CFL1 Protein, cofilin 1 (non-muscle)


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Official Full Name cofilin 1 (non-muscle)
Background The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Synonyms CFL1; cofilin 1 (non-muscle); CFL; HEL-S-15; cofilin-1; p18; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CFL1-1172H Recombinant Human CFL1 Protein, GST-Tagged Wheat Germ GST
    Human CFL1-1580H Recombinant Human Cofilin 1 (non-muscle), His-tagged E.coli His
    Human CFL1-2374H Recombinant Human Cofilin 1 (Non-muscle), GST-tagged E.coli GST
    Human CFL1-26778TH Recombinant Human CFL1 N/A
    Human CFL1-26781TH Recombinant Human CFL1 E.coli N/A
    Human CFL1-26844TH Recombinant Human CFL1, His-tagged E.coli His
    Human CFL1-366H Recombinant Human CFL1, His tagged E.coli Fc
    Human CFL1-7555HCL Recombinant Human CFL1 293 Cell Lysate HEK293 N/A
    Mouse CFL1-3350M Recombinant Mouse CFL1 Protein Mammalian Cell His
    Mouse Cfl1-870M Recombinant Mouse Cfl1 Protein, GST-tagged E.coli GST
    Rat CFL1-1356R Recombinant Rat CFL1 Protein Mammalian Cell His
    Rhesus Macaque CFL1-828R Recombinant Rhesus monkey CFL1 Protein, His-tagged Mammalian Cell His
    Zebrafish CFL1-12705Z Recombinant Zebrafish CFL1 Mammalian Cell His

    CFL1 involved in several pathways and played different roles in them. We selected most pathways CFL1 participated on our site, such as Axon guidance, BDNF signaling pathway, CDC42 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance LRRC4; NRP1A; CLTB; FRS3; MET; SEMA6B; CXCR4; FGF20A; SEMA4A; NCK1
    BDNF signaling pathway FRS3; EEF2; JAK2; GRIP1; CNR1; CFL1; CSNK2A1P; LINGO1; SYN1; CDH2
    CDC42 signaling events ACTR2; ARPC1B; ARPC5; ARPC4; TNK2; ACTR3; ARPC2; ARPC3; BAIAP2; EPS8
    CXCR4-mediated signaling events CFL1; BLK; DNM1; CSK; JAK2; ARR3; MAPKAP1; GNA13; CRK; PAG1
    Developmental Biology CACNG2B; NR2F2; FOXH1; EPHB3A; MED26; AP2A2; EBF1; RGMB; CNTN1; COL4A4
    EPH-Ephrin signaling ARPC1B; ARPC5; EFNB1; AP2B1; EFNA3B; AP2S1; EPHA2A; EFNA2; ACTR2B; CLTB
    EPHB-mediated forward signaling ACTR2B; EFNB2; EFNB2A; EFNB3B; EPHB3A; EFNB3; CFL1; ARPC5; KALRNB; EPHB4A
    Fc gamma R-mediated phagocytosis WASF1; PPAP2A; PPAP2C; PLA2G4A; PRKCA; PIK3CB; PLD2; MAP2K1; ASAP1; RAF1

    CFL1 has several biochemical functions, for example, actin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFL1 itself. We selected most functions CFL1 had, and list some proteins which have the same functions with CFL1. You can find most of the proteins on our site.

    Function Related Protein
    actin binding CAPZA2; CALD1B; MYH11A; ARPC5L; HIP1R; CAPGB; WASLA; C19orf21; ABLIM2; MSRB1A
    protein binding SCG2; PPP1R12C; SSNA1; HMGCR; TDRKH; FAM117B; RABGGTB; SYNE1; UQCRC2; Trf

    CFL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFL1.


    Nakashima, J; Laosinchai, W; et al. New insight into the mechanism of cellulose and callose biosynthesis: proteases may regulate callose biosynthesis upon wounding. CELLULOSE 10:369-389(2003).
    Cui, XJ; Shin, HS; et al. A putative plant homolog of the yeast beta-1,3-glucan synthase subunit FKS1 from cotton (Gossypium hirsutum L.) fibers. PLANTA 213:223-230(2001).

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