK2A-5868CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CAMK2A
+Inquiry
Cat.#:CAMK2A-2492ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CAMK2A
+Inquiry
Cat.#:CAMK2A-264HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CAMK2A, GST-tagged, Active
+Inquiry
Cat.#:Camk2a-746RTag:N/A
Source (Host):S. frugiperdaSpecies:Rat
Product nameRecombinant Rat Camk2a
+Inquiry
Cat.#:CAMK2A-1186HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CAMK2A, His-tagged
+Inquiry
Cat.#:CAMK2A-7880HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK2A 293 Cell Lysate
+Inquiry
Cat.#:CAMK2A-7881HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK2A 293 Cell Lysate
+Inquiry

Involved Pathway

CAMK2A involved in several pathways and played different roles in them. We selected most pathways CAMK2A participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PIK3R3B; ARAF; MAP2K1; GRB2A; HRASB; BRAF; SOS1; PLCG1; HRASA; PAK6
Calcium signaling pathway
P2RX8; RYR1B; GNA11A; PLCG2; NOS3; RYR2; SLC8A4A; CACNA1DA; ADRA1B; EDNRB2
cAMP signaling pathway
MC2R; BRAF; HTR1A; BDNF; GPR81; SLC9A1; CAMK2A; PIK3R2; PDE3B; HTR1E
HIF- signaling pathway
CUL2; HK1; NOS3; NFKB1; PRKCB; EP300; INSR; PDHB; GAPDH; PDHA1
Oocyte meiosis
RPS6KA3A; CAMK2A; CAMK2D2; CPEB1B; SPDYA; CALM4; CUL1B; YWHAE2; RPS6KA1; CALM3A
Adrenergic signaling in cardiomyocytes
PIK3CB; CALM3B; ATP2A2; CALM; ADCY3; GNAI2; CAMK2G; GNAQ; PPP1CAA; ADRA1BB
Wnt signaling pathway
PLCB1; WNT2BA; WNT8A; NFATC3; FZD3B; SKP1; SFRP1; CAMK2G1; FZD2; FOSL1A
Circadian entrainment
ITPR1; GNG3; CAMK2D; KCNJ5; GNAS; CALM1; PRKCB; KCNJ6; GNAQ; PER1
Long-term potentiation
RAP1A; RPS6KA6; ARAF; CALML3; GRIA2; RAF1; CALM3; HRAS; CALML5; PPP3CA
Neurotrophin signaling pathway
PDPK1; PLCG2; MAP3K1; ABL1; RPS6KA3; PIK3CB; MAGED1; SORT1; PLCG1; NFKB1
Cholinergic synapse
KCNQ1; PIK3CD; CREB3; CHRM2; CAMK2D; GNG5; KCNJ12; CHRNA4; PRKACB; FYN
Dopaminergic synapse
GRIA2; PRKACB; GSK3A; PRKCA; PPP2R5C; GNG12; CLOCK; DRD1; PRKCG; GRIA3
Olfactory transduction
OR4D6; OLFR147; OR10C1; OLFR491; OR2K2; CLCA1; OR4C13; OLFR18; OLFR998; PRKG1
Inflammatory mediator regulation of TRP channels
MAPK10; IL1R1; PLA2G4C; CALML3; CYP2C39; PIK3CB; CAMK2A; ASIC5; PRKCQ; ASIC1
Insulin secretion
PRKCB; KCNN3; CAMK2G; PRKCA; ATP1A3; FFAR1; ITPR3; Adcy4; CAMK2A; ATP1B3
GnRH signaling pathway
CAMK2G; PRKCBB; PRKCA; PRKACAA; GNRHR4; MAPK8B; CACNA1C; ELK1; PRKCBA; ATF4B1
Melanogenesis
PRKACAB; HRAS; FZD8A; PRKACG; EDNRBA; ADCY2B; WNT4; DVL3A; PLCB1; FZD7A
Oxytocin signaling pathway
SRC; GUCY1A3; RYR2; HRAS; CACNA2D4; PPP1R12C; KRAS; GNAS; GUCY1B3; PLCB3
Glucagon signaling pathway
EP300; CREB3L1; PRKAA2; PLCB4; PRKACA; FBP1; SMEK1; PCK1; LDHAL6A; PPP4C
Aldosterone synthesis and secretion
CAMK1G; PLCB3; AGTR1; PRKACG; ADCY1; PRKD3; CALM1; Adcy4; PRKACB; HSD3B6
Gastric acid secretion
KCNK10; PLCB4; CALM4; ATP1A1; PLCB3; KCNJ15; CALM1; Car2; CAMK2G; PLCB1
Amphetamine addiction
PPP1CB; SLC18A2; DDC; CREB3L4; STX1A; HDAC1; PPP3R1; PRKCA; SLC6A3; DRD1
Tuberculosis
MAPK13; NFYB; RIPK2; H2-AB1; CAP18; MAPK8; SPHK2; IFNGR1; FCGR2B; MAPK12
Proteoglycans in cancer
PLAU; TFAP4; WNT9A; PRKACA; ANK2; PPP1CB; TGFB1; FZD2; VTN; MRAS
Glioma
MAPK1; AKT1; NRAS; PRKCA; MDM2; RB1; PRKCG; MAP2K1; SHC3; TGFA

Protein Function

CAMK2A has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2A itself. We selected most functions CAMK2A had, and list some proteins which have the same functions with CAMK2A. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2O; ORC4L; TTLL12; UBE2D3; PTK2BB; NTPCR; NLRP1; SWAP70; ACTB1; KIF9
Function calmodulin binding
Related Protein PLCB3; KCNH5; GM101; PLA2G6; SLC14A2; MARCKS; KCNN3; CAMK2G; MYO1D; MYH13
Function calmodulin-dependent protein kinase activity
Related Protein DAPK2A; CAMK1G; NETO2; CAMK1D; MKNK2A; MAPKAPK2A; DAPK1; CAMK2D2; CAMKK2; MAPKAPK2B
Function glutamate receptor binding
Related Protein CAMK2A; SYNDIG1; PLCG1; GRIN2A; GRIN1
Function kinase activity
Related Protein CSNK2A2A; PKMB; NADKD1; JAK2B; SRC; BMPR1AA; PRKCHA; PKN1B; TAB3; EK1
Function protein binding
Related Protein CBR4; DDX39A; C11orf67; BMP10; C19orf25; MYLK; KIF18B; KIF3B; CCT5; HOXB9
Function protein homodimerization activity
Related Protein CRYAB; ENO2; PRLR; PDXK; DDX1; HMGCL; S100A1; ATPIF1; PCYT1A; ACCS
Function protein serine/threonine kinase activity
Related Protein MYO3B; PAK2A; EIF2AK4; DCAMKL2; BMPR1A; TTK; RIOK2; DYRK1A; MAP3K10; PIM3

Interacting Protein

CAMK2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2A.
GRIN2B; ACTN1; CAMK2D; calcium(2+); PPM1F; fem-2; RCHY1; Ppm1f; HSP90AB1; NR2F6; CALM1; CAMK2B; SMAD2; DLG3; CHMP5