cd48
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  • Official Full Name
  • CD48 CD48 molecule
  • Background
  • CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for 2B4. CD482B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk.The absence of functional 2B4 CD48 interactions impairs NK cell cytotoxic response and IFN-release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by a 2B4CD48-dependent mechanism.
  • Synonyms
  • CD48; CD48 molecule; BCM1, CD48 antigen (B cell membrane protein) , CD48 molecule; CD48 antigen; BLAST; hCD48; mCD48; SLAMF2; TCT.1; BCM1 surface antigen; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); BCM1; BLAST1; MEM-102
Cat.#:CD48-2042HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD48 Protein, Fc/His-tagged
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Cat.#:CD48-357HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD48 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:CD48-0828HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD48 Protein, GST-Tagged
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Cat.#:CD48-719HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD48 Protein
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Cat.#:CD48-720MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse CD48 Protein
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Cat.#:Cd48-3293MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD48 Antigen, His-tagged
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Cat.#:CD48-10960HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD48, GST-tagged
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Cat.#:CD48-1871HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD48 protein, His & T7-tagged
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Cat.#:CD48-234HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD48 protein, Fc-tagged
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Cat.#:CD48-252HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD48, Fc-tagged
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Cat.#:CD48-26635THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD48
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Cat.#:CD48-654HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD48, His tagged
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Cat.#:CD48-680HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD48, Fc-tagged, Biotinylated
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Cat.#:CD48-838HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CD48 Protein, Fc/His-tagged
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Cat.#:Cd48-1872MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd48 protein, His & T7-tagged
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Cat.#:Cd48-459MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Cd48, His-tagged
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Cat.#:Cd48-486MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd48, Fc-tagged
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Cat.#:CD48-867MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD48 Protein, His-tagged
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Cat.#:CD48-1256RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD48 Protein
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Cat.#:Cd48-1873RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd48 protein, His & T7-tagged
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Cat.#:Cd48-8762RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd48, Fc tagged
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Cat.#:Cd48-8763RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd48, His tagged
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Cat.#:CD48-3044HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD48 cell lysate
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Cat.#:CD48-2468MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD48 cell lysate
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Cat.#:CD48-1258RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD48 cell lysate
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Involved Pathway

CD48 involved in several pathways and played different roles in them. We selected most pathways CD48 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD48 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Natural killer cell mediated cytotoxicity
SHC4; HLA-G; IFNA4; FCGR4; VAV2; RAET1L; KLRA8; Raet1a; ITGB2; KLRD1

Protein Function

CD48 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD48 itself. We selected most functions CD48 had, and list some proteins which have the same functions with CD48. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CHMP4A; SOST; ALPI; KRT16; TUFT1; MEX3C; LNX1; NDUFS3; CXCR2; RPL30

Interacting Protein

CD48 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD48 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD48.
CD244; EEF1D; yapA; BXDC2

CD48 Related Articles

Meazza, R; Tuberosa, C; et al. XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1526-1534(2014).
Hashmi, FK; Cail, R; et al. Adaptation of WM-68 Hybridoma Cell-line in Minimal Serum and Serum Free Culture Conditions. PAKISTAN JOURNAL OF ZOOLOGY 46:355-362(2014).

CD48 Related Gene Family

Immunoglobulins