casp9
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  • Official Full Name
  • caspase 9, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Synonyms
  • CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;
Cat.#:CASP9-0433HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP9 Protein, GST-Tagged
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Cat.#:CASP9-148HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 Protein, His-tagged
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Cat.#:CASP9-34HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human Caspase-9 Enzyme
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Cat.#:CASP9-48HTag:MYC/DDK
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CASP9 protein, MYC/DDK-tagged
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Cat.#:CASP9-49HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein
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Cat.#:CASP9-584HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP9
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Cat.#:CASP9-626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein, His-tagged
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Cat.#:CASP9-627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein, His-tagged
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Cat.#:CASP9-2758MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP9 Protein
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Cat.#:Casp9-628MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp9 protein, His-tagged
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Cat.#:Casp9-629RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp9 protein, His-tagged
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Cat.#:CASP9-1788ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP9
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Cat.#:CASP9-618HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9
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Cat.#:Casp9-679MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Caspase 9
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Cat.#:CASP9-7828HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP9 293 Cell Lysate
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Involved Pathway

CASP9 involved in several pathways and played different roles in them. We selected most pathways CASP9 participated on our site, such as p signaling pathway, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
RPRM; TP73; CASP3B; CCNB1; PERP; BAX; ZMAT3; MDM4; PTEN; BAI1
PIK-Akt signaling pathway
ITGA6; RAF1; ITGB1; FGF4; PPP2R5C; LAMB4; CREB3L1; GNB3; VEGFB; PPP2R2A
Apoptosis
RIPK1L; PPP3R2; DYNLL2; ATM; NFKBIA; AIFM1; JUN; IRAK1; IRF4; PIK3CA
VEGF signaling pathway
VEGFAA; SH2D2A; MAPKAPK3; VEGFAB; MAPK12; HRASB; PLA2G4A; NOS3; MAPK1; SPHK2
Thyroid hormone signaling pathway
ATP1B1; HDAC1; RXRG; MED17; NCOR1; PIK3CD; DIO2; MED12L; NCOA3; SLC16A10
Alzheimers disease
CALM3; CALML5; NDUFB2; CAPN1; UQCR11; ITPR2; COX7A2; NDUFA13; NDUFA3; ATP5F1
Parkinsons disease
SEPT5; UBE2G2; NDUFS1; NDUFB5; NDUFC2; NDUFA10; ATP5G1; NDUFA13; PPIF; PINK1
Amyotrophic lateral sclerosis (ALS)
MAPK12; MAP2K3; GRIN2B; DERL1; PPP3CB; BID; CASP9; PPP3R2; ALS2; GRIN2D
Huntingtons disease
BAX; NDUFS3; ATP5J; SLC25A5; PPIF; NDUFB8; UQCR10; COX5B; DNALI1; ATP5F1
Legionellosis
NLRC4; NFKB2; RELA; CXCL1; BCL2L13; NAIP6; HSPD1; SAR1A; HSPA1L; IL6
Toxoplasmosis
HLA-DRB4; LAMA3; HLA-DRB3; ALOX5; MAPK13; HLA-DOA; PIK3CD; GNAI1; IFNGR1; AKT1
Tuberculosis
Il23a; MAPK11; CAMK2B; IFNA17; IFNA4; BCL2; EP300; CALM2; MYD88; FCGR1A
Hepatitis B
IFNA14; STAT6; PIK3R3; DDX58; TGFB1; MAPK1; IL6; IFNA1; AKT1; YWHAZ
Influenza A
PIK3CA; MAPK3; OAS1A; MX1; BCL2L2-PABPN1; CASP1; IL8L1; EIF2AK1; HLA-DQA2; IFNA5
Pathways in cancer
IKBKG; ITGA2; WNT8A; VHL; WNT3; NCOA4; MAPK9; BIRC3; WNT9A; FGF8
Colorectal cancer
DCC; APC; BRAF; MLH1; APC2; MAPK3; MSH6; CASP9; RHOA; TP53
Pancreatic cancer
RAC2; TGFBR1; RALBP1; AKT1; ARAF; SMAD4; MAPK3; IKBKB; ARHGEF6; VEGFA
Endometrial cancer
PIK3R5; PIK3CD; TRP53; PIK3CA; PIK3R2; TCF7L2; CTNNA3; KRAS; CASP9; PIK3CG
Prostate cancer
PIK3CA; AKT2; MAP2K1; NFKBIA; CCNE2; ARAF; CREB5; TP53; LEF1; PDGFC
Small cell lung cancer
AKT2; LAMA4; COL4A1; AKT1; PIK3R5; PIK3CA; SKP2; BIRC3; LAMB4; BIRC7
Non-small cell lung cancer
KRAS; RXRB; RASSF5; FOXO3; PIK3CA; MAP2K1; MAPK3; EML4; PRKCB; NRAS
Viral myocarditis
HLA-DRB5; HLA-DQA2; CD28; ABL2; HLA-F; HLA-A; HLA-G; MYH7; CD40LG; H2-Q10

Protein Function

CASP9 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP9 itself. We selected most functions CASP9 had, and list some proteins which have the same functions with CASP9. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein GRIK5; SH3BGR; CNTNAP1; CYBA; ARHGAP27; ARHGAP1; CASP9; CCDC6; HCLS1; QKI
Function cysteine-type endopeptidase activity
Related Protein FMNL3; CFLARA; USP27X; CASPBL; CTSZ; CASP10; USP49; CTSB; CASP2; USP9X
Function cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Related Protein CFLARA; CASP2; CFLAR; CASP9; CASP8; CASP14; CASP8L1; CASP10
Function enzyme activator activity
Related Protein RAB3GAP2; TIMP2; GM1679; GMFB; DBNL; CASP9; TAB1; RICTOR; CTSA; OGT
Function peptidase activity
Related Protein ELA2L; BMP1A; BAP1; ELA2; GZMC; CTSJ; KLK1B24; CTSH; CTSG; MALT1
Function protein binding
Related Protein Ctsl; MAGI2; GPA33; TSPYL4; MKL1; CLDN8; MEF2D; CNIH2; PIP4K2B; FRS3
Function protein kinase binding
Related Protein RFFL; MAPK6; CCNL2; RAB11FIP2; AP2A1; TRIM5; PRKAG3; PTPN1; DAXX; PIH1D1

Interacting Protein

CASP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP9.
XIAP; APAF1