ctgf
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  • Official Full Name
  • connective tissue growth factor
  • Background
  • The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
  • Synonyms
  • CTGF; connective tissue growth factor; CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8;
Cat.#:CTGF-2604HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTGF Protein, His-Avi-tagged, Biotinylated
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Cat.#:CTGF-391HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTGF Protein, His & Avi-tagged, Unconjugated
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Cat.#:CTGF-392HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTGF Protein (Gln 27 - Ala 349), His-tagged
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Cat.#:CTGF-393MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CTGF Protein, His-tagged
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Cat.#:CTGF-2069HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTGF Protein, GST-tagged
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Cat.#:CTGF-555HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Connective Tissue Growth Factor
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Cat.#:CTGF-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTGF, His-tagged
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Cat.#:CTGF-2605HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTGF, His-tagged
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Cat.#:CTGF-2606HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTGF, Fc-tagged
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Cat.#:CTGF-28023THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTGF
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Cat.#:CTGF-29HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTGF, 182-250aa, His-tagged
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Cat.#:CTGF-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Connective Tissue Growth Factor, His-tagged
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Cat.#:CTGF-852HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human CTGF Protein, DDK-tagged
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Cat.#:Ctgf-2744MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctgf Protein, GST-tagged
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Cat.#:CTGF-4022MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CTGF Protein
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Cat.#:Ctgf-541MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctgf protein, His-tagged
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Cat.#:CTGF-1654RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTGF Protein
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Cat.#:Ctgf-544RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ctgf protein, His-tagged
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Cat.#:CTGF-5847CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTGF
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Cat.#:CTGF-538CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CTGF protein, His & T7-tagged
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Cat.#:CTGF-542STag:His
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep CTGF protein, His-tagged
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Cat.#:CTGF-543PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CTGF protein, His-tagged
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Cat.#:CTGF-7205HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CTGF 293 Cell Lysate
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Involved Pathway

CTGF involved in several pathways and played different roles in them. We selected most pathways CTGF participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid, triacylglycerol, and ketone body metabolism
SLC25A20; MED26; PPARGC1B; AGPAT1; ACAD11; ACSF3; ACOT7; SLC25A1A; MED6; G0S2
Gene Expression
ZIM2; ZNF445; BRF1; ZNF350; DNMT3B; ZNF264; ZNF498; MTERF; CBX3A; HNRNPA0B
Generic Transcription Pathway
COX18; NRBP1; CDK9; ZNF692; NR0B2A; ZNF606; NR4A2B; ZNF697; MED16; ZNF643
Hippo signaling pathway
WNT7B; WNT2B; NF2; INADL; PPP1CB; LLGL1; TEAD3; LATS1; TEAD1; ITGB2L
Metabolism
LMF2; MED26; PDK3; FAAH2A; ARSK; SLC25A15B; LYVE1; SULT1ST6; SULT1ST5; SLC25A2
Metabolism of lipids and lipoproteins
ESRRA; AWAT1; ANKRD1; SLC27A5; YY2; AKR1C2; Agmo; GGTLC1; FABP9; MED21
PPARA activates gene expression
APOA5; SREBF2; MED31; MTF1; MED25; MED22; MED26; CTGF; G0S2; MED29
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED21; MED29; PLIN2; MED19; GRHL1; MED31; MED25; MED22; MED10; MED16

Protein Function

CTGF has several biochemical functions, for example, fibronectin binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTGF itself. We selected most functions CTGF had, and list some proteins which have the same functions with CTGF. You can find most of the proteins on our site.
Function
Related Protein
Function fibronectin binding
Related Protein ITGB1; MYOC; IGFBP5; MFAP2; CTSK; LRRC15; HSD17B12; CCDC80; MMP13; IGFBP5B
Function growth factor activity
Related Protein GMFB; FGF10; FGF7; TGFB1; CSPG5; FGF1B; FGF8B; REG1A; MACC1; BMP6
Function heparin binding
Related Protein ANG; COL13A1; WISP1A; LIPI; FGFBP1; APOH; GM4980; PCSK6; RSPO2; LTF
Function insulin-like growth factor binding
Related Protein HTRA3; ESM1; HTRA1B; IGFBP2B; HTRA4; CYR61; IGFBP3; NOV; HTRA3A; KAZALD1
Function integrin binding
Related Protein CXADR; ECM2; LAMA5; ACTN1; ADAMTS13; EGFL6; CALR; ANGPTL3; ICAM4; ITGB5
Function protein C-terminus binding
Related Protein DGKZ; NCF2; MAP2K1; PRKAA1; BLOC1S2A; MED12; DLG4; SP1; TRIM3; PCGF1
Function protein binding
Related Protein NEK1; CRY2; ZFYVE9; SEMA4D; PHLDA1; SDC1; L3MBTL1; FAM54A; TRIM44; STAT2

Interacting Protein

CTGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTGF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTGF.
FN1; FGFR1OP; FGFR2; FGFR3; LIMS1; q81kk8_bacan; lonB; q81tk4_bacan; rpoB; gnd; nemA; mdtB; rnhA; q9wmx2-pro_0000037548; ITGA5

CTGF Related Articles

Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
Gao, W; Cai, LT; et al. Anti-CTGF Single-Chain Variable Fragment Dimers Inhibit Human Airway Smooth Muscle (ASM) Cell Proliferation by Down-Regulating p-Akt and p-mTOR Levels. PLOS ONE 9:-(2014).