CHGA
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Official Full Name
chromogranin A (parathyroid secretory protein 1) -
Overview
Pancreastatin belongs to the chromogranin/secretogranin protein family, strongly inhibits glucose induced insulin release from the pancreas. The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. -
Synonyms
CHGA;chromogranin A (parathyroid secretory protein 1);chromogranin-A;SP-I;pituitary secretory protein I;parathyroid secretory protein 1;betagranin (N-terminal fragment of chromogranin A);CGA;CgA;Pancreastatin
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Pig
- Rhesus macaque
- E.coli
- Human
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- Insect cells
- In Vitro Cell Free System
- GST
- His
- Non
- T7
- DDK
- Myc
- Flag
- Avi
- Fc
Involved Pathway
CHGA involved in several pathways and played different roles in them. We selected most pathways CHGA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CHGA has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CHGA itself. We selected most functions CHGA had, and list some proteins which have the same functions with CHGA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CHGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHGA here. Most of them are supplied by our site. Hope this information will be useful for your research of CHGA.
PFDN1;NEK2;CDC37
Resources
Research Area
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References
- Gottlieb, PA; Delong, T; et al. Chromogranin A is a T cell antigen in human type 1 diabetes. JOURNAL OF AUTOIMMUNITY 50:38-41(2014).
- Nikoopour, E; Cheung, R; et al. Vasostatin-1 antigenic epitope mapping for induction of cellular and humoral immune responses to chromogranin A autoantigen in NOD mice. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1170-1180(2014).
