dbh
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  • Official Full Name
  • dopamine beta-hydroxylase (dopamine beta-monooxygenase)
  • Background
  • Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine. DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. DBH is inhibited by disulfiram, tropolone, and, most selectively, by nepicastat.
  • Synonyms
  • DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase; DBM
Cat.#:DBH-2122HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human DBH Protein, His-tagged
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Cat.#:DBH-2366HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DBH Protein, GST-tagged
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Cat.#:DBH-983HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DBH Protein, MYC/DDK-tagged
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Cat.#:DBH-11841HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DBH, GST-tagged
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Cat.#:DBH-210HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human DBH, His tagged
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Cat.#:DBH-26886THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DBH
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Cat.#:DBH-6945HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DBH protein, His & T7-tagged
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Cat.#:DBH-929HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human DBH
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Cat.#:DBH-6041ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DBH
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Cat.#:DBH-869HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human DBH cell lysate
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Involved Pathway

DBH involved in several pathways and played different roles in them. We selected most pathways DBH participated on our site, such as Amine-derived hormones, Biogenic Amine Synthesis, Catecholamine biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amine-derived hormones
CGA; TPH2; DBH; DDC; DIO2
Biogenic Amine Synthesis
DBH; CHAT; COMT; DDC
Catecholamine biosynthesis
DBH; DDC; MOXD2
Metabolic pathways
CYP19A1A; ALPI.1; NT5C3L; GBA2; CYP11C1; NDUFS3; DPM3; BCKDHA; ST6GALNAC3; ATP5J
Metabolism
ABHD14B; AFMID; FAAH2; SLC6A7; DCT; MED21; DIO2; SLC6A12; CERS3B; CYP2K19
Metabolism of amino acids and derivatives
PCBD1; NAGS; AHCY; SLC6A8; SLC25A21; DAO; CTHL; ALDH9A1A.2; BCKDK; SLC25A15B
Monoamine Transport
FBXO32; DBH; UNC13B; TGFB1I1; HRH3; SCAMP2; SYN1; TPH2
Tyrosine metabolism
TPO; TYRP1; MAOB; TYRP1B; PNMT; ALDH3B1; GOT2; AOX3; GOT2A; AOX4

Protein Function

DBH has several biochemical functions, for example, L-ascorbic acid binding, catalytic activity, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBH itself. We selected most functions DBH had, and list some proteins which have the same functions with DBH. You can find most of the proteins on our site.
Function
Related Protein
Function L-ascorbic acid binding
Related Protein OGFOD2; EGLN1B; TMLHE; P4HA1A; EGLN1; PLOD1; LEPRE1; OGFOD3; ALKBH3; P4HA1
Function catalytic activity
Related Protein PPM1NB; MOXD1L; HHIPL1; ALDH1L1; SGSH; ALPI.2; PKMA; HSD3B6; ECHDC3; GLULC
Function copper ion binding
Related Protein PRNP; MT3; S100V2; AOC1; DCT; CCC2; SLC11A2; POLR1B; ATOX1; LOXL5B
Function dopamine beta-monooxygenase activity
Related Protein DBH

Interacting Protein

DBH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBH here. Most of them are supplied by our site. Hope this information will be useful for your research of DBH.
ITSN1

DBH Related Articles

Flak, JN; Myers, B; et al. Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1903-1911(2014).
Lin, LH; Moore, SA; et al. Astrocytes in the Rat Nucleus Tractus Solitarii Are Critical for Cardiovascular Reflex Control. JOURNAL OF NEUROSCIENCE 33:18608-18617(2013).