Recombinant Human CHGA Protein (19-457 aa), His-tagged

• Cat.No.: CHGA-1360H
• Product Overview: Recombinant Human CHGA Protein (19-457 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length of Mature Protein.

Specification

• Description: Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist . Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chokines . Acts as a potent scavenger of free radicals in vitro . May play a role in the regulation of cardiac function and blood pressure.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 50.9 kDa
• Protein length: 19-457 aa
• AA Sequence: LPVNSPMNKGDTEVMKCIVEVISDT LSKPSPMPVSQECFETLRGDERILS ILRHQNLLKELQDLALQGAKERAHQ QKKHSGFEDELSEVLENQSSQAELK EAVEEPSSKDVMEKREDSKEAEKSG EATDGARPQALPEPMQESKAEGNNQ APGEEEEEEEEATNTHPPASLPSQK YPGPQAEGDSEGLSQGLVDREKGLS AEPGWQAKREEEEEEEEEAEAGEEA VPEEEGPTVVLNPHPSLGYKEIRKG ESRSEALAVDGAGKPGAEEAQDPEG KGEQEHSQQKEEEEEMAVVPQGLFR GGKSGELEQEEERLSKEWEDSKRWS KMDQLAKELTAEKRLEGQEEEEDNR DSSMKLSFRARAYGFRGPGPQLRRG WRPSSREDSLEAGLPLQVRGYPEEK KEEEGSANRRPEDQELESLSAIEAE LEKVAHQLQALRRG
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: CHGA chromogranin A (parathyroid secretory protein 1) [ Homo sapiens ]
• Official Symbol: CHGA
• Synonyms: CHGA; pancreastatin; parastatin; vasostatin; SP-I; CGA
• Gene ID: 1113
• mRNA Refseq: NM_001275
• Protein Refseq: NP_001266
• MIM: 118910
• UniProt ID: P10645