Recombinant Human CFL1, His-tagged

• Cat.No.: CFL1-11142H
• Product Overview: Recombinant Human CFL1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-166a.a.
• Description: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
• Source: E.coli
• Species: Human
• Tag: His
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CFL1 cofilin 1 (non-muscle) [ Homo sapiens ]
• Official Symbol: CFL1
• Synonyms: CFL1; cofilin 1 (non-muscle); CFL; cofilin-1; p18; 18 kDa phosphoprotein; cofilin, non-muscle isoform
• Gene ID: 1072
• mRNA Refseq: NM_005507
• Protein Refseq: NP_005498
• MIM: 601442
• UniProt ID: P23528
• Chromosome Location: 11q13.1
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem
• Function: actin binding; protein binding