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CLK1

  • Official Full Name

    CDC-like kinase 1

  • Overview

    This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CLK1; CDC-like kinase 1; dual specificity protein kinase CLK1; STY; CDC like kinase 1; CLK; CLK/STY; CLK1_HUMAN; OTTHUMP00000163673; OTTHUMP00000206165; OTTHUMP00000206166; CDC28/CDC2-like kinase; protein tyrosine kinase STY;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLK1-676H Recombinant Human CDC-like Kinase 1, GST-tagged E.coli GST
Human CLK1-1491H Recombinant Human CLK1 Protein, GST-tagged Wheat Germ GST
Human CLK1-27274TH Recombinant Human CLK1 Wheat Germ N/A 484 amino acids
Human CLK1-284H Recombinant Human CDC-like Kinase 1, GST-tagged, Active Sf9 Insect Cell GST
Human CLK1-1490H Active Recombinant Human CLK1 Protein, GST-His-tagged Insect Cell GST/His
Human CLK1-567H Recombinant Human CLK1 Mammalian Cell His
Human CLK1-7441HCL Recombinant Human CLK1 293 Cell Lysate HEK293 N/A
Human CLK1-88HF Recombinant Full Length Human CLK1 Protein In Vitro Cell Free System 484 amino acids
Human CLK1-2688H Recombinant Human CLK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLK1-2203HF Recombinant Full Length Human CLK1 Protein, GST-tagged In Vitro Cell Free System GST 484 amino acids
Human CLK1-2688H-B Recombinant Human CLK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CLK1-3585M Recombinant Mouse CLK1 Protein Mammalian Cell His
Mouse CLK1-1759M-B Recombinant Mouse CLK1 Protein Pre-coupled Magnetic Beads HEK293
Mouse CLK1-1759M Recombinant Mouse CLK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CLK1-912R Recombinant Rhesus monkey CLK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLK1-737R Recombinant Rhesus Macaque CLK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CLK1-737R-B Recombinant Rhesus Macaque CLK1 Protein Pre-coupled Magnetic Beads HEK293
Kit-1571 CLK1 Kinase Binding Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CLK1 involved in several pathways and played different roles in them. We selected most pathways CLK1 participated on our site, such as Legionellosis, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LegionellosisCASP9;EEF1G;SAR1B;IL-8;BCL2L13;HSPA1B;SEC22B;CXCL2;IL12A
mRNA processingADAM5;RNASET2B;PTBP1A;ZFP740;SRSF10;ZFP622;PRPF8;VPRBP;TXNL4A

CLK1 has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK1 itself. We selected most functions CLK1 had, and list some proteins which have the same functions with CLK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRENBP;QARS;SUCLA2;ADCY1;HSPD1;UBE2U;RECQL;MYO18A;RYK
non-membrane spanning protein tyrosine kinase activityPTK2AB;WEE1;FES;TNK2B;FER;PKDCC;PRKCD;FYNB;TXK
protein bindingEVI5;HTR3A;ALG13;PRMT2;OBSCN;JUN;RBM41;FBL;RIBC2
protein serine/threonine kinase activityMAP3K12;DCLK1;PRKY;TAOK3;DCAMKL2;LIMK2;GAK;IKBKB;NEK3
protein serine/threonine/tyrosine kinase activityACVR2B;SGK1;DYRK4;TESK1;DYRK1AA;TESK2;DYRK1B;PRKCG;DYRK3

CLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK1.

PDE9A; KRTAP10-7; PTPN1; N/A; SRPK2; SRPK1; PSEN2; YWHAG; PRMT5; ltp_ebvg; ezrA; PIAS4; GOLM1; q8xa11_eco57; DOCK9

  • Q&As
  • Reviews

Q&As (5)

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How is CLK1 expression regulated in normal physiological conditions? 10/18/2020

CLK1 expression is tightly regulated at transcriptional and post-translational levels, ensuring its proper function in normal cellular processes.

How is CLK1 activity measured in research settings? 06/09/2020

Researchers often measure CLK1 activity through in vitro kinase assays or by monitoring its phosphorylation targets in cellular or tissue samples.

Can targeting CLK1 have implications for neurodegenerative diseases? 06/09/2018

Yes, studies suggest that CLK1 inhibitors may have therapeutic potential for neurodegenerative disorders by modulating RNA splicing.

Are there any known CLK1 mutations associated with diseases? 09/16/2017

Some studies suggest that CLK1 mutations may be associated with certain diseases, but further research is needed to establish clear links.

Are there any CLK1 inhibitors under development for cancer treatment? 01/21/2016

Yes, several CLK1 inhibitors are in preclinical and clinical development as potential anticancer agents.

Customer Reviews (3)

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Reviews
01/31/2021

    The manufacturer's commitment to customer satisfaction extends beyond technical support. They offer a comprehensive range of related products and resources to aid researchers in their trials.

    01/22/2019

      From troubleshooting to optimizing experimental protocols, the manufacturer provides diligent support to ensure the success of the trial.

      09/28/2018

        The CLK1 protein offers several advantageous features that make it an ideal choice for researchers conducting trials.

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