CD48

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CD48

Official Full Name CD48 CD48 molecule
Background CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for 2B4. CD482B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk.The absence of functional 2B4 CD48 interactions impairs NK cell cytotoxic response and IFN-release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by a 2B4CD48-dependent mechanism.
Synonyms CD48; CD48 molecule; BCM1, CD48 antigen (B cell membrane protein) , CD48 molecule; CD48 antigen; BLAST; hCD48; mCD48; SLAMF2; TCT.1; BCM1 surface antigen; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); BCM1; BLAST1; MEM-102
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Rabbit
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • T7
    • human
    • IgG1
    • Mouse
    • IgG2a
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD48-2042H Recombinant Human CD48 Protein, Fc/His-tagged HEK293 Fc/His
    Human CD48-204HG GMP Recombinant Human CD48 protein, His-tagged HEK293 His
    Human CD48-357H Recombinant Human CD48 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human CAB11502RH Rabbit Anti-Human CD48 Molecule Monoclonal Antibody Rabbit N/A
    Human CD48-0828H Recombinant Human CD48 Protein, GST-Tagged Wheat Germ GST
    Human CD48-10960H Recombinant Human CD48, GST-tagged E.coli GST
    Human CD48-1871H Recombinant Human CD48 protein, His & T7-tagged E.coli His/T7
    Human CD48-234H Recombinant Human CD48 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD48-252H Recombinant Human CD48, Fc-tagged Human Cell Fc
    Human CD48-26635TH Recombinant Human CD48 Wheat Germ N/A
    Human CD48-3044HCL Recombinant Human CD48 cell lysate Human Cell N/A
    Human CD48-654H Recombinant Human CD48 protein, His-tagged HEK293 His
    Human CD48-680H Recombinant Human CD48, Fc-tagged, Biotinylated Human Cell Fc
    Human CD48-719H Recombinant Human CD48 Protein CHO N/A
    Human CD48-838H Recombinant Human CD48 Protein, Fc/His-tagged HEK293 Fc/His
    Mouse Cd48-1872M Recombinant Mouse Cd48 protein, His & T7-tagged E.coli His/T7
    Mouse CD48-2468MCL Recombinant Mouse CD48 cell lysate Human Cell N/A
    Mouse Cd48-3293M Recombinant Mouse CD48 Antigen, His-tagged Human Cell His
    Mouse Cd48-459M Recombinant Mouse Cd48, His-tagged NS0 His
    Mouse Cd48-486M Recombinant Mouse Cd48, Fc-tagged Human Cell Fc
    Mouse CD48-720M Recombinant Mouse CD48 Protein CHO N/A
    Mouse CD48-867M Recombinant Mouse CD48 Protein, His-tagged HEK293 His
    Rat CD48-1256R Recombinant Rat CD48 Protein Mammalian Cell His
    Rat CD48-1258RCL Recombinant Rat CD48 cell lysate Human Cell N/A
    Rat Cd48-1873R Recombinant Rat Cd48 protein, His & T7-tagged E.coli His/T7
    Rat Cd48-8762R Recombinant Rat Cd48, Fc tagged Human Cell Fc
    Rat Cd48-8763R Recombinant Rat Cd48, His tagged Human Cell His

    CD48 involved in several pathways and played different roles in them. We selected most pathways CD48 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD48 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity ARAF; SOS1; PIK3CB; PRF1; RAET1E; SAMD3; VAV2; IFNAR1; PPP3CA; KIR2DS3

    CD48 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD48 itself. We selected most functions CD48 had, and list some proteins which have the same functions with CD48. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RAB7L1; RWDD1; AIG1; FMR1; FEM1B; HSPBAP1; PCID2; BRD7; MBL2; C11orf67

    CD48 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD48 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD48.

    CD244; EEF1D; yapA; BXDC2

    Meazza, R; Tuberosa, C; et al. XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1526-1534(2014).
    Hashmi, FK; Cail, R; et al. Adaptation of WM-68 Hybridoma Cell-line in Minimal Serum and Serum Free Culture Conditions. PAKISTAN JOURNAL OF ZOOLOGY 46:355-362(2014).

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