casp9
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  • Official Full Name
  • caspase 9, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Synonyms
  • CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;
Cat.#:CASP9-0433HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP9 Protein, GST-Tagged
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Cat.#:CASP9-148HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 Protein, His-tagged
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Cat.#:CASP9-34HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human Caspase-9 Enzyme
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Cat.#:CASP9-48HTag:MYC/DDK
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CASP9 protein, MYC/DDK-tagged
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Cat.#:CASP9-49HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein
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Cat.#:CASP9-584HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP9
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Cat.#:CASP9-626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein, His-tagged
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Cat.#:CASP9-627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein, His-tagged
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Cat.#:CASP9-2758MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP9 Protein
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Cat.#:Casp9-628MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp9 protein, His-tagged
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Cat.#:Casp9-629RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp9 protein, His-tagged
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Cat.#:CASP9-1788ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP9
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Cat.#:CASP9-618HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9
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Cat.#:Casp9-679MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Caspase 9
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Cat.#:CASP9-7828HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP9 293 Cell Lysate
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Involved Pathway

CASP9 involved in several pathways and played different roles in them. We selected most pathways CASP9 participated on our site, such as p signaling pathway, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
BIDA; SIAH1; PTENB; PMAIP1; CASP3B; IGFBP3; SESN2; EI24; SFN; RPRMA
PIK-Akt signaling pathway
G6PC; TCL1B1; GNGT2; ITGB6; PKN1; STK11; BCL2; RAF1; EIF4E1B; IFNB1
Apoptosis
H1F0; CFLAR; CYCSB; CRADD; PPP3R1B; IL1A; DSG1; NFKBIAB; MYD88; CAPN2B
VEGF signaling pathway
PIK3CG; VEGFAB; RAF1B; RAC3A; CDC42; PIK3R3; BADB; PLA2G4A; MAP2K1; PLA2G4C
Thyroid hormone signaling pathway
ATP1B4; BMP4; RXRA; CCND1; MED13L; ATP1B3; TSC2; FOXO1; MTOR; MED27
Alzheimers disease
CAPN2; Casp3; NDUFS7; CASP7; CALM3; SDHD; NDUFA4; ATP5O; NDUFA6; IL1B2
Parkinsons disease
NDUFA4; GNAI2; NDUFA9; NDUFA4L2; NDUFA11; NDUFC1; NDUFA1; mt-Atp8; MT-ND1; GPR37
Amyotrophic lateral sclerosis (ALS)
GRIN2A; PPP3R2; GRIN1; MAPK13; TNFRSF1B; NEFL; MAPK12; GPX1; PPP3CB; BAD
Huntingtons disease
POLR2A; NDUFAB1; SLC25A4; ATP5F1; Atp5g2; BBC3; COX6A2; SDHB; NDUFA2; DNAH5
Legionellosis
CASP9; SAR1A; TLR5; PYCARD; HSF1; ITGAM; RAB1B; NLRC4; NAIP6; HSPA1A
Toxoplasmosis
HLA-DRB1; LAMA5; TRAF6; LAMC2; BIRC7; LAMB2; LAMC1; CYCS; GNAI1; TNF
Tuberculosis
TRAF6; RELA; CD209C; CAMP; HLA-DRB1; HLA-DMB; CYCS; MAPK10; HLA-DPB1; ATP6V1H
Hepatitis B
PRKCA; IFNB1; TRP53; IRF3; BIRC5; PIK3R2; IFN-a; NFATC1; PTEN; CASP9
Influenza A
IL-8; PIK3R1; NUP98; FURIN; HLA-DPA1; IFNA10; OAS1A; STAT2; IL1A; BCL2L2-PABPN1
Pathways in cancer
APC2; TPM3; SOS1; Fgf15; WNT2; RXRA; PTGER2; FGF14; APC; SPI1
Colorectal cancer
KRAS; TGFBR1; PIK3R3; PIK3CB; RAF1; MAPK10; PIK3CA; LEF1; SMAD4; SMAD3
Pancreatic cancer
RAC3; VEGFA; MAPK1; ARAF; BRCA2; MAP2K1; PIK3CB; MAPK3; TP53; SMAD4
Endometrial cancer
AXIN2; KRAS; RAF1; PIK3CA; CASP9; CTNNA2; FOXO3; PIK3CD; PIK3CG; PIK3CB
Prostate cancer
KRAS; LEF1; CREB3L1; HSP90AA1; FOXA1; MAPK1; PDGFRA; PDPK1; CREB3L2; AKT2
Small cell lung cancer
AKT1; BIRC7; APAF1; PIAS2; ITGA2; CYCS; PIK3CB; TRAF5; PIK3R1; PIK3CG
Non-small cell lung cancer
RASSF5; PIK3R5; STK4; RXRA; PIK3CD; TP53; PIK3CB; SOS1; KRAS; PIK3R2
Viral myocarditis
ICAM1; H2-AB1; HLA-DOB; FYN; HLA-DQA2; CD80; Casp3; HLA-DRB1; SGCG; HLA-DMB

Protein Function

CASP9 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP9 itself. We selected most functions CASP9 had, and list some proteins which have the same functions with CASP9. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein INPPL1B; SH3BP5; CIT; EVL; HCLS1; PTPN22; CBL; ELMO1; SIRPA; SHANK1
Function cysteine-type endopeptidase activity
Related Protein USP5; ATG4D; USP38; ATG4C; USP2; CTSC; CTLA2B; USP30; CTSH; USP40
Function cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Related Protein CASP14; CASP10; CASP2; CASP8; CFLAR; CASP8L1; CASP9; CFLARA
Function enzyme activator activity
Related Protein CTAGE5; DBF4; GMFB; ALDH1A2; SFTPB; PRKCE; MMP17; GM1679; PRKCD; GTF3C4
Function peptidase activity
Related Protein ASTL; DESI2; PM20D1; AGBL1; F2RL1.1; KLK1B3; ADAMTS7; lon; C1RA; USP9
Function protein binding
Related Protein SH2D1B; C7orf50; RNF168; BRD8; NLRP2; TIE1; TGFA; SNX10; PFDN4; MAB21L1
Function protein kinase binding
Related Protein SPRY2; PPP1R12A; KIF13B; SOCS1; GPRC5B; TPX2; BCL10; NBEA; MAP2K3; SPDYA

Interacting Protein

CASP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP9.
XIAP; APAF1