cd209
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  • Official Full Name
  • CD209 molecule
  • Background
  • This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
  • Synonyms
  • CD209; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin;
Cat.#:CD209-0747HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD209 Protein
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Cat.#:CD209-0748HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD209 Protein, GST-Tagged
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Cat.#:CD209-633HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD209, Fc tagged
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Cat.#:CD209-634HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD209 protein, Fc-tagged
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Cat.#:CD209-635HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD209 protein
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Cat.#:CD209-636HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human CD209 protein, Fc-tagged
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Cat.#:CD209-7173HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD209 protein, His & T7-tagged
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Cat.#:CD209-727RTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus CD209 protein, His-tagged
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Cat.#:CD209-728RTag:Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus CD209 protein, Fc-tagged
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Cat.#:CD209-7858ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD209
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Cat.#:CD209-2986HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD209 cell lysate
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Involved Pathway

CD209 involved in several pathways and played different roles in them. We selected most pathways CD209 participated on our site, such as Phagosome, Tuberculosis, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD209 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
HBL4; THBS4A; HLA-DPA1; HLA-DRB5; TUBA3B; HLA-DRB3; TUBA8; TUBA8L3; CD36; SEC22B
Tuberculosis
SPHK2; TLR9; MAPK12; IRAK4; LBP; CLEC4M; HSPD1; RAB7; BCL2; FCGR3A
Measles
HSPA1L; CD3G; STAT5B; IFNGR2; IL1B; EIF2AK2; TLR4; IFNA5; TAB2; DOK1

Protein Function

CD209 has several biochemical functions, for example, carbohydrate binding, mannose binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD209 itself. We selected most functions CD209 had, and list some proteins which have the same functions with CD209. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein CLEC4F; ATRN; MLEC; CD34; PRG2; CLEC3A; Siglece; LGALS3L; CD72; FBXO6
Function mannose binding
Related Protein DPM1; CD207; Acr; LMAN1; CD209B; CD209A; COLEC10; MANBA; M6PR; MBL2
Function metal ion binding
Related Protein SPON2; ZNF71; ZNF23; ZNF187; PRDM13; TNK2; ZXDC; AKAP13; DGKD; GATA5
Function peptide antigen binding
Related Protein HLA-G; TUBB3; MHC1UFA; HLA-DRB3; HLA-C; HLA-DRB5; MHC1UHA; MHC1ZHA; MHC1ZE; MHC1UBA
Function protein binding
Related Protein CASP1; TLX2; LRRC8C; CCDC170; ZNF404; SF3B3; TMED2; LINGO1B; TAF7L; YWHAB
Function virion binding
Related Protein CLEC4M; APCS; CD209; PTX3; PPIA; PVRL1; TSG101; HIPK2; HSP90B1
Function virus receptor activity
Related Protein ITGB5; CLEC5A; SERPINB3; HLA-DRB1; MRC1; CR1; SLC20A2; CCR5; GYPA; CD46

Interacting Protein

CD209 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD209 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD209.
VAC14; q03463-pro_0000278734

CD209 Related Articles

Park, KT; Burnett, S; et al. Development and characterization of a monoclonal antibody specific for bovine CD209. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:216-220(2015).
Paul, M; Reljic, R; et al. Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV. MABS 6:1585-1597(2014).