cdh3
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  • Official Full Name
  • cadherin 3, type 1, P-cadherin (placental)
  • Background
  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
  • Synonyms
  • CDH3; cadherin 3, type 1, P-cadherin (placental); CDHP; HJMD; PCAD
Cat.#:CDH3-2232PTag:His
Source (Host):YeastSpecies:Pig
Product nameRecombinant Pig CDH3 Protein (1-145 aa), His-tagged
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Cat.#:CDH3-0989HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDH3 Protein, GST-Tagged
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Cat.#:Cdh3-1673MTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Mouse Cdh3 protein, Fc-tagged
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Cat.#:CDH3-168HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH3, His-tagged
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Cat.#:CDH3-281HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH3, T7/His-tagged
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Cat.#:CDH3-289HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDH3, MYC/DDK-tagged
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Cat.#:CDH3-488HTag:His/Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human CDH3 protein, His/Fc-tagged
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Cat.#:CDH3-5724HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDH3 protein, His-tagged
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Cat.#:CDH3-3177MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDH3 Protein
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Cat.#:Cdh3-5725MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdh3 protein, His-tagged
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Cat.#:Cdh3-5726MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdh3 protein, His & GST-tagged
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Cat.#:CDH3-7636HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDH3 293 Cell Lysate
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Involved Pathway

Cdh3 involved in several pathways and played different roles in them. We selected most pathways Cdh3 participated on our site, such as Adherens junctions interactions, Cell adhesion molecules (CAMs), Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cdh3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junctions interactions
CDH18; CTNND1; CDH2; PVRL1A; CDH3; CDH6; CDH12A; CTNNB1; CDH9; CDH24
Cell adhesion molecules (CAMs)
JAM2A; CNTNAP2; NLGN4A; SPN; ICAM2; CLDN11A; SELPLG; NFASCA; HLA-DPA1; NCAM1B
Cell junction organization
CDH13; INADL; PLECA; CDH8; JUP; CLDN4; LIMS1; CDH24; TESK1; CLDN16
Cell-Cell communication
SKAP2; CDH7; DSCAML1; COL17A1; CDH17; CDH8; CLDN7; TESK1; PLEC; RSU1
Cell-cell junction organization
CDH13; CTNND1; CDH11; CDH18; PVRL2L; F11R.2; INADL; CDH18A; CDH10A; CDH8

Protein Function

Cdh3 has several biochemical functions, for example, calcium ion binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by Cdh3 itself. We selected most functions Cdh3 had, and list some proteins which have the same functions with Cdh3. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CASQ1B; PCDHGB1; ACTN3B; PCDH2G16; LTBP3; ANXA3; SPARCL1; SLIT3; MBL1; ANXA1B
Function molecular_function
Related Protein PLEKHM3; BRD2A; CCDC172; HEATR7B2; DIA1A; GLIPR1B; TBC1D8; ARGLU1A; SLC41A1; FNDC3C1

Interacting Protein

Cdh3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cdh3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cdh3.
IGF1R; q7ard3_yerpe; y551_bacan; YAP1; AP2M1

Cdh3 Related Articles

Watson, S; Sarris, M; et al. Limbal Dermoid Epithelium Shares Phenotypic Characteristics Common to Both Hair Epidermal and Limbal Epithelial Stem Cells. CURRENT EYE RESEARCH 38:835-842(2013).
Yoshioka, H; Yamamoto, S; et al. In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy. CANCER IMMUNOLOGY IMMUNOTHERAPY 61:1211-1220(2012).