ccnd1
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  • Official Full Name
  • cyclin D1
  • Background
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
  • Synonyms
  • CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene
Cat.#:CCND1-483HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 Protein, His-GST-tagged
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Cat.#:CCND1-0658HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCND1 Protein, GST-Tagged
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Cat.#:CDK4/CCND1-633HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK4/CCND1, His-tagged
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Cat.#:CCND1-171HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CCND1 protein, DDK-tagged
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Cat.#:CCND1-221HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, T7/His-tagged
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Cat.#:CCND1-23HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCND1 protein, MYC/DDK-tagged
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Cat.#:CCND1-24HTag:flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CCND1 protein, Flag-tagged
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Cat.#:CCND1-27520THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1, His-tagged
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Cat.#:CCND1-27756THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1
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Cat.#:CCND1-31773THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human CDK6, His-tagged
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Cat.#:CCND1-354HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, His/MBP-tagged
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Cat.#:CCND1-355HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, His/MBP-tagged
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Cat.#:IGLC1-14119HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGLC1, His-tagged
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Cat.#:Ccnd1-2610MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccnd1 protein, His-tagged
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Cat.#:CCND1-2988MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCND1 Protein
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Cat.#:CCND1-1219RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCND1 Protein
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Cat.#:Ccnd1-2611RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccnd1 protein, His-tagged
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Cat.#:CCND1-698RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCND1 Protein, His-tagged
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Cat.#:CCND1-2609CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CCND1 protein, His-tagged
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Cat.#:CCND1-6933CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCND1
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Cat.#:CCND1-8654ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCND1
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Cat.#:CCND1-2608CTag:His|T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CCND1 protein, His & T7-tagged
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Cat.#:CCND1-1444HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin D1, GST-tagged
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Cat.#:CCND1-7713HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CCND1 293 Cell Lysate
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Involved Pathway

CCND1 involved in several pathways and played different roles in them. We selected most pathways CCND1 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
MDM2; SMAD3; INSRB; PRKAG3B; PIK3CG; PRKAG2; FOXO6; MAPK12A; GADD45B; FBXO32
Cell cycle
EP300; KIF2C; LMNB1; MIS18A; CDC27; LIN54; CDC25B; TEX15; CDC14A; RBBP7
p signaling pathway
BBC3; CYCSB; CD82A; TP53AIP1; TRP53; BIDA; GADD45BA; SFN; EI24; TP53
PIK-Akt signaling pathway
CRTC2; RPTOR; ITGB8; PRL; SGK1; F2R; FGF13; FGF11; EPO; PPP2R5A
AMPK signaling pathway
PRKAB2; PRKAG2; ADIPOR1; FBP1; SCD; EEF2; EIF4EBP1; ADIPOQ; PPP2R1B; ADIPOR2
Wnt signaling pathway
PRKACG; CCND2A; PRKACB; CCND1; WNT10B; GSK3AA; PRICKLE1; CAMK2B1; EP300; FZD2
Hippo signaling pathway
TGFBR2; BIRC2; WNT2B; AXIN2; ACTG1; SMAD4; WNT4; PPP2CA; WWC1; WNT7B
Focal adhesion
ITGA8; PARVA; LAMA3; KDRL; TNW; CAPN2B; ROCK2A; DOCK1; RHOB; ITGB6
Jak-STAT signaling pathway
STAT1A; PRL; Gh; IL7; IL12BA; IL2RGA; IFNA17; IL24; JAK2A; IFNA2
Prolactin signaling pathway
ELF5; PIK3R1; KRAS; IRF1; FOS; PIK3R3; RELA; SOS1; LHCGR; PRP2
Thyroid hormone signaling pathway
ATP1B2; WNT4; TBC1D4; PLCE1; NOTCH2; PLCD1; DIO1; PLCZ1; PLCG1; MAP2K1
Oxytocin signaling pathway
PLCB3; PRKCB; CCND1; NFATC3; CALM4; FOS; MEF2C; PTGS2; PIK3CG; CAMKK2
Hepatitis B
IRF3; PIK3CD; IL-8; HBXIP; IRF7; IKBKE; CCNE1; OSTN; CASP12; NFATC1
Measles
IFNA6; TP73; IFNG; IL6; SH2D1A; RCHY1; MAVS; IL2RB; PIK3CD; TLR9
HTLV-I infection
BUB1B; XBP1; APC2; FZD8; CREM; MAP3K3; ATF1; IL6; SMAD3; CD40
Pathways in cancer
FIGF; PIAS2; MTOR; CBLB; FH; LPAR3; FZD7; HIF1A; SKP2; CBLC
Viral carcinogenesis
HDAC7; PIK3R1; UBE3A; TRAF3; HIST1H4M; HIST1H4G; HIST1H2BA; IKBKG; PIK3R5; HNRNPK
Proteoglycans in cancer
PIK3CB; FASLG; VTN; ACTB; RAF1; MAPK3; MAPK12; ANK1; CBLC; WNT3A
MicroRNAs in cancer
PDGFRB; TRIM71; SHC4; NRAS; MET; HDAC1; CDC25A; TRP63; PRKCG; RPS6KA5
Colorectal cancer
RAC1; PIK3CG; AKT2; PIK3R3; MSH3; BRAF; SMAD4; TCF7L2; TGFBR2; MLH1
Pancreatic cancer
VEGFA; KRAS; PIK3R3; PIK3CD; RAC1; TGFB2; TGFBR1; PIK3R5; PIK3CG; STAT1
Endometrial cancer
PIK3R2; GRB2; PDPK1; ELK1; CTNNA2; AXIN2; KRAS; RAF1; PTEN; TCF7L2
Glioma
PLCG2; PIK3R1; PDGFA; MTOR; PIK3CB; SHC1; PRKCG; PDGFRB; CAMK2G; PIK3R3
Prostate cancer
HSP90B1; EP300; CPN1; BCL2; SPRY1; NDRG1; AKT2; PIK3CG; MTOR; SMARCA4
Thyroid cancer
NTRK1; MAP2K1; PPARG; CDH1; TFG; TRP53; KRAS; MAPK3; LEF1; CCDC6
Melanoma
KRAS; FGF3; FGF8; FGF6; PDGFD; IGF1R; FGF20; PDGFB; HRAS; Pdgfa&Pdgfb
Bladder cancer
SRC; MAPK1; CCND1; CDH1; RPS6KA5; NRAS; BRAF; MYC; TP53; MMP9
Chronic myeloid leukemia
PIK3CD; IKBKG; PIK3CA; NRAS; CDK6; TGFB1; PIK3CG; BCR; TP53; MAP2K2
Acute myeloid leukemia
RUNX1; AKT1; AKT3; SPI1; NRAS; CEBPA; PIK3R2; HRAS; IKBKG; PIK3CG
Small cell lung cancer
LAMB3; TRAF5; SKP2; IKBKB; ITGA3; TP53; PIK3R2; LAMC2; PIK3R1; RXRG
Non-small cell lung cancer
BRAF; PRKCA; PIK3CD; PIK3CB; SOS1; TP53; PIK3R1; HRAS; RARB; KRAS
Viral myocarditis
HLA-DOB; CD86; HLA-A; EIF4G2; ITGAL; CXADR; RAC2; MYH7; HLA-DQA2; SGCD

