clk1
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  • Official Full Name
  • CDC-like kinase 1
  • Background
  • This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CLK1; CDC-like kinase 1; dual specificity protein kinase CLK1; STY; CDC like kinase 1; CLK; CLK/STY; CLK1_HUMAN; OTTHUMP00000163673; OTTHUMP00000206165; OTTHUMP00000206166; CDC28/CDC2-like kinase; protein tyrosine kinase STY
Cat.#:CLK1-1490HTag:GST/His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human CLK1 Protein, GST-His-tagged
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Cat.#:CLK1-1491HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLK1 Protein, GST-tagged
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Cat.#:CLK1-27274THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CLK1
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Cat.#:CLK1-284HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDC-like Kinase 1, GST-tagged, Active
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Cat.#:CLK1-567HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CLK1
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Cat.#:CLK1-676HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC-like Kinase 1, GST-tagged
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Cat.#:CLK1-3585MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLK1 Protein
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Cat.#:CLK1-912RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CLK1 Protein, His-tagged
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Cat.#:CLK1-7441HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CLK1 293 Cell Lysate
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Cat.#:Kit-1571Tag:
Source (Host):Species:
Product nameCLK1 Kinase Binding Assay Kit
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Involved Pathway

CLK1 involved in several pathways and played different roles in them. We selected most pathways CLK1 participated on our site, such as Legionellosis, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Legionellosis
HSPA1A; BNIP3; HSF1; CASP7; NFKB1; NLRC4; EEF1A2; HSPA1B; C3; RAB1
mRNA processing
CELF2; RBM39A; PRPF8; RAVER1; EIF4E3; HNRNPL; ADARB2; DDX39; SFRS3A; CELF4

Protein Function

CLK1 has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK1 itself. We selected most functions CLK1 had, and list some proteins which have the same functions with CLK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PANK3; DDX39; DHX9; MTOR; ITK; NLRC5; ACVR1; ABCA9; CKBA; ACSBG2
Function non-membrane spanning protein tyrosine kinase activity
Related Protein FYN; BMX; WEE2; DYRK1A; PTK2B; TNK1; FRK; FYNB; BTK; STK16
Function protein binding
Related Protein EFNA4; TSC22D4; CASP9; KRTAP12-2; TARDBP; TEX14; OTULIN; TACR3; BCR; TBX18
Function protein serine/threonine kinase activity
Related Protein MAPK1; PRKY; TAOK2; PRKCD; NEK6; NEK1; LRRK1; CSNK1A1L; ACVR1L; STK11
Function protein serine/threonine/tyrosine kinase activity
Related Protein CLK1; AKT1; TESK1; RPS6KA1; AURKB; PRKAA2; DYRK1B; TESK2; CLK3; MAP2K2

Interacting Protein

CLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK1.
PDE9A; KRTAP10-7; PTPN1; N/A; SRPK2; SRPK1; PSEN2; YWHAG; PRMT5; ltp_ebvg; ezrA; PIAS4; GOLM1; q8xa11_eco57; DOCK9