CD1D
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Official Full Name
CD1d molecule
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Overview
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related;to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1;proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells.;The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are;thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by;this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. -
Synonyms
CD1D; CD1d molecule; CD1d antigen , CD1D antigen, d polypeptide; antigen-presenting glycoprotein CD1d; R3G1; thymocyte antigen CD1D; CD1D antigen, d polypeptide; T-cell surface glycoprotein CD1d; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; R3; CD1A; MGC34622;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Ovis aries (Sheep)
- Rabbit
- Rhesus Macaque
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- His (Fc)
- Avi
- SUMO
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CD1D & B2M-250H | Recombinant Human CD1D & B2M protein, His-tagged | HEK293 | His | Met1-Ser301 & Met1-Met119 | |
Human | CD1D-27107TH | Recombinant Human CD1D | Wheat Germ | N/A | 335 amino acids | |
Human | CD1D-2188H | Recombinant Human CD1D, His tagged | Human Cell | His | ||
Human | CD1D-828H | Recombinant Human CD1D Protein, Fc-tagged | HEK293 | Fc | ||
Human | CD1D-10920H | Recombinant Human CD1D, His-tagged | E.coli | His | 18-302a.a. | |
Human | CD1D & B2M-001HCL | Recombinant Human CD1D & B2M cell lysate | Human Cell | N/A | ||
Human | CD1D-2479HCL | Recombinant Human CD1D cell lysate | Human Cell | N/A | ||
Human | CD1D-166H | Recombinant Human CD1D Protein, C-His-tagged | E.coli | C-His | ||
Human | CD1D-5279H | Recombinant Human CD1D Protein (Met1-Ser301), C-His tagged | Mammalian cells | C-His | Met1-Ser301 | |
Human | CD1D-231H | Recombinant Human CD1D Protein, His-tagged | Insect Cell | His | 20-301aa | |
Human | CD1D-2659H | Recombinant Human CD1D protein, His-SUMO-tagged | E.coli | His-SUMO | 20-301aa | |
Human | CD1D-151H | Recombinant Human CD1D Protein, His-tagged | Human Cells | His | ||
Human | CD1D-64HF | Recombinant Full Length Human CD1D Protein | In Vitro Cell Free System | 335 amino acids | ||
Human | CD1d-0916H | Recombinant Human CD1d Protein (Glu20-Ser301), N-His tagged | E.coli | N-His | Glu20-Ser301 | |
Rabbit | CD1D-3515S | Recombinant Sylvilagus floridanus (Cottontail rabbit) CD1D, His-tagged | E.Coli or Yeast | His | 275 | |
Homo sapiens (Human) | RFL31371HF | Recombinant Full Length Human Antigen-Presenting Glycoprotein Cd1D(Cd1D) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (20-335) | |
Ovis aries (Sheep) | RFL4802OF | Recombinant Full Length Sheep Antigen-Presenting Glycoprotein Cd1D(Cd1D) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (18-335) | |
Rhesus Macaque | CD1D-723R | Recombinant Rhesus monkey CD1D Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | CD1D-550R-B | Recombinant Rhesus Macaque CD1D Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | CD1D-550R | Recombinant Rhesus Macaque CD1D Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- CD1D Related Articles
- CD1D Related Research Area
CD1D involved in several pathways and played different roles in them. We selected most pathways CD1D participated on our site, such as Hematopoietic cell lineage, Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hematopoietic cell lineage | IL5;ITGA2B;IL3;TNF;IL11RA;IL11RA2;ITGB3;CSF1R;IL3RA |
Amoebiasis | PIK3CD;IL10;PIK3R5;LAMA3;PLCB3;CD1D;LAMA1;LAMC3;Itgam&Itgb2 |
CD1D has several biochemical functions, for example, beta-2-microglobulin binding, cell adhesion molecule binding, endogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1D itself. We selected most functions CD1D had, and list some proteins which have the same functions with CD1D. You can find most of the proteins on our site.
Function | Related Protein |
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beta-2-microglobulin binding | H2-Q10;CD1B;HLA-E;CD1C;CD1D;CD1A;CD1D2;HFE;FCGRT |
cell adhesion molecule binding | NRXN3;CD226;PVR;PVRL2L;MSN;SMAGP;NLGN4X;CADM1A;CADM2 |
endogenous lipid antigen binding | CD1E;CD1B;CD1d1;CD1C;CD1D;CD1D2;CD1A |
exogenous lipid antigen binding | CD1A;CD1d1;CD1B;CD1D;CD1E;CD1D2;CD1C |
histone binding | Ctsl;L3MBTL1;HIST1H4D;SART3;UHRF1;MCM2;PRKCB;BRD7;ASF1B |
lipid antigen binding | CD1D;CD1d1 |
lipopeptide binding | TLR6;CD1C;CD1D;CD1D2;CD1E;CD1d1;CD1B;CD1A |
receptor activity | NOTCH1A;PVRL1B;NOTCH2;RNF139;VMN1R48;NLGN1;CADM3;VMN1R52;NRXN1 |
CD1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1D here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1D.
- Q&As
- Reviews
Q&As (5)
Ask a questionSome pharmaceutical companies are researching and developing drugs that target CD1D for therapeutic purposes, although these are still in the early stages of development.
CD1D binds and presents lipid antigens to NKT cells, facilitating immune responses against pathogens or aberrant cells.
CD1D primarily presents lipid antigens, while major histocompatibility complex (MHC) proteins present peptide antigens. CD1D is crucial for lipid-specific immune responses.
CD1D deficiency has been associated with an increased susceptibility to certain infections and a potential link to autoimmune disorders.
Yes, several clinical trials are exploring the modulation of CD1D in various diseases, including cancer and autoimmune disorders, to assess its therapeutic potential.
Customer Reviews (3)
Write a reviewThe CD1D protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.
Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.
In protein electron microscopy structure analysis, the CD1D protein demonstrates outstanding performance.
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