|Official Full Name||CD209 molecule|
|Background||This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]|
|Synonyms||CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CD209 involved in several pathways and played different roles in them. We selected most pathways CD209 participated on our site, such as Phagosome, Tuberculosis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD209 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phagosome||MHC2DEB; TLR2; MHC1UEA; FCGR3B; Pla2r1; HLA-DOB; ATP6V1H; MHC1UXA2; TUBA2; CTSSA|
|Tuberculosis||IL1B; NOS2; HSPA9; IFNA2; MAPK9; IL18; HLA-DMB; ATP6V1H; VDR; CAMK2A|
|Measles||IFNA21; FAS; DOK1; IFNA7; CD209C; STAT5A; MAVS; AKT1; RAB9A; TLR2|
CD209 has several biochemical functions, for example, carbohydrate binding, mannose binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD209 itself. We selected most functions CD209 had, and list some proteins which have the same functions with CD209. You can find most of the proteins on our site.
|carbohydrate binding||LMAN1L; CHI3L2; ZG16B; MAN2C1; OLR1; Siglece; KLRF1; MBL1; MAN2A2; LY75|
|mannose binding||CD209B; MANBA; LMAN2; IGF2R; BSG; CD209A; Acr; CD207; CD209C; CLN5|
|metal ion binding||MUTYH; MAT1A; ZBTB11; ZNF691; ZNF839; ZNF480; SKINT8; MFNG; AMDHD2; RNF44|
|peptide antigen binding||AZGP1; MHC1UFA; HLA-DQA1; MHC1ZFA; MHC1ZKA; HLA-DRB4; H2-AA; MHC1UEA; DHCR24; TUBB3|
|protein binding||C4BPA; NOTCH1; GSDMA2; RPS11; PTRH1; HHIP; HIPK4; CDK5R1; KIAA1967; POC1A|
|virion binding||PVRL1; HSP90B1; HIPK2; CD209; PTX3; TSG101; PPIA; APCS; CLEC4M|
|virus receptor activity||ACE2; CD86; ITGB3; AXL; CLDN1; SLC10A1; HYAL2; ITGA2; SIVA1; SCARB2|
CD209 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD209 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD209.