Protein Function

CCND1 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND1 itself. We selected most functions CCND1 had, and list some proteins which have the same functions with CCND1. You can find most of the proteins on our site.
Function
Related Protein
Function cyclin-dependent protein serine/threonine kinase regulator activity
Related Protein CCNY; CKS1B; CCNL1A; CCND1; CKS2; CCNL1B; CCNT2B; CCNT2A; CCNE2; CCNC
Function enzyme binding
Related Protein GOLPH3; PRMT1; PLSCR1; DDX5; DNMT3L; NLRP1; Slc4a2; RCOR2; PYCARD; ESR2
Function histone deacetylase binding
Related Protein RELA; MAGEA2B; NACC2; NRIP1; DDX20; ANKRA2; HIF1A; CEBPB; RUNX2; NCOR2
Function proline-rich region binding
Related Protein GAREM; GHR; RABAC1; FAM59A; BAIAP2; WBP4; ABL1; BAIAP2L1; PRPF40A; ABI2
Function protein binding
Related Protein HOXA3; MARK2; MLKL; GLDN; TM4SF4; MAGEB6; SEPT2; HDHD3; ARF5; RBM6
Function protein complex binding
Related Protein VAMP2; PPP1R9B; SKAP1; YWHAB; RAP1A; NCK2; LCK; CYFIP1; RBX1; COG2
Function protein kinase activity
Related Protein EK1; TEK; CHUK; SBK3; RAF1; PRKACAA; NRBP1; OXSR1A; MAP2K4; BRAF
Function protein kinase binding
Related Protein RPTOR; AKAP1; SCN5A; STAT3; STK39; GDF3; ADAM10; CCNA2; HNRNPA0; CDH2
Function transcription corepressor activity
Related Protein FEV; FOXP3; WTIP; APEX1; AJUBA; YAP1; NR0B2; DRAP1; ALX1; SKOR1B
Function transcription factor binding
Related Protein DIP2C; E2F2; STK36; SRY; SUMO1; KAT6B; YWHAZ; FOXO4; SOX17; MED1

Interacting Protein

CCND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND1.
CDK4; CDKN1A

CCND1 Related Articles

Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).