CTGF

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CTGF

Official Full Name connective tissue growth factor
Background The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
Synonyms CTGF; connective tissue growth factor; CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8;
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Sheep
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • Fc
    • GST
    • His
    • Avi
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTGF-2604H Recombinant Human CTGF Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human CTGF-391H Recombinant Human CTGF Protein, His & Avi-tagged, Unconjugated HEK293 His/Avi
    Human CTGF-392H Recombinant Human CTGF protein, His-tagged HEK293 His
    Mouse CTGF-393M Recombinant Mouse CTGF protein, His-tagged HEK293 His
    Human CTGF-16H Recombinant Human CTGF, His-tagged E.coli His
    Human CTGF-2069H Recombinant Human CTGF Protein, GST-tagged Wheat Germ GST
    Human CTGF-2605H Recombinant Human CTGF, His-tagged HEK293 His
    Human CTGF-2606H Recombinant Human CTGF, Fc-tagged Human Cell Fc
    Human CTGF-28023TH Recombinant Human CTGF E.coli N/A
    Human CTGF-29H Recombinant Human CTGF, 182-250aa, His-tagged E.coli His
    Human CTGF-30H Recombinant Human Connective Tissue Growth Factor, His-tagged E.coli His
    Human CTGF-555H Recombinant Human Connective Tissue Growth Factor E.coli N/A
    Human CTGF-7205HCL Recombinant Human CTGF 293 Cell Lysate HEK293 N/A
    Human CTGF-852H Recombinant Human CTGF Protein, DDK-tagged Sf9 Insect Cell DDK
    Mouse Ctgf-2744M Recombinant Mouse Ctgf Protein, GST-tagged E.coli GST
    Mouse CTGF-4022M Recombinant Mouse CTGF Protein Mammalian Cell His
    Mouse Ctgf-541M Recombinant Mouse Ctgf protein, His-tagged E.coli His
    Rat CTGF-1654R Recombinant Rat CTGF Protein Mammalian Cell His
    Rat Ctgf-544R Recombinant Rat Ctgf protein, His-tagged E.coli His
    Chicken CTGF-5847C Recombinant Chicken CTGF Mammalian Cell His
    Cattle CTGF-538C Recombinant Cattle CTGF protein, His & T7-tagged E.coli His/T7
    Sheep CTGF-542S Recombinant Sheep CTGF protein, His-tagged E.coli His
    Pig CTGF-543P Recombinant Pig CTGF protein, His-tagged E.coli His

    CTGF involved in several pathways and played different roles in them. We selected most pathways CTGF participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid, triacylglycerol, and ketone body metabolism ACOT9.1; YAP1; MED10; AGT; ACOT11; CCNC; MTF1; MED31; CDK19; GRHL1
    Gene Expression ZNF471; C7orf59; ZNF785; Txn1; BRF1B; MTERF; TSEN2; KHSRP; ZNF566; MED15
    Generic Transcription Pathway ZNF773; ZNF200; PRDX2; GPR19; ZKSCAN4; ZNF543; ZNF350; ZNF74; PRDM7; ZNF257
    Hippo signaling pathway YWHAB; PPP1CB; WNT5A; TGFBR2; CTNNA2; CCND2; MPP5; AFP; GDF6; PPP2R2A
    Metabolism PDPR; PPARGC1B; GNG13B; ADSS; CA13; ADSL; BSG; ACOT7; ACER1; GCKR
    Metabolism of lipids and lipoproteins CYP2AD2; NFYAL; MED21; CHKA; CLPS; ACOT9.1; ESRRA; CYP4B1; CSNK1G2; PTPMT1
    PPARA activates gene expression GRHL1; MED20; MED15; MED19; MED10; CDK19; MED31; G0S2; CTGF; GLIPR1
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED6; MTF1; MED23; G0S2; MED29; CDK19; MED31; PLIN2; MED7; MED25

    CTGF has several biochemical functions, for example, fibronectin binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTGF itself. We selected most functions CTGF had, and list some proteins which have the same functions with CTGF. You can find most of the proteins on our site.

    Function Related Protein
    fibronectin binding SFRP2; IGFBP3; PLEKHA2; LPA; MYOC; ITGB3; CTSL1; MFAP2; THBS1; FSTL3
    growth factor activity CTGF; GDNF; BMP2; KITLG; WISP3; GDF9; LIF; GDF10; INHBE; VEGFAA
    heparin binding PF4V1; THBS2; ZNF146; FBLN7; LIPH; NAV2; FGF14; FMODA; FSTL1; RSPO4
    insulin-like growth factor binding IGF1RB; IGFBP6A; HTRA4; CTGFA; IGFBP6B; KAZALD2; HTRA1; CTGFB; NOV; IGFBP2A
    integrin binding WISP2; ICAM5; ICAM2; FN1A; TSPAN4; FERMT3; WISP1; THBS1; CD226; COL16A1
    protein C-terminus binding MKI67; MLLT4; ZBTB16; PLEKHB1; PPP1R9B; VIM; PHB; NIPBL; PDZD11; LIG4
    protein binding LARP4B; PITPNM3; MRM1; KIF6; BEND3; UBE2C; BATF; BAI2; RBM4; SYT4

    CTGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTGF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTGF.

    FN1; FGFR1OP; FGFR2; FGFR3; LIMS1; q81kk8_bacan; lonB; q81tk4_bacan; rpoB; gnd; nemA; mdtB; rnhA; q9wmx2-pro_0000037548; ITGA5

    Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
    Gao, W; Cai, LT; et al. Anti-CTGF Single-Chain Variable Fragment Dimers Inhibit Human Airway Smooth Muscle (ASM) Cell Proliferation by Down-Regulating p-Akt and p-mTOR Levels. PLOS ONE 9:-(2014).

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