casp9
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  • Official Full Name
  • caspase 9, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Synonyms
  • CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;
Cat.#:CASP9-0433HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP9 Protein, GST-Tagged
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Cat.#:CASP9-148HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 Protein, His-tagged
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Cat.#:CASP9-34HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human Caspase-9 Enzyme
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Cat.#:CASP9-48HTag:Myc|DDK
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CASP9 protein, MYC/DDK-tagged
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Cat.#:CASP9-49HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein
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Cat.#:CASP9-584HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP9
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Cat.#:CASP9-626HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein, His-tagged
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Cat.#:CASP9-627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9 protein, His-tagged
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Cat.#:CASP9-2758MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP9 Protein
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Cat.#:Casp9-628MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp9 protein, His-tagged
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Cat.#:Casp9-629RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp9 protein, His-tagged
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Cat.#:CASP9-1788ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP9
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Cat.#:CASP9-618HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP9
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Cat.#:Casp9-679MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Caspase 9
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Cat.#:CASP9-7828HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CASP9 293 Cell Lysate
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Involved Pathway

CASP9 involved in several pathways and played different roles in them. We selected most pathways CASP9 participated on our site, such as p signaling pathway, PIK-Akt signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
CASP8; SESN1; CASP3B; RPRMA; CCNE2; COP1; CYCSB; BIDA; CCND3; STEAP3
PIK-Akt signaling pathway
FGF20; IL7; FGFR2; CD19; GNG8; IFNA4; PPP2R5D; IGF1; LAMB1; HSP90AB1
Apoptosis
HELLS; DFFB; VIML; DSG2; BCL2L11; IRF2A; XIAP; PRKAR1B; HIST1H1A; CASP7
VEGF signaling pathway
PLA2G4AA; MAPK13; PPP3CCA; PIK3R1; PPP3CCB; PTK2; PIK3R3; PLA2G4A; SH2D2A; RAC1
Thyroid hormone signaling pathway
PRKACB; MED27; PLCB3; GATA4; WNT4; MED30; NOTCH2; HDAC2; ITGAV; SLC2A1
Alzheimers disease
ATP5J; GNAQ; NDUFC2-KCTD14; NDUFC2; ATP2A2; CASP12; APP; PSENEN; NDUFA12; ATP5E
Parkinsons disease
NDUFA2; NDUFV2; GNAI3; NDUFB11; ATP5O; ATP5G3; PRKACA; SEPT5; UQCRFS1; COX8C
Amyotrophic lateral sclerosis (ALS)
MAPK11; TOMM40L; Casp3; PPP3CA; BID; CASP12; BAX; GRIN2A; TNFRSF1B; NEFL
Huntingtons disease
NDUFA6; POLR2C; SLC25A31; TFAM; NDUFB5; COX7A2L; EP300; HTT; COX8A; POLR2F
Legionellosis
SAR1A; ITGAM; C3; HSPA1L; CASP7; HSF1; NFKBIA; SEC22B; CLK1; Itgam&Itgb2
Toxoplasmosis
TLR4; H2-AA; HLA-DMA; HSPA8; PIK3CD; MAP3K7; NFKB1; BIRC7; IL12A; HSPA6
Tuberculosis
Casp3; IL12A; LAMP2; FCGR4; APAF1; FCGR1A; IFNA8; CAMK2G; LAMP1; ITGB2
Hepatitis B
STAT4; FAS; SRC; IFNA13; CCNA1; PRKCA; YWHAB; CREB3L3; IFNA17; Ifna11
Influenza A
RAF1; LOC100033925; HLA-DQA1; IFNA5; AGFG1; Ccl12; IFNGR2; HLA-DRB5; IFNA7; IFNA16
Pathways in cancer
RB1; AKT2; GNB3; LPAR2; PIK3CD; RXRA; MAP2K2; FLT3; Fasl; CSF1R
Colorectal cancer
PIK3R2; MAPK10; KRAS; MSH2; MAPK3; PIK3CA; TRP53; PIK3CG; CYCS; TGFBR1
Pancreatic cancer
RAF1; NFKB1; PIK3R5; CASP9; RALGDS; TGFBR1; SMAD3; SMAD2; CCND1; TP53
Endometrial cancer
RAF1; TP53; APC; KRAS; PIK3R5; TRP53; CASP9; FOXO3; NRAS; PIK3CA
Prostate cancer
BAD; CASP9; BCL2; INS2; MTOR; RELA; RAF1; PDGFB; PDPK1; FOXO1
Small cell lung cancer
LAMB3; APAF1; LAMB2; TRAF3; PIAS2; NFKB1; AKT2; CASP9; TRAF4; PIK3R3
Non-small cell lung cancer
PIK3R1; FHIT; BRAF; PIK3R2; RASSF5; MAPK1; NRAS; PIK3CA; PLCG1; RAF1
Viral myocarditis
HLA-DQB1; HLA-C; CD28; HLA-DMA; H2-AA; LAMA2; H2-Q10; ITGB2L; ACTB; SGCG

Protein Function

CASP9 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP9 itself. We selected most functions CASP9 had, and list some proteins which have the same functions with CASP9. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein FUT8; CASP9; DNM2; DOCK1; SHANK1; GRIK5; FAM125A; EPS15; HCLS1; ELMO1
Function cysteine-type endopeptidase activity
Related Protein USP42; Ctsl; USP27X; USP8; USP33; USP43; USP17L2; USP24; FMNL3; PDIA3
Function cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Related Protein CASP14; CASP8; CASP8L1; CFLAR; CASP10; CASP9; CFLARA; CASP2
Function enzyme activator activity
Related Protein PPP1R12B; RICTOR; CFLAR; OGT; DBF4; GMFB; LTC4S; GM749; DBNL; SFTPBB
Function peptidase activity
Related Protein C3orf37; AGBL4; DCD; CTSLL; ZMPSTE24; GM5077; PSMB9B; PARK7; MMP30; PRSS48
Function protein binding
Related Protein PAFAH1B1; MCC; DPEP3; CITED2; AP1B1; CCDC25; LDLRAP1; IFT46; RBMY1B; TRPV5
Function protein kinase binding
Related Protein LAT; RHEB; USF1; PEBP1; CCND3; ADRA2A; RAB11FIP2; FGF19; ACTA2; E2F1

Interacting Protein

CASP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP9.
XIAP; APAF1